Protein Alignment kat-60L1 and SAP1

DIOPT Version :10

• Sequence 1: NP_001163523.1
• Gene: kat-60L1 / 40715
• FlyBaseID: FBgn0037375
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_010966.1
• Gene: SAP1 / 856771
• SGDID: S000000849
• Length: 897
• Species: Saccharomyces cerevisiae
• Alignment Length: 650
• Identity: 203/650 - (31%)
• Similarity: 305/650 - (46%)
• Gaps: 174/650 - (26%)

  Fly   136 ITATSRPSRNASLKKSSEGGHSSTAERHRPVNNLGSNAPGGLGIGGSVPLRSKQRLPTQVSAAEV 200
            ::.||..|.|.|:..|                   .|.||.          ..|.|||...|...
Yeast   306 LSVTSSTSSNKSVSSS-------------------ENVPGS----------CIQSLPTTAPALPS 341

  Fly   201 APQP------RASQTAQMPFPSQQQDNRWVSSLRRRDPELQ-----------------PTL---- 238
            .|.|      |||.|..:. |...:.:..:.|.:.|:|::.                 |||
Yeast   342 LPPPPLLNVDRASSTGALK-PHSLETSTTMDSSKIRNPQISKLMKNNHVPYLKGTKSTPTLITKS 405

  Fly   239 -PSI--NSNANSSSLSQSHHGSAGNVGLAGAGAPTPAASMGTMRLGRPARASAMTAALRKSRSVE 300
             |:.  .|.:|:..:.:|:           |.:||.:.::....:.:|     .|||:...|.
Yeast   406 TPTFITRSKSNTKPIIKSN-----------ASSPTSSLTVPNSVIQKP-----KTAAMAAKRV-- 452

  Fly   301 RLRARKLSTNTQLN--------LKHKPVK-KNSLDENSNSDDQDATTSLEDNSH--AQSLATSHN 354
             |.::|:::|..||        ||.|..| .||..:.::|......::.:..||  :|:...|.|
Yeast   453 -LNSKKVASNPALNTTKKSHPILKSKTAKVPNSSSKKTSSHPSRPVSNSKPYSHGASQNKKPSKN 516

  Fly   355 TPKCSPKTKAK----------------------HFSPLG----------------YEVHLVDTLE 381
            ......||..|                      |.:.|.                .|..::|:|:
Yeast   517 QTTSMSKTNRKIPAQKKIGSPKIEDVGTEDATEHATSLNEQREEPEIDKKVLREILEDEIIDSLQ 581

  Fly   382 -----------KDILQRHPCIKWTDVAGLNEAKTILQEAVVLPVIMPEFFKGIRRPWRGVLMVGP 435
                       .:|:.....:.|.|:|||..||..|:||||.|.:.|:.|:|:|.|.||:|:.||
Yeast   582 GVDRQAAKQIFAEIVVHGDEVHWDDIAGLESAKYSLKEAVVYPFLRPDLFRGLREPVRGMLLFGP 646

  Fly   436 PGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDALCA 500
            |||||||||:|||||..:|||::|:|:|||||.||||||||.||.:|:..:||.||:||||::..
Yeast   647 PGTGKTMLARAVATESHSTFFSISASSLTSKYLGESEKLVRALFAIAKKLSPSIIFVDEIDSIMG 711

  Fly   501 SRGSDSEHEASRRFKAELLIQMDGLNASM----------------QEEKVIMVLAATNHPWDIDE 549
            ||.:::|:|:|||.|.|.|:|...|:::.                :::..::||||||.||.|||
Yeast   712 SRNNENENESSRRIKNEFLVQWSSLSSAAAGSNKSNTNNSDTNGDEDDTRVLVLAATNLPWSIDE 776

  Fly   550 AFRRRFEKRIYIPLPNEGTRSALLKLCL---KDVCLSPSLNTGIIGDEL----QGYSGSDISNVC 607
            |.||||.:|.|||||.:.||....|..|   |........      |||    :|||||||:::.
Yeast   777 AARRRFVRRQYIPLPEDQTRHVQFKKLLSHQKHTLTESDF------DELVKITEGYSGSDITSLA 835

  Fly   608 RDASMMAMRRLISGRTPDQIKQIRREEVDQPITLQDFQDARLRTKKSVSADDVARFEKWMEEYGS 672
            :||:|..:|.|     .|::.:..||.: :||.|.||:::.:..|.|||.|.:.::|||..::||
Yeast   836 KDAAMGPLRDL-----GDKLLETEREMI-RPIGLVDFKNSLVYIKPSVSQDGLVKYEKWASQFGS 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kat-60L1	NP_001163523.1	P-loop containing Nucleoside Triphosphate Hydrolases	395..561	CDD:476819	94/181 (52%)
		AAA_lid_3	591..629	CDD:465537	16/41 (39%)
		Vps4_C	<638..671	CDD:462762	13/32 (41%)
SAP1	NP_010966.1	Herpes_BLLF1	<353..543	CDD:282904	42/209 (20%)
		McrB	<539..>659	CDD:441011	39/119 (33%)
		RecA-like_VPS4-like	607..788	CDD:410917	93/180 (52%)
		AAA_lid_3	815..850	CDD:465537	16/45 (36%)
		Vps4_C	<847..893	CDD:462762	16/46 (35%)