DRSC/TRiP Functional Genomics Resources

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Protein Alignment Madm and WNK1

DIOPT Version :9

Sequence 1:NP_001303420.1 Gene:Madm / 40710 FlyBaseID:FBgn0027497 Length:637 Species:Drosophila melanogaster
Sequence 2:XP_011519299.1 Gene:WNK1 / 65125 HGNCID:14540 Length:2795 Species:Homo sapiens


Alignment Length:699 Identity:170/699 - (24%)
Similarity:267/699 - (38%) Gaps:220/699 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 STVADEPIQHHPSLA-------AGPVSASCPAAT----PPSQ-----STQQPPPHIVSASTADAG 61
            |.||.:|    |:.|       |||..::.|::|    |.||     |.::|||    |.:...|
Human   131 SQVAQQP----PAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPP----ARSGSGG 187

  Fly    62 SSAAVGVGVVAGSEGVNLDSSPRESGDDSEDESEILEE-----SPCGRWLKRREEVDQRDVPGID 121
            .||                ..|:|.....:|:.|.||.     |..||:||...|:.:   ....
Human   188 GSA----------------KEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGR---GSFK 233

  Fly   122 CVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERP 186
            .|:..:|||..|||.|.|:|...|  .||:.::.::..:.|..|.|.|||:|:..|..|.:.:: 
Human   234 TVYKGLDTETTVEVAWCELQDRKL--TKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKK- 295

  Fly   187 RVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIF 251
            .:|.:||.|:||:||.:|||    .|.:.::..|.||.|||..|.:||:.:|||||.:|.||:||
Human   296 CIVLVTELMTSGTLKTYLKR----FKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIF 356

  Fly   252 IQ-HNGLVKIG--------------SVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLT 301
            |. ..|.||||              ||:                    |...|.|||. ..::..
Human   357 ITGPTGSVKIGDLGLATLKRASFAKSVI--------------------GTPEFMAPEM-YEEKYD 400

  Fly   302 AALDIYAFGMCALEMAALE-------------------IQPSNSESTAINEETIQRTIFSLENDL 347
            .::|:||||||.||||..|                   ::|::.:..||.|              
Human   401 ESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPE-------------- 451

  Fly   348 QRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLMQRYY 412
            .:::|..|:.....:|.|..|||.|....|                       ||.         
Human   452 VKEIIEGCIRQNKDERYSIKDLLNHAFFQE-----------------------ETG--------- 484

  Fly   413 QPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNFRSRAASPERA 477
                  .::.||...:.:      ..|.||...:||:|       ...||...|.....:.....
Human   485 ------VRVELAEEDDGE------KIAIKLWLRIEDIK-------KLKGKYKDNEAIEFSFDLER 530

  Fly   478 DSVKSATPEPVD----------TESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQ----LT 528
            |..:....|.|:          |.::.|.:.:..:|.|.:...     |:|.:.:..:|    |.
Human   531 DVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQ-----LVREEQEKKKQEESSLK 590

  Fly   529 CQVNEND---------------------TAADLTSELVRLGFVHLDDQDKIQVLLEETLKAGVMS 572
            .||.::.                     |:|.:::::.    ....:.|:.|.|..:.....|:|
Human   591 QQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVE----PEEPEADQHQQLQYQQPSISVLS 651

  Fly   573 DGAGAESSGAGVTTTATMAALEQLERNWSISSDADKQGTAVMYVPQEQQ 621
            ||......|:.|.|.:.::: :|.....|....|...||...::|...|
Human   652 DGTVDSGQGSSVFTESRVSS-QQTVSYGSQHEQAHSTGTVPGHIPSTVQ 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MadmNP_001303420.1 PK_NRBP1_like 114..376 CDD:270886 90/295 (31%)
S_TKc 123..375 CDD:214567 90/285 (32%)
WNK1XP_011519299.1 STKc_WNK1 195..483 CDD:270932 102/355 (29%)
S_TKc 226..479 CDD:214567 91/297 (31%)
OSR1_C 500..537 CDD:289010 9/43 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141385
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X143
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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