Protein Alignment Rpn5 and PSMD12

DIOPT Version :9

• Sequence 1: NP_649588.1
• Gene: Rpn5 / 40717
• FlyBaseID: FBgn0028690
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: XP_024306610.1
• Gene: PSMD12 / 5718
• HGNCID: 9557
• Length: 485
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 234/524 - (44%)
• Similarity: 323/524 - (61%)
• Gaps: 86/524 - (16%)

  Fly     9 GRITKMEVDYEPACNEKIPLAKELAKKNPDAFHEAIEMMLQLEKQTRL----------------- 56
            |||.||||||....::::|...:|||:.  ...|.||.:|.||||||.
Human    11 GRIVKMEVDYSATVDQRLPECAKLAKEG--RLQEVIETLLSLEKQTRTVSSLQGKAQLPLISLNI 73

  Fly    57 ------------GADMVSCSRVLVAICQICFDASNWNALNEYVSLLVRRRSQLKQAVVKMIQECV 109
                        .:||||.||:|||:.::|::|..|:.|||.:.||.:|||||||||.||:|:|.
Human    74 LPLTFNIFLPLQASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCC 138

  Fly   110 TYVDKTPDKETKLKLIDTLRSVTEGKIYVEIERARLTKILADIKEADGDVAGAATVMEELQVETY 174
            |||::..|...||:||||||.|||||||||||||||||.||.|||.:|||..||::::|||||||
Human   139 TYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETY 203

  Fly   175 GSMDKREKVELILEQMRLCLLKEDYVSTQIIAKKISIKFFDDPAQHDLKLKFYYLMIQLNR-DTS 238
            |||:|:|:||.|||||||||..:||:.||||:|||:.|||.:.....||||:|.|||||:: :.|
Human   204 GSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGS 268

  Fly   239 FLNTSRHYQAIAEPPRKKTGLTPVDSAASTDEQKKKDDDKKKKEEDDKDKKPEVATEAEVEIELT 303
            :|:..:||:||.:.|                                       ..:||.|
Human   269 YLSICKHYRAIYDTP---------------------------------------CIQAESE---- 290

  Fly   304 EEQKKELTEKLVCAVLYCVLAPFDNEQSDMMAHLSKNKKLEEVPAYKEILRLFMSKELINFDTFN 368
                 :..:.|...|||.:||||||||||::..:|.:|||||:|.||::|:||.:.||:.:.|..
Human   291 -----KWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLV 350

  Fly   369 ADFGLVLAENEMFK------DSTKHGKKCITELKDRLIEHNIRIIAMYYSRLHLARMSELLNLPT 427
            .|:|:.|.:..:..      .||:.|:|...:||:|::||||||:|.||:|:.:.||::||:|..
Human   351 EDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSV 415

  Fly   428 SRCEEYLSKLANTDTIRVKIDRPAGIIYFTQKKSASDILNNWATDVNQLMSLVNKTCHLINKEEC 492
            ...|.:||.|....||..|:||.||||.|.:.|..:::||:|:..:|.||||||||.|||.|||.
Human   416 DESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEM 480

  Fly   493 VYSV 496
            ::::
Human   481 IHNL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn5	NP_649588.1	RPN5	13..496	CDD:227403	231/518 (45%)
PSMD12	XP_024306610.1	RPN5	14..485	CDD:227403	231/521 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146036
Domainoid	1	1.000	299	1.000	Domainoid score	I1451
eggNOG	1	0.900	-	-		E1_COG5071
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2109
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1751
Isobase	1	0.950	-	0	Normalized mean entropy	S656
OMA	1	1.010	-	-		QHG54023
OrthoDB	1	1.010	-	-		D246241at33208
OrthoFinder	1	1.000	-	-		FOG0003700
OrthoInspector	1	1.000	-	-		oto89720
orthoMCL	1	0.900	-	-		OOG6_102014
Panther	1	1.100	-	-	LDO	PTHR10855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2265
SonicParanoid	1	1.000	-	-		X2567
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750