DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and Wnk

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001262171.2	Gene:	Wnk / 40391	FlyBaseID:	FBgn0037098	Length:	2462	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	138/543 - (25%)
Similarity:	226/543 - (41%)	Gaps:	120/543 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VSASTADAGSSAAVGVGVVAGSEGVNLDSSPRESGDDSEDESEILEESPCGRWLKRREEVDQRDV 117
            |:.|:.||.:|......:|:.:...   :|..:|..|.:|:...:  |||||:.|..:||.:
  Fly   423 VTGSSTDASASPLPSTSLVSTTSSA---TSITKSKSDEDDDPVAM--SPCGRFFKYDKEVGR--- 479

  Fly   118 PGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQ 182
            .....|:..:||..||.|.|.|:  ...|..||:..:.|:..|.|.:|.|.|||:|:.|| :...
  Fly   480 GSFKTVYRGLDTLTGVPVAWCEL--LDKQVKKSERTRFREEADMLKKLQHPNIVRFYTYW-EFPI 541

  Fly   183 AERPRVVFITEYMSSGSLKQFLKRTKR-NAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLT 246
            ..:..:|.:||.|.||:||.:|||.|: :.|.|     :.||.|||..|::||:...||||.:|.
  Fly   542 GRKKNIVLVTELMLSGTLKSYLKRFKKIHPKVL-----KSWCRQILKGLNFLHTRQFPIIHRDLK 601

  Fly   247 CDSIFIQ-HNGLVKIGSVVPDAVHYSVRRGRERERERERGAHYFQAPEYGA----ADQLTAALDI 306
            ||:|||. ..|.||||.:           |....:.|.........||:.|    .:....::|:
  Fly   602 CDNIFITGTTGSVKIGDL-----------GLATLKNRSHAKSVIGTPEFMAPEMYEEHYDESVDV 655

  Fly   307 YAFGMCALEMAALEIQPSNSESTA-INEETIQ----RTIFSLENDLQRDLIRKCLNPQPQDRPSA 366
            ||||||.||||..|...|..:..| |.::.|.    ..:..:|:...||:|.:|:..:.:||||.
  Fly   656 YAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSC 720

  Fly   367 NDLL------------FHPLLFEVH----SLKLLTAHCLVFSPANRTM-------------FSET 402
            |:||            ..|...|..    |:.::........|..|:.             ....
  Fly   721 NELLESEFFDEDIGIRVEPTASEQFLSDPSISIIEFRLRFMDPKKRSSRHKENEAIQFEYNIRHD 785

  Fly   403 AFDGLMQRYYQPDVV--------------------------MAQLRLAGGQERQYRLA------- 434
            .::.:.|...:.:::                          ..|::|...:.|..:||
  Fly   786 EYEQIAQEMMKENIISEDDSRAVARLLKVQVVSLLKERAQRQTQIKLQNEKSRLEKLALQKQRES 850

  Fly   435 ---DVSGADKLEKFVEDVKYGV---------YPLITYSGKKPPNFRSRAASPERADSVKSAT--- 484
               :|...::.|:..||.:.||         |.|:....:......:.:..|::. |.:|.|
  Fly   851 LPTNVDEDEEEEEESEDEEDGVKWNQRLQLRYDLLNTDSETSLALSTNSVEPQQL-STRSNTSIP 914

  Fly   485 ----PEPVDTESRRIVNMMCSVK 503
                .:||....:..|:.:.||:
  Fly   915 NSGIQQPVQVPGQVPVSQLISVQ 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	93/284 (33%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	93/274 (34%)
Wnk	NP_001262171.2	STKc_WNK	469..729	CDD:270885	96/281 (34%)
		S_TKc	471..729	CDD:214567	95/279 (34%)
		OSR1_C	754..791	CDD:289010	2/36 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233882at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13902
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950