DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and CDC5

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_013714.1	Gene:	CDC5 / 855013	SGDID:	S000004603	Length:	705	Species:	Saccharomyces cerevisiae

Alignment Length:	540	Identity:	126/540 - (23%)
Similarity:	204/540 - (37%)	Gaps:	135/540 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 VQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFL 204
            |..||::..|::::.:.::..: ..:.|.|||:|...:.|..     .|..:.|...:|||.:.|
Yeast   112 VAKASIKSEKTRKKLLSEIQIH-KSMSHPNIVQFIDCFEDDS-----NVYILLEICPNGSLMELL 170

  Fly   205 KRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGSVVPDAVH 269
            ||    .|.|.....|.:.|||..|:.|:|  |..:||.:|...:||...|..:|||.
Yeast   171 KR----RKVLTEPEVRFFTTQICGAIKYMH--SRRVIHRDLKLGNIFFDSNYNLKIGD------- 222

  Fly   270 YSVRRGRERERERER---GAHYFQAPE--YGAADQLTAALDIYAFGMCALEMAALEIQPSNSEST 329
            :.:......|.||:.   |...:.|||  .|.....:..:||::.|:.   :.||.|.....::.
Yeast   223 FGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVM---LYALLIGKPPFQAR 284

  Fly   330 AINE--ETIQRTIFSLENDLQ-----RDLIRKCLNPQPQDRPSANDLL--------FHPLLFEVH 379
            .:|.  |.|:...||...|..     :.|||..|:..|.:|||..:::        |.|.:
Yeast   285 DVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRGTFPPSI---- 345

  Fly   380 SLKLLTAHCLVFSPANRTMFSETA-FDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLE 443
                         |:  |:.||.. |:.:.:.       .:.:......|:...|..:| :||::
Yeast   346 -------------PS--TVMSEAPNFEDIPEE-------QSLVNFKDCMEKSLLLESMS-SDKIQ 387

  Fly   444 K----FVEDVKYGVYPLITYSGKKPPNFRSRAASPERADSVKSATPEPVDTESRRIVNMMC---- 500
            :    ::..:|..:..|..|...:|  |...:.||   ...|....|.||.|::|.:|.:.
Yeast   388 RQKRDYISSIKSSIDKLEEYHQNRP--FLPHSLSP---GGTKQKYKEVVDIEAQRRLNDLAREAR 447

  Fly   501 ------SVKIKE----DSNDITMTILLRMDDKMNRQLTCQVNENDTAADLTSE--LVRLGFVHLD 553
                  :|..||    .:|.|...|.||:                    |.||  |...|.|..:
Yeast   448 IRRAQQAVLRKELIATSTNVIKSEISLRI--------------------LASECHLTLNGIVEAE 492

  Fly   554 DQDKIQVLLEETL-----------------KAGVMSDGAGAESSGAGVTTTATMAALEQLERNWS 601
            .|.|:..|.:..|                 |.| .|.....|..|.......|:..|...|..|.
Yeast   493 AQYKMGGLPKSRLPKIKHPMIVTKWVDYSNKHG-FSYQLSTEDIGVLFNNGTTVLRLADAEEFWY 556

  Fly   602 ISSDADKQG-TAVMYVPQEQ 620
            ||.| |::| .|..|:..|:
Yeast   557 ISYD-DREGWVASHYLLSEK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	67/255 (26%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	67/254 (26%)
CDC5	NP_013714.1	STKc_PLK	80..337	CDD:271001	65/246 (26%)
		POLO_box_1	510..601	CDD:240561	17/68 (25%)
		POLO_box_2	613..698	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000