DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and WNK8

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_568599.1	Gene:	WNK8 / 834204	AraportID:	AT5G41990	Length:	563	Species:	Arabidopsis thaliana

Alignment Length:	580	Identity:	142/580 - (24%)
Similarity:	241/580 - (41%)	Gaps:	147/580 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 SEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEK 154
            |.:|::..|:.|.||:: |.::|..|.  ....|:.|.|..:|:||.||.|....:.::..|.|:
plant    13 SMEEADFAEKDPSGRYI-RYDDVLGRG--AFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLER 74

  Fly   155 MRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVV-FITEYMSSGSLKQFLKRTKRNAKRLPLES 218
            :......|..|.|:||:|....|.|    |:.:.: .|||..:||||:.:.|:    .:::..::
plant    75 LYSEVHLLKALKHENIIKLFYSWVD----EKNKTINMITELFTSGSLRVYRKK----HRKVDPKA 131

  Fly   219 WRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHN-GLVKIG-----SVVPDAVHYSVRRGRE 277
            .:.|..|||..|:||||.:||:||.:|.||:||:..| |.||||     :|:......||
plant   132 IKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSV----- 191

  Fly   278 RERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTAINEETIQRTIFS 342
                  .|...|.|||. ..::....:|||:||||.|||...| .|.|.   ..|:..|.:.:.|
plant   192 ------IGTPEFMAPEL-YEEEYNELVDIYSFGMCMLEMVTCE-YPYNE---CRNQAQIYKKVTS 245

  Fly   343 ---------LENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTM 398
                     :::...|..|.|||.| ...||:|.:|...|.|
plant   246 NIKPQSLGKVDDPQVRQFIEKCLLP-ASSRPTALELSKDPFL----------------------- 286

  Fly   399 FSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKK 463
                |.|                   ||::.    |.::.:....|:|                :
plant   287 ----ARD-------------------GGKDS----ALLASSSTSSKYV----------------R 308

  Fly   464 PPNFRSRAASPERADSVKSAT-----PEPVDTESRRIVNMMCSVKIK-EDSNDITMTILLRMDDK 522
            ||.........:..:: ||.:     |.....|.:||.... ..::: |.|:|:|.:::||:.|.
plant   309 PPQLEHLPMDVDHNEN-KSVSSNEDYPWSQTIELQRIAENK-EFRLRGERSDDVTASMVLRIADP 371

  Fly   523 MNRQLTCQV------NENDTAADLTSELVRLGFVHLDDQDKIQV--LLEETLKAGVMSDGAGAES 579
            ..:   |::      .|:|||..:..|:|.  .:||..|:.:.:  ::::.:.. ::||...:..
plant   372 SGK---CRIVHFAFYLESDTATAIAEEMVE--ELHLTSQEVVVIADMIDDFIMQ-LLSDRTSSHH 430

  Fly   580 SGAGVTTT---------ATMAALEQLERNWSISSDADKQGTAVMYVPQEQQNADGDVDVE 630
            :......|         .|:.:.::.....|:.||.    :|..|.|....  ||:..:|
plant   431 NQNSPRLTHEDHEAANQQTVNSKDEEAAGQSMKSDI----SADYYFPYSAN--DGNAAME 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	88/277 (32%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	87/267 (33%)
WNK8	NP_568599.1	STKc_WNK	27..286	CDD:270885	91/286 (32%)
WNK8	NP_568599.1	S_TKc	33..286	CDD:214567	89/279 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D695382at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020