Protein Alignment Madm and WNK4

DIOPT Version :9

• Sequence 1: NP_001303420.1
• Gene: Madm / 40710
• FlyBaseID: FBgn0027497
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: XP_016880451.1
• Gene: WNK4 / 65266
• HGNCID: 14544
• Length: 1302
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 121/409 - (29%)
• Similarity: 179/409 - (43%)
• Gaps: 83/409 - (20%)

  Fly    10 ISGSTVADEPIQHHPSLAAGPVSASCPAATPPSQSTQQP--------PPHIVSASTADAGSSAAV 66
            :..|...|.|   .|..:|||    .||.:||..|.:.|        |......|.......:||
Human    75 LPASPAPDPP---DPPDSAGP----GPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAV 132

  Fly    67 GVG---VVAGSEGVNLDSSPRESGDDSED-ESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAM 127
            |.|   .:...|.|.|:.  |...::.|| |::.:..||.||:||...|:.:   .....|:..:
Human   133 GPGSREPLRVPEAVALER--RREQEEKEDMETQAVATSPDGRYLKFDIEIGR---GSFKTVYRGL 192

  Fly   128 DTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFIT 192
            ||:..|||.|.|:|...|.  :::.::..:..:.|..|.|.|||:|:..|....:.: ..:|.:|
Human   193 DTDTTVEVAWCELQTRKLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQ-VCIVLVT 254

  Fly   193 EYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQ-HNG 256
            |.|:||:||.:|:|.:....|:    .:||..|||..|.:|||..|||:|.:|.||::||. ..|
Human   255 ELMTSGTLKTYLRRFREMKPRV----LQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTG 315

  Fly   257 LVKIG--------------SVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLTAALDIY 307
            .||||              ||:                    |...|.|||. ..::...|:|:|
Human   316 SVKIGDLGLATLKRASFAKSVI--------------------GTPEFMAPEM-YEEKYDEAVDVY 359

  Fly   308 AFGMCALEMAALEIQPSNSESTAINEETIQRTIFS--LENDLQ-------RDLIRKCLNPQPQDR 363
            |||||.||||..|...|..::.|    .|.|.:.|  ..|...       :::|..|:.....:|
Human   360 AFGMCMLEMATSEYPYSECQNAA----QIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNER 420

  Fly   364 PSANDLLFHPLLFE---VH 379
            .:..|||.|....|   ||
Human   421 FTIQDLLAHAFFREERGVH 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	85/285 (30%)
		S_TKc	123..375	CDD:214567	85/275 (31%)
WNK4	XP_016880451.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840