DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2091 and DCS1

DIOPT Version :9

Sequence 1:	NP_649582.1	Gene:	CG2091 / 40711	FlyBaseID:	FBgn0037372	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_013372.1	Gene:	DCS1 / 850974	SGDID:	S000004260	Length:	350	Species:	Saccharomyces cerevisiae

Alignment Length:	327	Identity:	112/327 - (34%)
Similarity:	177/327 - (54%)	Gaps:	36/327 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSKFQLKRILTNNSVRKSISLLGTFPDLGTDDAIVVFEKNAYRESDVATASSEESPKKPSYFTA- 80
            :.:||...:|.:|...|.:|||||   :...|||:..||..:...:.....|::....|..:..
Yeast    12 IKRFQFVSVLDSNPQTKVMSLLGT---IDNKDAIITAEKTHFLFDETVRRPSQDGRSTPVLYNCE 73

  Fly    81 ----------DLKVDTEFINNIYGSFQVVPTQDLCS---VKSTVIYPATEKHIEKYSVSQKYLIR 132
                      :||..|.  |:||.....|..||:.|   .|..:|:|||..||:||.....:|:|
Yeast    74 NEYSCINGIQELKEITS--NDIYYWGLSVIKQDMESNPTAKLNLIWPATPIHIKKYEQQNFHLVR 136

  Fly   133 ETPDLYQRITLPYLTS--SQFSLEWVYNILEHKQETERIVYED---RDPKTGFILLPDLKWDGRN 192
            |||::|:||..||:..  :...|:||.|||....|:||:||:|   .:...||::|||:||||.|
Yeast   137 ETPEMYKRIVQPYIEEMCNNGRLKWVNNILYEGAESERVVYKDFSEENKDDGFLILPDMKWDGMN 201

  Fly   193 VETLYLLGIVHKRDIKSLRDLNESHLDLLRNVRQASKDAIAKL--YGINPNQLRMYFHYQPSFYH 255
            :::|||:.||::.|||::|||..|....|.|:....:..:...  |.::|::||:..|||||:||
Yeast   202 LDSLYLVAIVYRTDIKTIRDLRYSDRQWLINLNNKIRSIVPGCYNYAVHPDELRILVHYQPSYYH 266

  Fly   256 LHVHINPVRNDAPG--IWCEKSHMLDTVINNLE-LMPDYYQRATLPFVLYEGNKLLDLY----EQ 313
            .|:||..:::...|  |...|:.:|:.:|..|. |.|:.|...|:.:.:.|.:   ||:    |:
Yeast   267 FHIHIVNIKHPGLGNSIAAGKAILLEDIIEMLNYLGPEGYMNKTITYAIGENH---DLWKRGLEE 328

  Fly   314 EL 315
            ||
Yeast   329 EL 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2091	NP_649582.1	DcpS	15..124	CDD:283339	35/120 (29%)
		COG5075	17..307	CDD:227407	107/313 (34%)
		DcpS_C	155..260	CDD:288796	47/109 (43%)
DCS1	NP_013372.1	COG5075	1..330	CDD:227407	110/325 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346010
Domainoid	1	1.000	122	1.000	Domainoid score	I1238
eggNOG	1	0.900	-	-		E1_COG5075
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I960
Isobase	1	0.950	-	0	Normalized mean entropy	S1689
OMA	1	1.010	-	-		QHG58249
OrthoFinder	1	1.000	-	-		FOG0005125
OrthoInspector	1	1.000	-	-		otm46795
orthoMCL	1	0.900	-	-		OOG6_104575
Panther	1	1.100	-	-	LDO	PTHR12978
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R300
SonicParanoid	1	1.000	-	-		X3646
TreeFam	1	0.960	-	-
	15	14.740