DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hat1 and hat1

DIOPT Version :9

Sequence 1:	NP_649587.1	Gene:	Hat1 / 40716	FlyBaseID:	FBgn0037376	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001120116.1	Gene:	hat1 / 100145138	XenbaseID:	XB-GENE-952148	Length:	426	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	163/406 - (40%)
Similarity:	254/406 - (62%)	Gaps:	11/406 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AQIEKYQDFVIDALEVVDFKLIRDKADINNDALTFHPAMAHQIFGETETIFGYQDLHVRVMYTAG 66
            |..:|..::..|..|.:..||:|...||.::::||:|..:|||||:.|..|||:.|.:.:.|:||
Frog    24 AMEKKLAEYKCDTNEAIKLKLVRFPEDIEDESMTFNPEYSHQIFGDEEVAFGYKGLKILLYYSAG 88

  Fly    67 PLHIYLGVDYGKRVNEISGGEIKADDVVSTIAQSLPDGCYFINLDEFLKTLDKADKFQPFGEKIS 131
            .|.....|:|..:|:: ....::.|||.:.|.:.:|.| :....|:|:..|:|...|:|.|..:.
Frog    89 NLSNMFRVEYSSKVDD-KFDLVQPDDVENKIRELIPSG-FCCGSDDFISLLEKEVNFKPMGTVVH 151

  Fly   132 EYRRVSDDGSERL-FEIYQCEYKSSSFLKFFARLQTFILWFVDAASYIDTDDPQWCYFLSYEKYK 195
            .|...:::..|.: ::||:.:.....|.::..|||||::||::.|||||.||.:|.|||.:|||
Frog   152 TYTVHNEEAGEDITYQIYKADMTCPGFREYHERLQTFLMWFIETASYIDVDDEKWDYFLVFEKY- 215

  Fly   196 NNDGQWQYATAGYTTVYEYYAYPQNKRPRISQMLILPPFQKLGLATQLVESIYRFYQSQKNVVDI 260
            |.||...|||.||.|||.||.||...|||:||||:|||||..|...||:|:::|:|.|..|::||
Frog   216 NKDGATLYATVGYMTVYNYYVYPDKTRPRVSQMLVLPPFQGEGHGAQLLETVHRYYVSASNILDI 280

  Fly   261 TVEDPSEDFQRLRNFVDARSCMKLKSFAPGEIVKGFNKEMVREAREALKLNPLQVRKVYELLRLF 325
            |.|||||:|.|||:||..:.|..|..|:..:::.||::|||.||:|.||:|....|:|||:|||.
Frog   281 TAEDPSENFVRLRDFVLVKLCQNLPCFSLEKLLCGFSQEMVTEAQEKLKINKKHARRVYEILRLR 345

  Fly   326 YTNVKDEKEYRPYRLEVKKRLNAVYYKQLKDLKKMERF----KMDTEMLRARLPTVQQRMEQLHE 386
            .|::.|.::.:.|||:|||||...|.|..:::.||::.    ::..:|.:..|.|   :.|||.|
Frog   346 ATDMSDSEKAKAYRLDVKKRLVGPYKKNQREMAKMKQCLRPEELTNQMNQIDLNT---QHEQLEE 407

  Fly   387 EYRVVEQEYQSTIAKL 402
            .|:.:.:||:..:.:|
Frog   408 SYQQLVEEYRRIVERL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hat1	NP_649587.1	Hat1_N	10..173	CDD:287379	52/163 (32%)
Hat1	NP_649587.1	Med21	<368..403	CDD:288119	11/35 (31%)
hat1	NP_001120116.1	Hat1_N	32..194	CDD:371026	52/163 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2736
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2701
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2529
OMA	1	1.010	-	-		QHG55168
OrthoDB	1	1.010	-	-		D500261at33208
OrthoFinder	1	1.000	-	-		FOG0004691
OrthoInspector	1	1.000	-	-		oto102712
Panther	1	1.100	-	-	LDO	PTHR12046
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R551
SonicParanoid	1	1.000	-	-		X3295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110