DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec8 and sec-8

DIOPT Version :9

Sequence 1:	NP_730996.2	Gene:	Sec8 / 40712	FlyBaseID:	FBgn0266672	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_492732.2	Gene:	sec-8 / 172924	WormBaseID:	WBGene00004753	Length:	893	Species:	Caenorhabditis elegans

Alignment Length:	1023	Identity:	262/1023 - (25%)
Similarity:	455/1023 - (44%)	Gaps:	229/1023 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GFLVNVIKSLGFSETTEERQKEKQKIEAEFKRSDLRLNELVSRHDQQLTQVLPLFSQVSSEVTAS 88
            |.|:|||:||..|.:.::|:.||.::|..:|.|...::.||..|.|.:.:.|..|..|||:::..
Worm    31 GLLINVIRSLTSSVSEDQREVEKSRLEKGYKESGALIDRLVKNHQQDVEKCLVSFRDVSSKISNC 95

  Fly    89 RERIHAVKENLGVCKRLLQCRRDELRKMWMDAVQHKYVLEMLEQIQELRKVPQRVVGYTAKRQYL 153
            |||||.|:..|...|.||:.|||:|:|:|.:..|.|.|.|::.:::|||:.|.::....:|.||.
Worm    96 RERIHNVRNALHTVKSLLELRRDDLKKLWHENAQQKSVCEIMAKLEELREAPSKIENLISKEQYQ 160

  Fly   154 HASKALTDALTTLNGPLQAVEGLSDLRTDLQTRRQQLYQRLHEELVT------------------ 200
            .|:..:|::...:||.|..|||||.|..:::...:.|..::::.||.
Worm   161 QAADTVTESRELINGRLSRVEGLSHLSAEIERFTKILIDKINDTLVNMLVVEPFEKHLLHIVRTI 225

  Fly   201 ---QVYTNSANEALSSFQRTNSSRLNSSFTRGIGARRSTDRIEANARVRKALAEMAQSFDLDKAE 262
               ::..|:...:||:..|:.|..: |||:......|....:||.:.:.:.:.|  :.:|:|:
Worm   226 PEHRINQNAYCHSLSTKSRSGSGSV-SSFSDVSAKSRIVSSVEALSTLFRTVEE--RHWDVDR-- 285

  Fly   263 VIEDADLIYPELSMSYFVAIIVESFGMLHK-VPDSLETLRVQIQTELLNVVRHTTHQLSVSGATA 326
                               :::....|:.| :.::::.:::....:..|              ..
Worm   286 -------------------LMMLGKNMIDKMIVNTVQVMKIGANIDESN--------------EG 317

  Fly   327 DTNPLLSLLEVIFKQFKAIAKTHS---LLLKNYLSVGQKYSVVGPQPYDLTDFWAQAQSVLQLLL 388
            ||..|..|::::..||.:.::.|:   :|::..|  |:|..|        |.||..|||.:::::
Worm   318 DTTHLKQLMQLLSAQFDSASQQHAEFGVLVEKQL--GRKDVV--------TSFWRSAQSAIEVVV 372

  Fly   389 TDYLDIQNAAADESAQTGFSEPTSNINSYFLRRKVPSTKRSMFKFDKSSHVGTSNNSDAFKEHRR 453
            :::||| |...::....|                 .::::.:|:|:.::....:.||.:
Worm   373 SEHLDI-NPLLEKQNVLG-----------------TASRKQLFRFENTACATPNANSSS------ 413

  Fly   454 NASDASVDDNLAGQLGGSGKGSTSGLFPHEKKQREKILICTPDQSIITKVYLPLMGYIKEIENFM 518
                                            .|.|.:||.|....| ||..|::..:  :|...
Worm   414 --------------------------------HRTKAVICKPSAYNI-KVIFPILSRL--METTE 443

  Fly   519 KCKPGQPCSLHDFLDNYIKDTFL--TKGHNRNLQLTIESLSKNQDAWRTI----ISPEEIKALNL 577
            |.....||.|..|:.:::.:.|:  .||   .|...||...:..:|.|..    |.|...|.|||
Worm   444 KNINDSPCELRRFMHSFVMEVFVERVKG---ELASRIEGALRGGEAVRVSTNKKILPSCEKVLNL 505

