DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and WNK5

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001190056.1	Gene:	WNK5 / 824326	AraportID:	AT3G51630	Length:	549	Species:	Arabidopsis thaliana

Alignment Length:	543	Identity:	138/543 - (25%)
Similarity:	231/543 - (42%)	Gaps:	101/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ESGDDSEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELK 149
            |....|:|....:|..|.||:.:.||.:.:   ..:..|:.|.|...|:||.||:|:   |.|:.
plant     4 EISSASDDSIAYVETDPSGRYGRFREVLGK---GAMKTVYKAFDQVLGMEVAWNQVK---LNEVF 62

  Fly   150 SQEEKMRQVFDN---LLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNA 211
            ...|.:::::..   |..|:|::|:::...|.|   ..|....||||..:||:|:::    :|..
plant    63 RSPEPLQRLYSEVHLLKNLNHESIIRYCTSWID---VNRRTFNFITELFTSGTLREY----RRKY 120

  Fly   212 KRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQ-HNGLVKIGSVVPDAVHYSVRRG 275
            :::.:.:.:.|..|||:.|:|||...||:||.:|.||:||:. |.|.||||    |....::.||
plant   121 QKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIG----DLGLAAILRG 181

  Fly   276 RERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTA-----INEET 335
            .:.... ..|...|.|||....| ....:|||:||||.|||...|...|...:.|     :....
plant   182 SQNAHS-VIGTPEFMAPELYEED-YNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGK 244

  Fly   336 IQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVH--------------SLKLLTA 386
            :..:...:::...:..:.|||....:..| |.:||..|.|....              :::.|.|
plant   245 LPDSFHLIQHTEAQRFVGKCLETVSRRLP-AKELLADPFLAATDERDLAPLFRLPQQLAIQNLAA 308

  Fly   387 HCLVF-------SPANRT-------MFSE--TAF--------DGLMQRYYQPDVVMAQLRLAGGQ 427
            :..|.       .|...|       |.||  |.|        ||.|:....|..:::...|....
plant   309 NGTVVEHLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDGHMRNIQFPFNILSDTPLEVAL 373

  Fly   428 ERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNFRSRAASPERADSVKSATPEPVDTES 492
            |....| :::..|.|| ....::..:..|:       ||:|:..:|............:..|||.
plant   374 EMVKEL-EITDWDPLE-IAAMIENEISLLV-------PNWRANDSSIRHESFGHEDDEDNGDTEG 429

  Fly   493 R-RIVNMMCS-----VKIKEDSNDITMTILLRMDD---KMNRQLTCQVNENDTAADLTSELVRLG 548
            | |:.:...|     |.::|:::|.:..::..|||   ..||.|.........|.|
plant   430 RTRLFSSASSSHDSPVAVRENNDDSSNDVIPDMDDGNRSSNRLLNSSTYHYSPAID--------- 485

  Fly   549 FVHLDDQDKIQ---VLLEETLKA 568
                |||::.|   |.|::.:::
plant   486 ----DDQNQQQRRRVRLQQKMRS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	80/270 (30%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	80/260 (31%)
WNK5	NP_001190056.1	STKc_WNK	23..283	CDD:270885	83/279 (30%)
WNK5	NP_001190056.1	OSR1_C	<357..398	CDD:403428	7/42 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D695382at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020