DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec8 and exoc4

DIOPT Version :9

Sequence 1:	NP_730996.2	Gene:	Sec8 / 40712	FlyBaseID:	FBgn0266672	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001025305.1	Gene:	exoc4 / 559866	ZFINID:	ZDB-GENE-041210-112	Length:	968	Species:	Danio rerio

Alignment Length:	1009	Identity:	351/1009 - (34%)
Similarity:	559/1009 - (55%)	Gaps:	116/1009 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VKYGKDESAGCGFLVNVIKSLGFSETTEERQKEKQKIEAEFKRSDLRLNELVSRHDQQLTQVLPL 77
            |...||.|   |.|::||::|..|:..::|:.||.::|..:::.|..|:||:.:|..:||..:..
Zfish    12 VSKSKDPS---GLLISVIRTLSSSDDVQDRETEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRT 73

  Fly    78 FSQVSSEVTASRERIHAVKENLGVCKRLLQCRRDELRKMWMDAVQHKYVLEMLEQIQELRKVPQR 142
            :..::..:|:||.:|..|||||..||.||.|:||||||:|::.|:||:||.:|::|:.:::|||:
Zfish    74 YQSITERITSSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGVEHKHVLSLLDEIENIKQVPQK 138

  Fly   143 VVGYTAKRQYLHASKALTDALTTLNGPLQAVEGLSDLRTDLQTRRQQLYQRLHEELVTQVYTNSA 207
            :....|.:.||||:..|..|:.:|.|||..||||.|||.:|.:::..::..|.:||...:|..|.
Zfish   139 LEASMASKHYLHATDMLVSAVDSLEGPLLQVEGLGDLRLELHSKKLNIHLVLIDELHRHLYIKST 203

  Fly   208 NEALSSFQR-----------TNSSRLNSSFTRGIGA-RRSTDRIEANARVRKALAEMAQSFDLDK 260
            :..:   ||           .:||.|:.|   |:.. |:.|:..:.:.....:|.|:
Zfish   204 SRVV---QRGKDKDKNRPAPKDSSVLDVS---GLSTPRKITEPSQFSTPGTSSLREV-------- 254

  Fly   261 AEVIEDADLIYPELSMSYFVAIIVESFGMLHKVPDSLETLRVQIQTELLNVVRHTTHQLS----- 320
            .|:.||.| :.||.:.:.|:.|::::...|.|:|::::.:..:::.||..:::.:|.|::
Zfish   255 QEMREDLD-VDPEENSAEFMGILIKALAKLKKIPETIKAIMERLEPELKQILKRSTTQIADHAYQ 318

  Fly   321 -VSGATADTNP--LLSLLEVIFKQFKAIAKTHSLLLKNYLSVGQKYSVVGP-------QPYDLTD 375
             ......|..|  ||.|||::|.:..|:|:.||::|.:...:     ||.|       :.|:..|
Zfish   319 RGESLAQDNQPRLLLELLELLFDKLNAVAQAHSVVLSHLQQI-----VVSPNGAQEGIKLYEQAD 378

  Fly   376 FWAQAQSVLQLLLTDYLDIQN--AAADESAQTGFSEPTSNINSYFLRRKVPSTKRSMFKFDKSSH 438
            .:|:.|:|||:||.||||::|  :||:.|||..::....:..::|.::|....|:|:|||:.|||
Zfish   379 VYAKIQTVLQVLLMDYLDVKNTRSAAEPSAQLSYASTGGDFGAFFAKKKPLRPKQSLFKFESSSH 443

  Fly   439 VGTSNNSDAFKEHRRNASDAS------VDDNLAGQLGGSGKGSTSGLFPHEKKQREKILICTPDQ 497
              ..:.|...:|.||.....|      .||||..  ||..|                 .:|.|..
Zfish   444 --AISMSAYLREQRRELYSKSGELQGGADDNLIE--GGETK-----------------FLCKPGA 487