  Fly   578 SRPLLQSTVMVERRLMETKNLIQDLPCYSEDLLKMVCALLKAYREICQAAYRGIVQ-------PD 635
            .:              |.::||..:..|::....:...:|..|.:.....|..:..       |:
Worm   506 CK--------------EVQDLIVSIDLYADRFAALWLLVLTDYFKNMTDVYDRMTPKNPDPSLPN 556

  Fly   636 SE----DKRIYSVAWLKDEDISRFLKTLPNWTDLKTYSQKSRHNRKLHRGSFEPSEE--ESPLQV 694
            ||    .::..|.||..|:||||.|.:||||                |..|..|...  ||.|.|
Worm   557 SEALPTRRQKISAAWTADDDISRLLMSLPNW----------------HAASISPMTPAVESELDV 605

  Fly   695 QQRNIREAEMLTSNLG---EGGITQQEILVEISVLKELAILQESMEWFSCRVSEFANDLRRPLVN 756
            .:||.||:|:|..|||   :..:::.:::.:::.:|..|.|.||:.|||..:.|..:.|
Worm   606 GERNKRESEILIGNLGTQAQNSLSESDLITDMNDIKMFASLHESLRWFSDEIRELVHSL------ 664

  Fly   757 GLNAVPAE-------CGADIAVKDGTI-------KVMTNLALEFDELANTCLLVLHLEVRVQCFH 807
                 ||.       |...:.:|||.:       ..:.:.....:.:|::|||:||:|:||.||.
Worm   665 -----PANVKMMLDTCMVQVRLKDGQMIDNNSVPSAIEDCVRRLESIADSCLLLLHIEIRVHCFF 724

  Fly   808 YLRSKSSVRTNSYVGSKDDILEPDRQVQVLTKRLSEMDEAFSATLHPRKTRYIFEGLAHLASRIL 872
            :|...:..|..|   |.:::   |.:|..|.|.|.:..:.....|.|.|..|:|:||.||.:.:.
Worm   725 HLAPLAKYRNTS---SHNEV---DPEVVALGKDLHQFHDNLKDVLSPAKLSYVFDGLGHLCASLF 783

  Fly   873 IQASNYLEHIDQITVQRMCRNAIALQQTLSNITASREVALDQARHFYELLC-MEPDEILNALLER 936
            |..|.::..:.:...:|:|||...:||.||.||..||..||:||.|::||. ..||.||..:.|:
Worm   784 IHYSQFMPRLTEAAKKRVCRNVWGVQQRLSRITNRRESDLDRARAFFDLLLDNTPDGILAIVPEK 848

  Fly   937 GTQFSEMQLLNALQLSCKSFGITDANL------LASYQQKLSDILGAK 978
            .:||:..:|...|.||.:|    |..|      |...|..|:.||..|
Worm   849 RSQFTATELNYLLALSVRS----DKTLASQPGALEKRQMVLNSILNQK 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec8	NP_730996.2	Sec8_exocyst	<32..143	CDD:281972	42/110 (38%)
Sec8	NP_730996.2	L27	156..207	CDD:280918	14/71 (20%)
sec-8	NP_492732.2	Sec8_exocyst	<41..153	CDD:281972	40/111 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163589
Domainoid	1	1.000	188	1.000	Domainoid score	I1958
eggNOG	1	0.900	-	-		E1_KOG3691
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40654
Inparanoid	1	1.050	297	1.000	Inparanoid score	I1654
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55678
OrthoDB	1	1.010	-	-		D334342at33208
OrthoFinder	1	1.000	-	-		FOG0004885
OrthoInspector	1	1.000	-	-		oto19860
orthoMCL	1	0.900	-	-		OOG6_104006
Panther	1	1.100	-	-	LDO	PTHR14146
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2520
SonicParanoid	1	1.000	-	-		X5225
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800