Protein Alignment kat-60L1 and FIGN

DIOPT Version :10

• Sequence 1: NP_001163523.1
• Gene: kat-60L1 / 40715
• FlyBaseID: FBgn0037375
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_047300819.1
• Gene: FIGN / 55137
• HGNCID: 13285
• Length: 785
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 166/620 - (26%)
• Similarity: 285/620 - (45%)
• Gaps: 83/620 - (13%)

  Fly    87 FVPTYRHTPYHSLWDLHQCSSTPPTSL--SHMARMMDSLILDSLSPFGFTKITATSRPSRNASLK 149
            :.|.|..:..||.:     ||.|..:|  .|.:.:..|.:|....|   ........|..|.:..
Human   211 YAPGYNGSYLHSTY-----SSQPAPALPSPHPSPLHSSGLLQPPPP---PPPPPALVPGYNGTSN 267

  Fly   150 KSSEGGHSSTAERHRPVNNLGSN-APGGLGIGGSVPLRSKQRLPTQVSAAEVAPQPRASQTAQMP 213
            .||   :|..:..:.|...:||. :|||      .|......||:.:.    ||.|....|
Human   268 LSS---YSYPSASYPPQTAVGSGYSPGG------APPPPSAYLPSGIP----APTPLPPTT---- 315

  Fly   214 FPSQQQDNRWVSSLRRRDPELQPTLPSINSNANSSSLSQSHHGSAG------NVGLAGAG----- 267
                      |.....:...|.|..||..:|:::|||.:.....||      :.|....|
Human   316 ----------VPGYTYQGHGLTPIAPSALTNSSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRST 370

  Fly   268 -AP---TPAASMGTMRLGRPARASAMTAAL-----RKSRSVERLRARKLSTNTQLNLKHKPVKKN 323
             :|   .|..|:.....|.....||.|::|     ::..|.|:.|.....::..|........||
Human   371 QSPMYRMPDNSISNTNRGNGFDRSAETSSLAFKPTKQLMSSEQQRKFSSQSSRALTPPSYSTAKN 435

  Fly   324 SLDENSNSDDQDATT---SLEDNSHAQSLATSHNTPKCSPKTKAKHF---SPLGYEVHLVDTLEK 382
            ||...|:......|:   |...:.|.|.|:.....|.....|.:.|.   .....:.||:|.:..
Human   436 SLGSRSSESFGKYTSPVMSEHGDEHRQLLSHPMQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTN 500

  Fly   383 DILQRHPCIKWTDVAGLNEAKTILQEAVVLPVIMPEFFKGIRRPWRGVLMVGPPGTGKTMLAKAV 447
            :|:.:.|.:.|.|:|||:..|.:::|.|:.||:..:.|.|:....|.:|:.||.|||||:|.:.:
Human   501 EIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCI 565

  Fly   448 ATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDALCASRGSDSEHEASR 512
            |::.|.|||.::.|.|.:|:.||:||::...|.:||...||.||:.:||.|.:|:.:: ||....
Human   566 ASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNE-EHSPVS 629

  Fly   513 RFKAELLIQMDGLNASMQEEKVIMVLAATNHPWDIDEAFRRRFEKRIYIPLPNEGTRSALLKLCL 577
            |.:.|.|:|:|.:..|.:::  |:|:.||:.|.:|||:.||.|.||:.||||:...|..::...|
Human   630 RMRTEFLMQLDTVLTSAEDQ--IVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLL 692

  Fly   578 K--DVCLSPSLNTGIIGDELQGYSGSDISNVCRDASMMAMRRL----ISGRTPDQIKQIRREEVD 636
            .  :.||:.. ...::....:|:||.|::::|::|.:..:..:    :|...|.|::
Human   693 SQHNYCLNDK-EFALLVQRTEGFSGLDVAHLCQEAVVGPLHAMPATDLSAIMPSQLR-------- 748

  Fly   637 QPITLQDFQDARLRTKKSVSADDVARFEKWMEEYG 671
             |:|.|||::|..:.:.|:|..::..:.:|.:.:|
Human   749 -PVTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kat-60L1	NP_001163523.1	P-loop containing Nucleoside Triphosphate Hydrolases	395..561	CDD:476819	65/165 (39%)
		AAA_lid_3	591..629	CDD:465537	9/41 (22%)
		Vps4_C	<638..671	CDD:462762	9/32 (28%)
FIGN	XP_047300819.1	RecA-like_fidgetin	513..676	CDD:410931	65/165 (39%)
		AAA_lid_3	701..>732	CDD:465537	6/31 (19%)
		Vps4_C	<749..782	CDD:462762	9/32 (28%)