DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Madm and nrbp2a

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_001920672.2	Gene:	nrbp2a / 564177	ZFINID:	ZDB-GENE-070713-4	Length:	508	Species:	Danio rerio

Alignment Length:	505	Identity:	246/505 - (48%)
Similarity:	352/505 - (69%)	Gaps:	32/505 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 VAGSEGVNLDSSPRESGDDSEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEV 135
            ::||.|         ..::||||||||||||||||.||||:|.|.:||||:..:|||||||||||
Zfish     9 ISGSGG---------KEEESEDESEILEESPCGRWQKRREQVSQGNVPGIESAYLAMDTEEGVEV 64

  Fly   136 VWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSL 200
            ||||||::..:..||.||::|::|:||:|::|.||||||:||.|.::: |.||:|||||||||||
Zfish    65 VWNEVQFSDKKVFKSFEERIREMFENLMQVEHPNIVKFHKYWLDMRES-RARVIFITEYMSSGSL 128

  Fly   201 KQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGS--- 262
            |||||:||:|.|.:.:::|:||||||||||||||||.|||||||||||:||||||||:||||
Zfish   129 KQFLKKTKKNHKTMNVKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVWH 193

  Fly   263 -----VVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQ 322
                 |..:|:|.:|    .:.|:..|..|:| |||||.|:. ..|:||::||:|.||||.||||
Zfish   194 RLFVNVFAEAIHGNV----HQHRDEVRNQHFF-APEYGIAED-NYAIDIFSFGICGLEMAVLEIQ 252

  Fly   323 PSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAH 387
            .:.  .||:.:|.|.....|||:.|.|:.|:.|:..:.:.||:|:|||||.:||||||||||.||
Zfish   253 ANG--DTAVAKEAIDYAGQSLEDPLMREFIQSCVRTEAKSRPTAHDLLFHRVLFEVHSLKLLAAH 315

  Fly   388 CLVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYG 452
            |.:   .|:.:..|...:. ..:.|.|:.:||::..........:.:.||..: |:||:||||.|
Zfish   316 CFI---NNQYLLPENCVEE-KTKSYDPNGIMAEINHRNRPGVHLKYSHVSPLE-LDKFLEDVKNG 375

  Fly   453 VYPLITYSGKKP-PNFRSRAASPERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSNDITMTIL 516
            :|||:.::.::| |..|:.:.|.|:.::||:.||||.:||:|::|.:.|:::..|:.....:::.
Zfish   376 IYPLMNFASQRPHPIPRALSLSQEQMETVKTPTPEPQETETRKVVQIHCNLEATEEGTRSHLSLF 440

  Fly   517 LRMDDKMNRQLTCQVNENDTAADLTSELVRLGFVHLDDQDKIQVLLEETL 566
            |:|||:::|||:|.|..:|:..||.||||...|:..:|.:|:...||:.|
Zfish   441 LKMDDRLHRQLSCDVLPSDSPKDLASELVHHAFISEEDCEKLACFLEDAL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	151/269 (56%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	146/259 (56%)
nrbp2a	XP_001920672.2	PKc_like	43..304	CDD:304357	151/269 (56%)
nrbp2a	XP_001920672.2	S_TKc	53..300	CDD:214567	144/255 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574305
Domainoid	1	1.000	282	1.000	Domainoid score	I1616
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1416
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233882at33208
OrthoFinder	1	1.000	-	-		FOG0002915
OrthoInspector	1	1.000	-	-		otm25350
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3170
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.030