Protein Alignment kat-60L1 and FIGNL2

DIOPT Version :10

• Sequence 1: NP_001163523.1
• Gene: kat-60L1 / 40715
• FlyBaseID: FBgn0037375
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_016874787.1
• Gene: FIGNL2 / 401720
• HGNCID: 13287
• Length: 767
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 169/773 - (21%)
• Similarity: 267/773 - (34%)
• Gaps: 214/773 - (27%)

  Fly    50 RQRSLTSSNPVLGRSNALATRPQS-------------PPNVQVEYEVAVPFVP--------TYRH 93
            |||....::|...|.....|.|:|             ||    ....|:|.||        ....
Human    57 RQRGAPDADPRGDRHWKDLTSPRSQGHPKWTEDSPWRPP----LSTCALPAVPITECTALLKMHW 117

  Fly    94 TPYH----SLW-DLH-QCSSTPPTSLSHMARMMDSLILDSLSPFG------------FTKITATS 140
            ||.|    :.| :.| ..|||.|:....:          .|.|.|            .:.:||::
Human   118 TPEHAQPLNQWPEQHLDVSSTTPSPAHKL----------ELPPGGRQRCHYAWAHDDISALTASN 172

  Fly   141 RPSRNAS---------LKKSSEGGHSST----------------------AERHRPVNNLGSNAP 174
            ...|.|.         .::.:.||:|..                      |..|..:....|...
Human   173 LLKRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKSGGG 237

  Fly   175 GGLG-IGGSVPLRSKQRLPTQVSAAEVAPQPRA------------------SQT-AQMPFPSQQQ 219
            ||.| :|||..|..  .||..:.|......|.|                  :|| |.:|.|..
Human   238 GGSGALGGSPVLAG--NLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALPPPPP-- 298

  Fly   220 DNRWVSSLRRRDPE--LQPTLPSINSNANSSSLSQSHHGSAGNVGLA----------------GA 266
                 ::|.:..|.  ..|:.|..|..|.         |.|...|..                |.
Human   299 -----AALLQPPPPPGYGPSAPLYNYPAG---------GYAAQPGYGALPPPPGPPPAPYLTPGL 349

  Fly   267 GAPTP-AASMGTMRLGRPARASAMTAALRKSRSVERLRARKLSTNTQLNLKHKPVKKNSLDENSN 330
            .|||| .|.......|.|..|....:.|    |::|..|.:..........::|.|....|
Human   350 PAPTPLPAPAPPTAYGFPTAAPGAESGL----SLKRKAADEGPEGRYRKYAYEPAKAPVAD---- 406

  Fly   331 SDDQDATTSLEDNSHAQSLATSHNTPKCSPKTKAKH----------------------------- 366
                .|:....||...:........|..:.:...|:
Human   407 ----GASYPAADNGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAP 467

  Fly   367 -----------FSPLGYEVHLVDTLEKDILQRHPCIKWTDVAGLNEAKTILQEAVVLPVIMPEFF 420
                       .:|.|.:...::.:...::...|.::|.||||....|..|:|.:|.|::.|..:
Human   468 APRGGFAVPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAY 532

  Fly   421 KGIRRPWRGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFY 485
            .|..||.|.||:.||.|.||.:|.:.:||:.|.|...:..:||.:....|..:|::..|..||..
Human   533 PGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCR 597

  Fly   486 APSTIFIDEIDALCASRGSDSEHEASRRFKAELLIQMDGLNASMQEEKVIMVLAATNHPWDIDEA 550
            .||.:.|.|::||..:|  |....|....:..||..:||...:..:.  ::|:..|:.|..:|||
Human   598 PPSVLLISELEALLPAR--DDGAAAGGALQVPLLACLDGGCGAGADG--VLVVGTTSRPAALDEA 658

  Fly   551 FRRRFEKRIYIPLPNEGTRSALLKLCL-KDVCLSPSLNTGIIGDELQGYSGSDISNVCRDASMMA 614
            .||||..|.|:.||:...|..:|:..| :..|.........:....||:||.::..:|:.|:..|
Human   659 TRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGA 723

  Fly   615 MRRLISGRTPDQIKQIRREEVDQPITLQDFQDARLRTKKSVSADDVARFEKWMEEYGS 672
            .   :.|             :.:|::.:|.:.|..:.....||.::..|.:|.:.|||
Human   724 G---LPG-------------LQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGS 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kat-60L1	NP_001163523.1	P-loop containing Nucleoside Triphosphate Hydrolases	395..561	CDD:476819	57/165 (35%)
		AAA_lid_3	591..629	CDD:465537	8/37 (22%)
		Vps4_C	<638..671	CDD:462762	7/32 (22%)
FIGNL2	XP_016874787.1	RecA-like_fidgetin	507..669	CDD:410931	57/165 (35%)
		HflB	<643..>720	CDD:440233	23/76 (30%)