Protein Alignment Madm and nrbp2

DIOPT Version :10

• Sequence 1: NP_649581.1
• Gene: Madm / 40710
• FlyBaseID: FBgn0027497
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: XP_031759312.1
• Gene: nrbp2 / 779874
• XenbaseID: XB-GENE-5826617
• Length: 468
• Species: Xenopus tropicalis
• Alignment Length: 480
• Identity: 222/480 - (46%)
• Similarity: 316/480 - (65%)
• Gaps: 39/480 - (8%)

  Fly   100 SPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQ 164
            :||     .:.:|:|.::|||:..:|||||||||||||||:|::..:..|:.|||::.:|.||:.
 Frog     3 APC-----YQLQVNQGNMPGIESTYLAMDTEEGVEVVWNELQFSDKKIFKAHEEKIKNLFQNLMV 62

  Fly   165 LDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSA 229
            :||.|:||||:||.|.|:.. .|:||||||:|||||:||||:||:|.|.:...:|:|||||||||
 Frog    63 IDHPNVVKFHKYWPDVQETS-ARLVFITEYVSSGSLRQFLKKTKKNRKTMNSRAWKRWCTQILSA 126

  Fly   230 LSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGSV----------VPDAVHYSVRRGRERERERER 284
            |||||.|.|||||||||.|:||||||||:|||||          |||    .:|...:.:||..|
 Frog   127 LSYLHCCDPPIIHGNLTSDTIFIQHNGLIKIGSVWHRVFAHELPVPD----DLRTPLKIQREEHR 187

  Fly   285 GAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTAINEETIQRTIFSLENDLQR 349
            ..|:| .||:|..:..| |:|||:|||||||||.|||| ||.|.  ::|:.|.|.:.|||:...:
 Frog   188 TLHFF-PPEFGYLEDGT-AMDIYSFGMCALEMAVLEIQ-SNGEK--VSEDNIIRAVHSLEDLNMK 247

  Fly   350 DLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSP--ANRTMFSETA--FDGLMQR 410
            |.|.:||:..|:.||||::||||.:||||||||||.|||.:.:|  |..|:..|..  .|.|
 Frog   248 DFIEQCLSVAPEKRPSAHNLLFHRVLFEVHSLKLLAAHCFLNTPYIAQDTLLEEKTKRIDAL--- 309

  Fly   411 YYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNF-RSRAASP 474
                 .|.|.:.........:|.:.||..: |:||:||::.|::||:.::..:|..| |....|.
 Frog   310 -----GVFASVPRKAHARIIWRYSQVSSME-LDKFLEDIRNGLFPLMNFTDCRPQIFPRGLPQSQ 368

  Fly   475 ERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQLTCQVNENDTAAD 539
            |.....|:.||||::.|:|:|:.|.|:::.|||.....:|:.|:::|||:|.|:|.:..:::...
 Frog   369 EDLHVTKTPTPEPMEVETRKIIQMNCNLERKEDRARWHLTLYLKLEDKMHRHLSCDLLPDESCES 433

  Fly   540 LTSELVRLGFVHLDDQDKIQVLLEE 564
            |.||||:.||:..:|:.|:.:.|||
 Frog   434 LASELVQYGFISQEDRQKMALFLEE 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_649581.1	PK_NRBP1_like	114..376	CDD:270886	149/271 (55%)
nrbp2	XP_031759312.1	Protein Kinases, catalytic domain	12..274	CDD:473864	149/271 (55%)