DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2082 and NDRG2

DIOPT Version :9

Sequence 1:	NP_001163513.1	Gene:	CG2082 / 40713	FlyBaseID:	FBgn0027608	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_001341487.1	Gene:	NDRG2 / 57447	HGNCID:	14460	Length:	389	Species:	Homo sapiens

Alignment Length:	372	Identity:	103/372 - (27%)
Similarity:	171/372 - (45%)	Gaps:	50/372 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PGTPKHGAGSSSAAA--APEKISKYNISTEKCGDLTVIVQGDLSQQEKRAVFITVHDLGCNHNS- 65
            ||.....|..:..||  ..::...:::.| ..|.:|..|.|  :.:.||...:|.||:|.|:.|
Human    17 PGQTPEAAKEAELAARILLDQGQTHSVET-PYGSVTFTVYG--TPKPKRPAILTYHDVGLNYKSC 78

  Fly    66 FQEFVSSPCMTEIKERSCFIHVDVPGHADNAEALADGFPFPSLQSLGEDLVTVLDYLHVKYVIGL 130
            ||.......|.||.:....:|||.||..:.|.....|:.:|||..|.:.:..||.||:...:||:
Human    79 FQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGV 143

  Fly   131 GEGAGANVLARFGLAHPSRVLGLILINATGSAASVVQSFKNKFISW---KSDEVAQSAESFLMYH 192
            |.||||.:|||:.|.||..|.||:|||...:|..        ::.|   |...:..|....::.|
Human   144 GVGAGAYILARYALNHPDTVEGLVLINIDPNAKG--------WMDWAAHKLTGLTSSIPEMILGH 200

  Fly   193 KFGHVMEQIVGENPDKEKIVAEYQKRLHRSLNSKNIGLYVKAFMNRKDLTLK-----GCKVDVIL 252
            .|.  .|::.|.:    :::.:|:..:..:.|..||.||..::.||:||..:     ..:..|:|
Human   201 LFS--QEELSGNS----ELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVML 259

  Fly   253 ITGMLSPYASMV------------------EKLHRDVEKERVTILKI-ERAGDVLADAPGKVAQS 298
            :.|..:|:...|                  .:.:..::..:.:.||: :..|......|||:.::
Human   260 VVGDQAPHEDAVGDQLWGTKNLIPASCLLQVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEA 324

  Fly   299 ILLFCKGQGLLTSVVMPGVDRGRAFSTASSGSLEGANGSRRLSRGIS 345
            ...|.:|.|.:.|..|..:.|.|..|..|:.|::| |.||  ||.:|
Human   325 FKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDG-NRSR--SRTLS 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2082	NP_001163513.1	Abhydrolase	26..310	CDD:419691	84/311 (27%)
NDRG2	NP_001341487.1	Ndr	40..336	CDD:251726	84/312 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2931
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5286
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.840