DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and WNK7

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001321455.1	Gene:	WNK7 / 841339	AraportID:	AT1G49160	Length:	604	Species:	Arabidopsis thaliana

Alignment Length:	640	Identity:	158/640 - (24%)
Similarity:	243/640 - (37%)	Gaps:	182/640 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DDSEDES--------EILEESPCGRWLKRREEVDQ---RDVPGIDCVHL---------------- 125
            :.|||.|        |:||..|..|:::.:|.:.:   :.|....|..|
plant     2 EGSEDASAIVEPPDPEVLEIDPTCRYIRYKEVIGKGASKTVYPFLCFSLHNLCFCFTICYSVLCD 66

  Fly   126 -------------------------AMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQL 165
                                     ..|..:|:||.||:|:...|.:.....|::......|..|
plant    67 IIVCATRGYEIHYFFNSLEQIISFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSL 131

  Fly   166 DHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSAL 230
            .|:||::|:..|.|.   :...|..|||..:||||:|:.|:    .:::.:::.:.|..|||:.|
plant   132 KHKNIIRFYNSWIDD---KNKTVNIITELFTSGSLRQYRKK----HRKVNMKAVKCWARQILTGL 189

  Fly   231 SYLHSCSPPIIHGNLTCDSIFIQHN-GLVKIG-----SVVPDAVHYSVRRGRERERERERGAHYF 289
            .||||..|||||.::.||:|||..| |.||||     :|:..|...||           .|...|
plant   190 KYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSV-----------IGTPEF 243

  Fly   290 QAPE-YGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTA-----INEETIQRTIFSLENDLQ 348
            .||| |.  :......|||:||||.|||...|.......::|     ::......::..:::...
plant   244 MAPELYD--ENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEV 306

  Fly   349 RDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLMQRYYQ 413
            ...|.|||.| ..:|.||.:||....| .|:.|.:.....|
plant   307 MKFIEKCLLP-ASERLSAEELLLDSFL-NVNGLVMNNPLPL------------------------ 345

  Fly   414 PDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNFRSRAAS----- 473
            ||:||.                              |.|.:.......:.|||.|:|..|
plant   346 PDIVMP------------------------------KEGSFGERCLMSEGPPNARNRTMSMNLDE 380

  Fly   474 ----PERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQLTCQ---V 531
                |....|..|.|.   ..|.||.......|...|::::.:::::||:.|:..|.....   .
plant   381 DNNLPIVISSNNSGTN---CIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFF 442

  Fly   532 NENDTAADLTSELVRLGFVHLDDQDK--------IQVLLEETL---KAGVMSD----GAGAESSG 581
            .|.|||::::||:|.    .|:..||        |.|||...:   |..|..|    ....:||.
plant   443 QEGDTASNVSSEMVE----QLELTDKNVKFIAELIDVLLVNLIPNWKTDVAVDHLIHPQQNQSSK 503

  Fly   582 AGVTTTATMAALEQLERNWSISSD----ADKQGTAVMYVPQEQQNAD--GDVDVE 630
            ......|:..|.|.:..  |:|||    :|.:....:....|.|.|:  |.::.|
plant   504 DNHQNGASSQAGESISH--SLSSDYCPRSDDEANPTVAATTEDQEAEKPGSLEEE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	87/317 (27%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	85/304 (28%)
WNK7	NP_001321455.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D695382at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020