DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sec8 and EXOC4

DIOPT Version :9

Sequence 1:NP_730996.2 Gene:Sec8 / 40712 FlyBaseID:FBgn0266672 Length:985 Species:Drosophila melanogaster
Sequence 2:NP_068579.3 Gene:EXOC4 / 60412 HGNCID:30389 Length:974 Species:Homo sapiens


Alignment Length:1013 Identity:350/1013 - (34%)
Similarity:558/1013 - (55%) Gaps:112/1013 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 GVKY------GKDESAGCGFLVNVIKSLGFSETTEERQKEKQKIEAEFKRSDLRLNELVSRHDQQ 70
            |.||      .||.|   |.|::||::|..|:..|:|:.||.::|..:::.|..|:||:.:|..:
Human     7 GGKYRSTVSKSKDPS---GLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTE 68

  Fly    71 LTQVLPLFSQVSSEVTASRERIHAVKENLGVCKRLLQCRRDELRKMWMDAVQHKYVLEMLEQIQE 135
            ||..:..:..::..:|.||.:|..|||||..||.||.|:||||||:|::.::||:||.:|::|:.
Human    69 LTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIEN 133

  Fly   136 LRKVPQRVVGYTAKRQYLHASKALTDALTTLNGPLQAVEGLSDLRTDLQTRRQQLYQRLHEELVT 200
            :::|||::....|.:.||.|:..|..|:.:|.|||..||||||||.:|.:::..|:..|.:||..
Human   134 IKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHR 198

  Fly   201 QVYTNSANEALSSFQRTNSSRLNSSFTRGIGA-----------RRSTDRIEANARVRKALAEMAQ 254
            .:|..|.:..:   ||.......||..:....           |:..|....:.....::.|   
Human   199 HLYIKSTSRVV---QRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVRE--- 257

  Fly   255 SFDLDKAEVIEDADLIYPELSMSYFVAIIVESFGMLHKVPDSLETLRVQIQTELLNVVRHTTHQL 319
               ::..::.||.:| .||.:.:.|:.|:::....|.|:|::::.:..:::.||..:|:.:|.|:
Human   258 ---INLQDIKEDLEL-DPEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQV 318

  Fly   320 SVSG------ATADTNP--LLSLLEVIFKQFKAIAKTHSLLLKNYLSVGQKYSVVGP-------Q 369
            :.||      .|.:..|  ||.|||::|.:|.|:|..||::| .||    :.:||.|       :
Human   319 ADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL-GYL----QDTVVTPLTQQEDIK 378

  Fly   370 PYDLTDFWAQAQSVLQLLLTDYLDIQN--AAADESAQTGFSEPTSNINSYFLRRKVPSTKRSMFK 432
            .||:.|.|.:.|.|||:|||:|||::|  .|::.|||..::.......::|.::|....|.|:||
Human   379 LYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFK 443

  Fly   433 FDKSSHVGTSNNSDAFKEHRRNASDAS------VDDNLAGQLGGSGKGSTSGLFPHEKKQREKIL 491
            |:.|||  ..:.|...:|.||.....|      .||||..  ||..|                 .
Human   444 FESSSH--AISMSAYLREQRRELYSRSGELQGGPDDNLIE--GGGTK-----------------F 487

  Fly   492 ICTPDQSIITKVYLPLMGYIKEIENFMKCKPGQPCSLHDFLDNYIKDTFLTKGHNR---NLQLTI 553
            :|.|....||.::.||:.:|:|||:.:...|.:.|.|.:||..|||:.||    |:   .:...|
Human   488 VCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFL----NQVLAEINKEI 548

  Fly   554 ESLSKNQDAWRTIISPEEIKALNLSRPLLQSTVMVERRLMETKNLIQDLPCYSEDLLKMVCALLK 618
            |.::|..|..:.:.:.:.:|.|.:.|||||||::||:.:.:..||:.||..||:..|.|||..|:
Human   549 EGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQ 613

  Fly   619 AYREICQAAYRGIVQPDSEDKRIYSVAWLKDEDISRFLKTLPNWTDLKTYSQKSRHNRKLHRGSF 683
            .|::.|.||||||||  ||:|.:.|.:|.||:||||.||:||||.::....|            .
Human   614 EYKDTCTAAYRGIVQ--SEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQ------------L 664

  Fly   684 EPSEEESPLQVQQRNIREAEMLTSNLGEGGITQQEILVEISVLKELAILQESMEWFSCRV-SEFA 747
            .|..||....::....:|:|:|..|||:..|..|:||.::|.||.||.:.||:||.:.|. |.|:
Human   665 RPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFS 729

  Fly   748 NDLRRPLVNGLNAVPAE---CGADI-AVKDGTIKVMTNLALEFDELANTCLLVLHLEVRVQCFHY 808
            |     |.......||:   ...|: .|.:..::.::.||..|.::|:.|||||||||||.||||
Human   730 N-----LSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHY 789

  Fly   809 LRSKSSVRTNSYVGSKDDILEPDRQVQVLTKRLSEMDEAFSATLHPRKTRYIFEGLAHLASRILI 873
            |...:.....:.|.:.:. ::.|..|..|.|.:|.::||.||:|...|.:||||||.||.|.|||
Human   790 LIPLAKEGNYAIVANVES-MDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILI 853

  Fly   874 QASNYLEHIDQITVQRMCRNAIALQQTLSNITASREVALDQARHFYELLCMEPDEILNALLERGT 938
            ..:.|...|.:..:::||||...|||.|:|||.|||..||.||.:||:|....||:||.::::|.
Human   854 NGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGV 918

  Fly   939 QFSEMQLLNALQLSCKS-FGITDANLLASYQQKLSDIL 975
            :::|::.::||.|..:| .|:.:.....:..|:|.:|:
Human   919 KYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEII 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec8NP_730996.2 Sec8_exocyst <32..143 CDD:281972 44/110 (40%)
L27 156..207 CDD:280918 20/50 (40%)
EXOC4NP_068579.3 Sec8_exocyst <57..143 CDD:281972 36/85 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154940
Domainoid 1 1.000 408 1.000 Domainoid score I700
eggNOG 1 0.900 - - E1_KOG3691
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40654
Inparanoid 1 1.050 547 1.000 Inparanoid score I1158
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55678
OrthoDB 1 1.010 - - D334342at33208
OrthoFinder 1 1.000 - - FOG0004885
OrthoInspector 1 1.000 - - oto89965
orthoMCL 1 0.900 - - OOG6_104006
Panther 1 1.100 - - LDO PTHR14146
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2520
SonicParanoid 1 1.000 - - X5225
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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