Protein Alignment kat-60L1 and KATNAL2

DIOPT Version :10

• Sequence 1: NP_001163523.1
• Gene: kat-60L1 / 40715
• FlyBaseID: FBgn0037375
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001340828.1
• Gene: KATNAL2 / 83473
• HGNCID: 25387
• Length: 564
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 183/501 - (36%)
• Similarity: 259/501 - (51%)
• Gaps: 88/501 - (17%)

  Fly   205 RASQTAQMPFPSQQQDNRWVSSLRRRDPELQPTLPSINSNANSSSLSQSHHGSAGNVGLAGAGAP 269
            ::|.||:...|.:.:     ...||...:....||.||.....|..      :||..|
Human   118 KSSDTAENNLPQRSR-----GKTRRMMNDSCQNLPKINQQRPRSKT------TAGKTG------- 164

  Fly   270 TPAASMGTMRLGRPARASAMTAALRKSRSVERL--RARKLSTNTQLNLKHKPVKKNSLDENSNS- 331
                               .|.:|.|....:.:  ..|..|.|..|::..  ::|:|.:||::.
Human   165 -------------------DTKSLNKEHPNQEVVDNTRLESANFGLHISR--IRKDSGEENAHPR 208

  Fly   332 -----DDQDATTSLEDNSHAQSLATSH---NTPKCSPKTKAKHFSPLGYEV-------HLVDTLE 381
                 |.|...|.      |...|||.   ||...:|....:...||...:       .|...:.
Human   209 RGQIIDFQGLLTD------AIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVS 267

  Fly   382 KDILQRHPCIKWTDVAGLNEAKTILQEAVVLPVIMPEFFKGIRRPWRGVLMVGPPGTGKTMLAKA 446
            :||...:|.|||.|:.||:.||.:::||||.|:..|:.|.||..||:|:|:.||||||||:||||
Human   268 RDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKA 332

  Fly   447 VATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDALCASRG--SDSEHE 509
            |||||.|||||:|:||:.||:||:||||||:|||:||::||||||:||::::.:.||  |..|||
Human   333 VATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHE 397

  Fly   510 ASRRFKAELLIQMDGLNASMQEEKVIMVLAATNHPWDIDEAFRRRFEKRIYIPLPNEGTRSALLK 574
            .|.|.|.|||:|||||..|   |.::.||||:|.||::|.|..||.||||.:.||:...|.|::.
Human   398 GSLRMKTELLVQMDGLARS---EDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIY 459

  Fly   575 LCLKDVC------LSPSLNTGIIGDELQGYSGSDISNVCRDASMMAMRRLISGRTPDQIKQIRRE 633
            ..|..|.      |...|...::..|.:|||||||..|||:|:|..:|::.     |.::..:.|
Human   460 HWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIF-----DALENHQSE 519

  Fly   634 EVDQP------ITLQDFQDARLRTKKSVSADDVA-RFEKWMEEYGS 672
            ..|.|      :|..||.|....||.  ||.::| |:..|..|:.|
Human   520 SSDLPRIQLDIVTTADFLDVLTHTKP--SAKNLAQRYSDWQREFES 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kat-60L1	NP_001163523.1	P-loop containing Nucleoside Triphosphate Hydrolases	395..561	CDD:476819	100/167 (60%)
		AAA_lid_3	591..629	CDD:465537	15/37 (41%)
		Vps4_C	<638..671	CDD:462762	13/39 (33%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913
		RPT1	212..548	CDD:440835	152/351 (43%)
		RecA-like_VPS4-like	282..446	CDD:410917	99/166 (60%)