DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hat1 and hat1

DIOPT Version :9

Sequence 1:	NP_649587.1	Gene:	Hat1 / 40716	FlyBaseID:	FBgn0037376	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001004572.1	Gene:	hat1 / 447833	ZFINID:	ZDB-GENE-040912-99	Length:	408	Species:	Danio rerio

Alignment Length:	401	Identity:	165/401 - (41%)
Similarity:	250/401 - (62%)	Gaps:	7/401 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EKYQDFVIDALEVVDFKLIRDKADINNDALTFHPAMAHQIFGETETIFGYQDLHVRVMYTAGPLH 69
            :|..::..|..|.:..||:|...||::::.||||..:||:||:.|..|||:.|.:::..:||.|:
Zfish     9 KKLAEYKCDTNEAICLKLVRFPEDIDDESTTFHPEFSHQLFGDDEVAFGYKGLQIQLYQSAGNLN 73

  Fly    70 IYLGVDYGKRVNEISGGEIKADDVVSTIAQSLPDGCYFINLDEFLKTLDKADKFQPFGEKISEYR 134
            ....|.|..||.: ....::.|||...|.:.:|.| :..|.|:|:..|:|...|:|||.....|:
Zfish    74 TLFKVKYTARVTD-KFDCVEPDDVEGKIREIIPAG-FCCNTDDFISVLEKEANFKPFGSLQHTYK 136

  Fly   135 RVSDDGSERL-FEIYQCEYKSSSFLKFFARLQTFILWFVDAASYIDTDDPQWCYFLSYEKYKNND 198
            ..:.:..|.| ::|::.:.....|.::..|||||::||::.||:||.||.:|.:||.:||| |.|
Zfish   137 VHNVEAGEDLTYQIHKVDISCPGFREYHERLQTFLMWFIETASFIDVDDDRWDFFLVFEKY-NKD 200

  Fly   199 GQWQYATAGYTTVYEYYAYPQNKRPRISQMLILPPFQKLGLATQLVESIYRFYQSQKNVVDITVE 263
            |:..|||.||.|||.||.||...|||:||||||||||..|...||:|:::|:|.:...|.|||.|
Zfish   201 GETLYATVGYMTVYNYYVYPDKTRPRVSQMLILPPFQGEGHGAQLLETVHRYYCTSPKVQDITAE 265

  Fly   264 DPSEDFQRLRNFVDARSCMKLKSFAPGEIVKGFNKEMVREAREALKLNPLQVRKVYELLRLFYTN 328
            ||||::.:||:||..:.|:.|.|||..::.:||::||..||||.||:|....|:|||:|||..|:
Zfish   266 DPSENYVKLRDFVLVKLCLTLPSFASEKLSQGFSEEMASEAREKLKINKKHARRVYEILRLRNTD 330

  Fly   329 VKDEKEYRPYRLEVKKRLNAVYYKQLKDLKKMERFKMDTEMLR--ARLPTVQQRMEQLHEEYRVV 391
            :.|||:.|.:||||||||...|.|..::|.||.:.....|:..  :::.|..|. |:|.:.|:.|
Zfish   331 MNDEKKAREFRLEVKKRLFGPYRKNQRELTKMRKCLRPEELASHISQMDTTLQH-EELEKSYQDV 394

  Fly   392 EQEYQSTIAKL 402
            ..||:..:.:|
Zfish   395 VAEYRRVLERL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hat1	NP_649587.1	Hat1_N	10..173	CDD:287379	54/163 (33%)
Hat1	NP_649587.1	Med21	<368..403	CDD:288119	10/37 (27%)
hat1	NP_001004572.1	Hat1_N	14..176	CDD:287379	54/163 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592463
Domainoid	1	1.000	211	1.000	Domainoid score	I2743
eggNOG	1	0.900	-	-		E1_KOG2696
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2701
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2558
OMA	1	1.010	-	-		QHG55168
OrthoDB	1	1.010	-	-		D500261at33208
OrthoFinder	1	1.000	-	-		FOG0004691
OrthoInspector	1	1.000	-	-		oto39713
orthoMCL	1	0.900	-	-		OOG6_102175
Panther	1	1.100	-	-	LDO	PTHR12046
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R551
SonicParanoid	1	1.000	-	-		X3295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800