DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and dstyk

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_005168327.1	Gene:	dstyk / 402922	ZFINID:	ZDB-GENE-040826-2	Length:	885	Species:	Danio rerio

Alignment Length:	682	Identity:	125/682 - (18%)
Similarity:	229/682 - (33%)	Gaps:	244/682 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 CGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLD 166
            ||||    :.|.::|:...:|...|....| :|:.   :.:..|||:|            ::.|.
Zfish   150 CGRW----DTVPRQDLEIQECEDPAQRLAE-LEIT---LHHTLLQEVK------------IMVLP 194

  Fly   167 HQNIVKFHRYWTDTQQAERPRVVFIT--EYMSSGSLKQFLKRTKRNAKRLPLESWRRWC------ 223
            .:|:........|.::...|.|::..  |.:|:..|:..  :|.|.:...|:      |
Zfish   195 CRNVQPLEEALEDCKRGILPIVLYAVSRESLSAQQLEDL--QTLRESLPFPV------CFIRVSD 251

  Fly   224 -------------TQILSALSYLHSCSPPIIHG-----NLTCDSI------------FIQHNGLV 258
                         .|::||.:...:|..|....     .:.|||:            .:..|..|
Zfish   252 GGGGGALFTQLASLQLISASAGNCACGAPAAQSAGRMQGVLCDSLERLQRVLVPFTRQVLQNQQV 316

  Fly   259 KIGSVVPDAVH-----------YSVRRG-----RERERERERGAHYFQAPEYGAADQLTAALDIY 307
            :..::: :.:|           :.::|.     |..|..||:....|.:....|..:.....::.
Zfish   317 EAATLL-NTIHCRCLDLFIIQAFDMQRDLQITPRRLEYTREKEGELFCSLMAIANRKQEEMKEMI 380

  Fly   308 AFGMCALEMAALE----------IQPSNSESTA----------INEETIQRTIFSLENDLQRDL- 351
            ...:.:::...||          |..||.|..:          |.:..:.|...::.|.|...:
Zfish   381 VETLSSMKEQLLEDAQNLDFTDIIMSSNGEPVSSKDIKVCISQIQDLIVNRLNQAVANKLTNSVD 445

  Fly   352 ---------IRKCLNPQPQDRP-------SAN------------DLLFHP------LLFE----- 377
                     :.:||....:..|       ::|            ::.||.      |.:|
Zfish   446 YLRESFVGTLERCLGSLEKSTPESCAHNVTSNHLKQILNAAYHVEVTFHSGSSVTRLFWEQIKQI 510

  Fly   378 VHSL---------------------------KLLTAHCLVFSPANRTMFSETAF--------DGL 407
            :|.:                           ||..:.|..|  ..|...|..||        :|.
Zfish   511 IHRITWVNPPAITAEWKRKVAQDAIESLSAAKLAKSICSQF--RTRLNSSHEAFAASLRQLEEGH 573

  Fly   408 MQRYYQPDVVMAQLRLAGGQERQYRLADVS------------GADKLEKFVEDVKYG-VYPLITY 459
            ..|..:.:.:..::|    ::...|||.:|            |..||.:.:...:|| ||...::
Zfish   574 TGRLERTEDLWLRVR----KDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVYLCDSW 634

  Fly   460 SGKKPPNFRSRAASPERADSVKSATPEPVD------------TES----RRIVNMMCSVKIKEDS 508
            :|:.|             .::||..| |.|            |.|    .|:||:..||.....|
Zfish   635 AGRHP-------------CALKSVVP-PDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYS 685

  Fly   509 NDITMTILLRMDDKMNRQLTCQVNENDT-------AADLTSELVRL----GFVHLDDQDKIQVLL 562
            ...::.:||.| ::::|.|...:....:       |.|:. |.:|.    |.:|.|.:.| .|||
Zfish   686 GGSSIAVLLIM-ERLHRDLYTGLKAGLSLKERLLIALDVV-EGIRFLHSQGLLHRDIKLK-NVLL 747

  Fly   563 EETLKAGVMSDG---AGAESSGAGVTTTATMA 591
            ::..:|.:...|   ..|..||:.|.|...||
Zfish   748 DKQNRAKITDLGFCKPEAMMSGSIVGTPIHMA 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	56/370 (15%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	53/360 (15%)
dstyk	XP_005168327.1	PKc_Dusty	613..874	CDD:270877	46/184 (25%)
dstyk	XP_005168327.1	S_TKc	615..859	CDD:214567	46/182 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930