DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Madm and Nrbp2

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_006241947.1	Gene:	Nrbp2 / 680451	RGDID:	1591749	Length:	499	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	246/495 - (49%)
Similarity:	326/495 - (65%)	Gaps:	31/495 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RESGDDSEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQEL 148
            ||..|:|||||:||||||||||.||||:|:|.::|||....|||||||||||||||:.:...:..
  Rat    14 REREDESEDESDILEESPCGRWQKRREQVNQGNMPGIQSTFLAMDTEEGVEVVWNELHFGDRKAF 78

  Fly   149 KSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKR 213
            .:.|||::.:|:.|..:||.||||.|:||.|..:| |.||:|||||:||||||||||:||:|.|.
  Rat    79 AAHEEKIQTMFEQLALVDHPNIVKLHKYWLDASEA-RARVIFITEYVSSGSLKQFLKKTKKNHKA 142

  Fly   214 LPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGSV--------VPDAVHY 270
            :...:|:|||||||||||:||:|||||||||||.|:||||||||:|||||        :||.:..
  Rat   143 MNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWYRIFSNALPDDLRS 207

  Fly   271 SVRRGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTAINEET 335
            .:|    .|||..|..|:| .||||..:..| |:||::|||||||||.||||.:.  .|.:.||.
  Rat   208 PIR----TEREELRNLHFF-PPEYGEVNDGT-AVDIFSFGMCALEMAVLEIQANG--DTRVTEEA 264

  Fly   336 IQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLV----FSPANR 396
            |.|...||.:...|:.|..||...|..||||::||||.:||||||||||.|||.:    ..|.|.
  Rat   265 IARARHSLSDPNMREFILSCLARDPARRPSAHNLLFHRVLFEVHSLKLLAAHCFIQHQYLMPENV 329

  Fly   397 TMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSG 461
            ......|.|        ...|:|::....|...|:|.::||..: |:||:|||:.|:|||:.::.
  Rat   330 VEEKTKAMD--------LHAVLAEMPQPHGPPMQWRYSEVSFLE-LDKFLEDVRNGIYPLMNFAA 385

  Fly   462 KKPPNF-RSRAASPERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNR 525
            .:|... |..|..||.|...|:.||||.|:|:|::|.|.|:::..||.....:|:||.::|:::|
  Rat   386 ARPLGLPRVLAPPPEEAQKAKTPTPEPFDSETRKVVQMQCNLERSEDKARWHLTLLLVLEDRLHR 450

  Fly   526 QLTCQVNENDTAADLTSELVRLGFVHLDDQDKIQVLLEET 565
            |||..:...|:|.||.:|||..||:|.||:.|:...||.|
  Rat   451 QLTYDLLPTDSAQDLAAELVHYGFLHEDDRTKLAAFLETT 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	146/269 (54%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	142/259 (55%)
Nrbp2	XP_006241947.1	PK_MADML	44..305	CDD:270937	146/269 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335051
Domainoid	1	1.000	277	1.000	Domainoid score	I1655
eggNOG	1	0.900	-	-		E1_KOG1266
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233882at33208
OrthoFinder	1	1.000	-	-		FOG0002915
OrthoInspector	1	1.000	-	-		otm44849
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860