DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and WNK3

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_680105.1	Gene:	WNK3 / 823984	AraportID:	AT3G48260	Length:	516	Species:	Arabidopsis thaliana

Alignment Length:	556	Identity:	139/556 - (25%)
Similarity:	214/556 - (38%)	Gaps:	157/556 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DDSEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEV----QYASLQEL 148
            |::..|.|.:|..|.||:.:.:|.:.:   .....|:.|.|..||:||.||:|    ::.|.::|
plant     4 DENNSEEEFVEIDPTGRYGRYKEVLGK---GAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDL 65

  Fly   149 KSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKR 213
                :::......|..|.|::|:||:..|.|.|..   .:..|||..:||:|:|:.|:    .|.
plant    66 ----DRLYSEVHLLKTLKHKSIIKFYTSWIDHQHM---TINLITEVFTSGNLRQYRKK----HKC 119

  Fly   214 LPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHN-GLVKIGSVVPDAVHYSVRRGRE 277
            :.|.:.::|..|||..|.||||..||:||.:|.||:|||..| |.||||.:...|:.:     |.
plant   120 VDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILH-----RA 179

  Fly   278 RERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTAINEETIQRTIFS 342
            |......|...|.|||....| ....:||||||||.||:...|.  ..||.|  |...|.|.:.|
plant   180 RSAHSVIGTPEFMAPELYEED-YNVLVDIYAFGMCLLELVTFEY--PYSECT--NAAQIYRKVTS 239

  Fly   343 ---------LENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTM 398
                     :.:...|..|.||:....| |.||.:||..|.|           .|...:..|.:.
plant   240 GIKPAALLNVTDPQVRAFIEKCIAKVSQ-RLSAKELLDDPFL-----------KCYKENTENVSS 292

  Fly   399 FSETAF--DGLMQRYYQPDV--------------VMAQLRL--AGGQERQYR------------- 432
            ..|..:  :|::.:....:|              :..:||:  :.||.|...
plant   293 HKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSV 357

  Fly   433 ---------------------------------------LADVSGADK---------LEKFVEDV 449
                                                   :.|.|...|         |::|....
plant   358 AIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDWTPSRLIGDDSAVQKCLSSPETLHLDRFPSGR 422

  Fly   450 KYGVYPLITYSGKKPPNFRSRAASPERADSVKSATPEPVDTESRRIVNMMCSVK----------- 503
            |:       :|..|.....||:....|::|..|:...|::.|...||..:.|:.
plant   423 KF-------WSSPKAGAGDSRSPFAPRSNSKLSSAQGPINQEVGVIVEKLESLLRKQREEIEEMQ 480

  Fly   504 ----------IKEDSNDITMTILLRMDDKMNRQLTC 529
                      :||...:|....|:|:..|.:..|.|
plant   481 RDQERIVTEFLKEFPPEICEEALVRLQVKDSDNLLC 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	94/275 (34%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	94/265 (35%)
WNK3	NP_680105.1	STKc_WNK	20..280	CDD:270885	96/284 (34%)
WNK3	NP_680105.1	S_TKc	26..280	CDD:214567	95/278 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D695382at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020