DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hat1 and Hat1

DIOPT Version :9

Sequence 1:	NP_649587.1	Gene:	Hat1 / 40716	FlyBaseID:	FBgn0037376	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_017447113.1	Gene:	Hat1 / 296501	RGDID:	1305716	Length:	436	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	159/403 - (39%)
Similarity:	248/403 - (61%)	Gaps:	11/403 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EKYQDFVIDALEVVDFKLIRDKADINNDALTFHPAMAHQIFGETETIFGYQDLHVRVMYTAGPLH 69
            :|..::..:....::.||:|...|:.||..||.|...||:||:.||.|||:.|.:.:.|.||.|.
  Rat    37 KKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLS 101

  Fly    70 IYLGVDYGKRVNEISGGEIKADDVVSTIAQSLPDGCYFINLDEFLKTLDKADKFQPFGEKISEYR 134
            ....|:|..:|:| :...::||||...|.|.:|.| :..|.::||..|:|...|:|||..:..|.
  Rat   102 TMFRVEYASKVDE-NFDCVEADDVEGKIRQIIPPG-FCTNTNDFLSLLEKEADFKPFGTLLHTYS 164

  Fly   135 RVSDDGSERL-FEIYQCEYKSSSFLKFFARLQTFILWFVDAASYIDTDDPQWCYFLSYEKYKNND 198
            ..|..|.|.. |:||:.:.....|.::..|||||::||::.||:||.||.:|.|||.:||| |.|
  Rat   165 VPSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKY-NKD 228

  Fly   199 GQWQYATAGYTTVYEYYAYPQNKRPRISQMLILPPFQKLGLATQLVESIYRFYQSQKNVVDITVE 263
            |...:||.||.|||.||.||...|||:||||||.|||..|...||:|:::|:|.:..:|:|||.|
  Rat   229 GATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYIASSSVLDITAE 293

  Fly   264 DPSEDFQRLRNFVDARSCMKLKSFAPGEIVKGFNKEMVREAREALKLNPLQVRKVYELLRLFYTN 328
            |||:.:.:||:||..:.|..|..|:...:::|||::|..:|::..|:|....|:|||:|||..|:
  Rat   294 DPSKSYVKLRDFVLVKLCQDLPCFSRERLLQGFNEDMAIQAQQKFKINKQHARRVYEILRLLVTD 358

  Fly   329 VKDEKEYRPYRLEVKKRLNAVYYKQLKDLKKMERF----KMDTEMLRARLPTVQQRMEQLHEEYR 389
            :.|.::.|.|||::|:||.:.|.|:..||.||.:.    ::..:|.:..: :||.  |||.|:::
  Rat   359 MSDAEQCRSYRLDIKRRLISPYKKKQTDLAKMRKCLRPEELTNQMNQIEI-SVQH--EQLEEQFQ 420

  Fly   390 VVEQEYQSTIAKL 402
            .:.::|:..|.:|
  Rat   421 ELVEDYRRVIERL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hat1	NP_649587.1	Hat1_N	10..173	CDD:287379	59/163 (36%)
Hat1	NP_649587.1	Med21	<368..403	CDD:288119	10/35 (29%)
Hat1	XP_017447113.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350737
Domainoid	1	1.000	197	1.000	Domainoid score	I3023
eggNOG	1	0.900	-	-		E1_KOG2696
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2701
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2549
OMA	1	1.010	-	-		QHG55168
OrthoDB	1	1.010	-	-		D500261at33208
OrthoFinder	1	1.000	-	-		FOG0004691
OrthoInspector	1	1.000	-	-		oto95970
orthoMCL	1	0.900	-	-		OOG6_102175
Panther	1	1.100	-	-	LDO	PTHR12046
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810