DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec8 and sec8

DIOPT Version :9

Sequence 1:	NP_730996.2	Gene:	Sec8 / 40712	FlyBaseID:	FBgn0266672	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001342752.1	Gene:	sec8 / 2539407	PomBaseID:	SPCC970.09	Length:	1073	Species:	Schizosaccharomyces pombe

Alignment Length:	1151	Identity:	245/1151 - (21%)
Similarity:	419/1151 - (36%)	Gaps:	322/1151 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RGVKYGKDESAGCGFLVNVI----KSLGFSETTEERQKEKQKIE--------AEFK-------RS 56
            ||:..|..|:     |||.|    |.||    .|:.|.....:|        .::|       |.
pombe    45 RGMHIGDLEN-----LVNEIEDEWKDLG----REDYQPISTALELLDDSSFGRDYKSFLNVYDRI 100

  Fly    57 DLRLNELVSRHDQQLTQVLPLFSQVSSEVTASRERIHAVKENLGVCKRLL-QCRRDELRKMWMDA 120
            ...|..:...|....|:.:..:.::...:.....||.|:|::|...:..: .....||::....:
pombe   101 SAALQTIAHTHKDDFTRGISAYGEIMEGIQKCNSRIIALKQSLEASQECIGNTNSKELQQTLARS 165

  Fly   121 VQHKYVLEMLEQIQELRKVPQRVVGYTAKRQYLHAS---KALTDAL--TTLNGPLQAVEGLSDLR 180
            .|:|.|:.:|:::.|..::..........:||.|||   :.:.|.|  :..:|.| .||......
pombe   166 SQYKKVISVLKELNEANQLFDNFHTLVDSKQYYHASDLIRRVWDELSRSDFDGIL-VVEQFKSRM 229

  Fly   181 TDLQTRRQQLYQRLHEELVTQVYTNSA-NEALSSFQRTNSSRLNSS--FTRGIGARRSTDRIEAN 242
            |.|.:..:.:   |.||||:..:...| ...:.|:...|..|..|:  |.|        |.::.|
pombe   230 TGLLSHLEDI---LSEELVSITFLKDAVAYPIVSYCSPNPLRETSNPYFLR--------DFLKNN 283

  Fly   243 ARVRKALAEMAQSFDLDKAEVIEDADLIYPELSMSY------FVAIIVESFGMLHKVPDSLETLR 301
            |.. ..|.:..|...|::|..::.:|.    |.|.|      .:.|::||..:|.|:|:::.:|:
pombe   284 ANT-STLGQSEQLRYLEEALSLKLSDC----LKMDYGRDSLRDIRIVLESLNLLGKLPNAISSLK 343

  Fly   302 VQIQTELLNVVRHTT----HQLSVSGATADTNP---------------------------LLSLL 335
            .:...|:...|..|:    ::.|:....:..||                           |.:.|
pombe   344 SRTSAEMFTTVDSTSRAIVNKYSLGNNVSTVNPFSKSLYDIGLHAETDREHTMISEFLTNLFTKL 408

  Fly   336 EVIFKQFKAIAKTHSLL---LKNYLSVGQKYSV--VGPQP-------YDLTDFWAQAQSVLQ--- 385
            ..:...::.|::..:.|   ...:.|...|.|:  |...|       :|.:|......::||
pombe   409 RCVLMHYRGISEFMTKLETKTPKHASSSHKSSIMSVNSDPTSPKVSKFDTSDSTFPFDTLLQAFE 473

  Fly   386 ----LLLTDYLDIQNAAADESAQTGFSEPTSNINSYFLRRKVPSTKRSMFKFDKSSHVGTSNNSD 446
                |:|.|||..:....:.|.........|..|       :|........||.::.:...|.|:
pombe   474 SEIRLMLKDYLISKEEYIENSGNFVVGTEMSIYN-------LPGENEEDKLFDVTNEIAVENKSN 531

  Fly   447 AF------------KEHRRNASDASVDDNLAGQLGGSGKGSTSGLFPHEKKQREK----ILICTP 495
            ||            .|...|.|:|||              ||..||....|:..:    ::...|
pombe   532 AFYARINELVNEKAPELILNKSNASV--------------STIELFSGSSKEIVRLAGHVVFVGP 582