  Fly   498 SIITKVYLPLMGYIKEIENFMKCKPGQPCSLHDFLDNYIKDTFLTKGHNRNLQLTIESLSKNQDA 562
            ..||.::.||:.:|:|||:.|.....:.|.|..||..||.|.||::..... ...||:::|..|.
Zfish   488 RNITVIFQPLLRFIQEIESRMGPAQAKQCQLRTFLTYYINDLFLSQVRTET-NKEIEAVTKASDP 551

  Fly   563 WRTIISPEEIKALNLSRPLLQSTVMVERRLMETKNLIQDLPCYSEDLLKMVCALLKAYREICQAA 627
            .:.:.:.:.:|.|.:.||||||||:||:.:.:..:|:|||..||...|:|||..||.|:|||..|
Zfish   552 LKILANADTMKTLGVQRPLLQSTVVVEKSIQDLMSLMQDLSAYSNQFLEMVCDKLKEYKEICNTA 616

  Fly   628 YRGIVQPDSEDKRIYSVAWLKDEDISRFLKTLPNW---TDLKTYSQKSRHNRKLHRGSFEPSEEE 689
            ||.|||  .|:|...|.:|.|||||||.|::||||   |..|...||........|.:|
Zfish   617 YRHIVQ--IEEKLTISASWAKDEDISRLLQSLPNWASMTQPKQLRQKREEEEDFTRAAF------ 673

  Fly   690 SPLQVQQRNIREAEMLTSNLGEGGITQQEILVEISVLKELAILQESMEWFSCRVSEFANDLRRPL 754
                     .:|:|:||.|||:..|.|.|||.::|.||.||.|||||||.:.|:..|.:.|  |.
Zfish   674 ---------AKESEVLTGNLGDKLIPQNEILRDVSDLKALANLQESMEWLATRLRSFFSSL--PH 727

  Fly   755 VNGLNAVPAECGADIAV-------KDGTIKVMTNLALEFDELANTCLLVLHLEVRVQCFHYLRSK 812
            .:.::.     |:|..|       ::..::.:|:|:..|.::|:.|||||||||||.|||||...
Zfish   728 SSSVSP-----GSDAQVNSESVRSREQILQTLTDLSRSFQDIADRCLLVLHLEVRVHCFHYLIPL 787

  Fly   813 SSVRTNSYVGSKDDILEPDRQVQVLTKRLSEMDEAFSATLHPRKTRYIFEGLAHLASRILIQASN 877
            :. :.|..:.:....::.|..|..|.|.:|.::|...|.|...|.:||||||.||.|.|||..:.
Zfish   788 AK-QGNYAIVANAASMDYDPLVVKLNKDISAIEEVMGAALQQHKFQYIFEGLGHLISCILINGAQ 851

  Fly   878 YLEHIDQITVQRMCRNAIALQQTLSNITASREVALDQARHFYELLCMEPDEILNALLERGTQFSE 942
            |.:.|.:..:::||||...|||.|:|||.|||..||.||.:||:|....||:||.::::|.:::|
Zfish   852 YFKRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVRYTE 916

  Fly   943 MQLLNALQLSCKS-FGITDANLLASYQQKLSDIL 975
            ::.:|||.|..:| .|:.|..:.....|:|.:|:
Zfish   917 LEYINALSLLHRSQTGVGDLTVQNMRLQRLKEII 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec8	NP_730996.2	Sec8_exocyst	<32..143	CDD:281972	44/110 (40%)
Sec8	NP_730996.2	L27	156..207	CDD:280918	18/50 (36%)
exoc4	NP_001025305.1	Sec8_exocyst	<55..140	CDD:281972	37/84 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589977
Domainoid	1	1.000	408	1.000	Domainoid score	I669
eggNOG	1	0.900	-	-		E1_KOG3691
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40654
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1102
OMA	1	1.010	-	-		QHG55678
OrthoDB	1	1.010	-	-		D334342at33208
OrthoFinder	1	1.000	-	-		FOG0004885
OrthoInspector	1	1.000	-	-		oto41125
orthoMCL	1	0.900	-	-		OOG6_104006
Panther	1	1.100	-	-	LDO	PTHR14146
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2520
SonicParanoid	1	1.000	-	-		X5225
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800