DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and WNK6

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001189928.1	Gene:	WNK6 / 821406	AraportID:	AT3G18750	Length:	567	Species:	Arabidopsis thaliana

Alignment Length:	527	Identity:	141/527 - (26%)
Similarity:	225/527 - (42%)	Gaps:	121/527 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ESGDDSE-----DESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYAS 144
            |..||:.     .:.|:||..|..|:::.:|.:.:   .....|:.|.|..:|:||.||:|:...
plant     2 EGTDDASALQEPPDPEVLEVDPTFRYIRYKEVIGK---GAFKTVYKAFDEVDGIEVAWNQVRIDD 63

  Fly   145 LQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKR 209
            :.:..:..|::......|..|.|.||::|:..|.|.   :...|..|||..:||||:.:.|:
plant    64 VLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDD---KNKTVNIITELFTSGSLRHYRKK--- 122

  Fly   210 NAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHN-GLVKIG-----SVVPDAV 268
             .:::.:::.:.|..|||..|.|||...|||||.:|.||:|||..| |.||||     :|:..|.
plant   123 -HRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQAN 186

  Fly   269 HYSVRRGRERERERERGAHYFQAPE-YGAADQLTAALDIYAFGMCALEMAALE---IQPSNSE-- 327
            ..||           .|...|.||| |.  :......|||:||||.|||...:   .:..||.
plant   187 AKSV-----------IGTPEFMAPELYD--ENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQI 238

  Fly   328 ----STAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHC 388
                |:.|...::.|    :::...:..|.|||.| ..:|.||.:||..|.| :::.|
plant   239 YKKVSSGIKPASLSR----VKDPEVKQFIEKCLLP-ASERLSAKELLLDPFL-QLNGL------- 290

  Fly   389 LVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFV-----ED 448
                    ||.:....         ||:||.:   .|....:..:::.....:..|.:     ||
plant   291 --------TMNNPLPL---------PDIVMPK---EGAFGDRCLMSEGPPTTRPSKTLSIDLDED 335

  Fly   449 VKYGVYPLITYSGKKPPNFRSRAASPERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSNDITM 513
            ..   .|::|:|    .|..||.                  .|.||.......|...|::::.::
plant   336 SN---LPIVTFS----DNSGSRC------------------IEVRRAKRGNFFVLKGEENDEQSV 375

  Fly   514 TILLRMDDKMNRQLTCQ---VNENDTAADLTSELVRLGFVHLDDQ------DKIQVLLEE---TL 566
            :::||:.|:..|.....   ..|.|||:.::||:|..  :.|.||      :.|.:||..   |.
plant   376 SLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQ--LELTDQNVTFIAELIDILLVNMIPTW 438

  Fly   567 KAGVMSD 573
            |..|..|
plant   439 KTDVTVD 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	88/277 (32%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	88/267 (33%)
WNK6	NP_001189928.1	STKc_WNK	26..285	CDD:270885	90/286 (31%)
WNK6	NP_001189928.1	S_TKc	32..285	CDD:214567	89/280 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D695382at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020