  Fly   496 DQSIITKVYLPLMGYIKEIENFMKCKPGQPCSLHDFLDNYIKDTFLTKGHNRNLQLTIESLSKNQ 560
            .....:.|....:.::::..:.:| .|..|   ..|..|::|: ||...:...|   .:.:|.:.
pombe   583 SVFHASSVLPQTVFFLEDSVSILK-NPNIP---PQFAVNFMKE-FLRGSYIPQL---YKFMSSHF 639

  Fly   561 DAWRTIISPEEIKALNLSR--------PLLQSTV--------------MVERRLMETKNLIQDLP 603
            |   ||:  :::.|..|.|        |:.:..|              :|...|:|...|:..|.
pombe   640 D---TIM--KDVGAFQLHRDWKIYSKIPIFKCHVAIVQYFHDLQDYLPIVALNLVEFYELLHTLL 699

  Fly   604 C----YSEDLLKMVC--ALLKAYREICQAAYRGIVQPDSEDKRIYSVAWLKDEDISRFLKTLPNW 662
            .    :..|.|..:|  |:||.|:.         |..|:||........|..:|:     |.|.:
pombe   700 VRFRNHCSDYLSDLCRTAVLKEYKH---------VNEDTEDVDDTVRVKLLHDDV-----TYPQF 750

  Fly   663 TDLKTYSQKSRHNRKLHRGSFEPS----------EEESPLQVQQRNIREAEMLTSNLGEGGITQQ 717
              :|...||:            ||          |.:..||.:.|.|      ||
pombe   751 --IKFLKQKN------------PSLEGLNELCRMENKRLLQYEDRAI------TS---------- 785

  Fly   718 EILVEISVLKE-------LAILQESMEWFSCR-VSEFANDLRRPLVNGLNAVPAECGADIAVKDG 774
            |:.:.:|||.:       ::.|..|||||..| .|.|.|..||  :|.|....|..|.|....|.
pombe   786 EVKLPVSVLSKDSDLVNSVSYLHNSMEWFLQRCFSRFMNGSRR--MNVLQQNQANFGGDFLPIDN 848

  Fly   775 TI------------KVMTNL-ALEFDELANTCLLVLHLEVRVQCFHYLRSKSSVRTNSYVGSKDD 826
            .:            :|..:| .|:||     .||::.:|||:|..|.:        |..|...|.
pombe   849 LLGNNSDLMKGAYKEVFDSLQRLQFD-----ALLLIRMEVRLQYIHSI--------NQSVNLPDY 900

  Fly   827 ILE----PDRQVQVLTKRLSEMDEAFSATLHPRKTRYIFEGLAHLASRILIQASNYLEHIDQITV 887
            ::|    ||..:..|...:...:......|:..:.|::|:||:.|....|......:|.:::.:.
pombe   901 VVEYRGRPDASIMALNSTIVTTNLKLETCLNEWERRFVFQGLSELVDSSLYSIFYKIESMNRGSC 965

  Fly   888 QRMCRNAIALQQTLSNI----------TASREVALDQ------ARHFY-----ELLCMEPD--EI 929
            .:|.:|..|:.|.|..:          .:||...:.|      ..||.     |||   ||  ::
pombe   966 LQMLKNMSAMIQILKTVKEIHGDVEFPKSSRVFGIYQNGAKKIIEHFIAAPKKELL---PDVKQM 1027

  Fly   930 LNALLERGTQFSEMQLLNALQLSCKSFGITDANLLASYQQKLSDIL 975
            :....:|            |....|..|..|  |...||:|:..:|
pombe  1028 VRIYYQR------------LMKDAKRNGRDD--LYRQYQKKIGSVL 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec8	NP_730996.2	Sec8_exocyst	<32..143	CDD:281972	22/126 (17%)
Sec8	NP_730996.2	L27	156..207	CDD:280918	14/55 (25%)
sec8	NP_001342752.1	Sec8_exocyst	51..191	CDD:281972	28/148 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	54	1.000	Domainoid score	I3242
eggNOG	1	0.900	-	-		E1_KOG3691
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I1900
OMA	1	1.010	-	-		QHG55678
OrthoFinder	1	1.000	-	-		FOG0004885
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104006
Panther	1	1.100	-	-	LDO	PTHR14146
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2520
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.990