DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and WNK10

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_176644.2	Gene:	WNK10 / 842771	AraportID:	AT1G64630	Length:	524	Species:	Arabidopsis thaliana

Alignment Length:	575	Identity:	140/575 - (24%)
Similarity:	225/575 - (39%)	Gaps:	150/575 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 DESEILEESPCGRWLKRREEVDQRDVPG---IDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEE 153
            :|::.:::.|.||:::      ..||.|   ...|:.|.|..||:||.||.:....:.::..|.:
plant     2 EEADFVQKDPTGRYIR------YNDVLGRGAFKTVYKAFDEVEGIEVAWNLMSIEDVLQMPGQLD 60

  Fly   154 KMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLES 218
            ::......|..|.|.||:|....|.|.....   :..|||..:||||..:.|:    .:::..::
plant    61 RLYSEVHLLNSLKHDNIIKLFYSWVDDHNKS---INMITELFTSGSLTLYRKK----HRKVDPKA 118

  Fly   219 WRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHN-GLVKIGSVVPDAVHYSVRRGRERERER 282
            ...|..|||..|.||||.:||:||.:|.||:||:..| |.||||.:...||         .::..
plant   119 IMNWARQILKGLHYLHSQTPPVIHRDLKCDNIFVNGNTGKVKIGDLGLAAV---------MQQPT 174

  Fly   283 ER---GAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALE---------IQPSNSESTAINEET 335
            .|   |...|.|||. ..::....:|||:||||.|||...|         .|.....::.|..::
plant   175 ARSVIGTPEFMAPEL-YEEEYNELVDIYSFGMCMLEMVTCEYPYRECRNQAQIYKKVTSGIKPQS 238

  Fly   336 IQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFS 400
            :.:    :::...:..|.|||.|.| .||:|.:||...|| .|...|          .:..|..|
plant   239 LSK----VDDPQVKQFIEKCLLPAP-SRPTALELLKDQLL-AVDGAK----------DSTLTASS 287

  Fly   401 ETAFDGLM--QRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKK 463
            .|.|...|  |..|:|                                .||:|
plant   288 NTTFKPAMPPQCEYRP--------------------------------MDVEY------------ 308

  Fly   464 PPNFRSRAASPERADSVKSATPEPVDTESRRIVNMMCSVKIK---EDSNDITMTILLRM--DDKM 523
                 .:..|.....|.|| :.|....::..:..:..|.:.|   |..:|:..::.||:  ....
plant   309 -----KKNTSVSICSSAKS-SQECALLQTMEVQRVAESTEFKLSGERRDDVAASMALRIAGSSGQ 367

  Fly   524 NRQLTCQVN-ENDTAADLTSELVRLGFVHLD-DQDKIQVLLE----------------------- 563
            .|::....| :.|||..:|.|:|.    .|| ...::.|:.|
plant   368 ARKVDFDFNLKTDTARAVTGEMVE----ELDLSSHEVTVIAEMIDELIMKLKANRSLPNANSVYQ 428

  Fly   564 -------ETLKAGVMSDGAGAESSGAGVTTTATMAALEQLERNW--SISSDADKQ 609
                   |::|:.:.:|.....||..|........|:|.|..::  |.|..::||
plant   429 SKDEEAGESMKSEISADYYHRVSSNEGSRLGCCCEAVESLLSSFLDSCSMVSNKQ 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	86/277 (31%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	82/264 (31%)
WNK10	NP_176644.2	STKc_WNK	14..273	CDD:270885	86/286 (30%)
WNK10	NP_176644.2	S_TKc	20..273	CDD:214567	85/274 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D695382at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020