Protein Alignment Madm and Wnk3

DIOPT Version :9

• Sequence 1: NP_001303420.1
• Gene: Madm / 40710
• FlyBaseID: FBgn0027497
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: XP_006256844.1
• Gene: Wnk3 / 317420
• RGDID: 1563131
• Length: 1745
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 155/642 - (24%)
• Similarity: 237/642 - (36%)
• Gaps: 220/642 - (34%)

  Fly    66 VGVGVVAGSEGVNLDSSPRESGDDSED------ESEILEE--------SPCGRWLKRREEVDQRD 116
            |...|:.|.:.|..:...:.:.:.|:|      |.|:.||        ||.||:||...|:.:
  Rat    92 VPTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGR-- 154

  Fly   117 VPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQ 181
             .....|:..:|||..|||.|.|:|...|  .|:::::.::..:.|..|.|.|||:|:..|....
  Rat   155 -GAFKTVYKGLDTETWVEVAWCELQDRKL--TKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL 216

  Fly   182 QAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLT 246
            :.:: .:|.:||.|:||:||.:|||.|....::    .|.||.|||..|.:||:.:|||||.:|.
  Rat   217 KGKK-CIVLVTELMTSGTLKTYLKRFKVMKPKV----LRSWCRQILKGLQFLHTRTPPIIHRDLK 276

  Fly   247 CDSIFIQ-HNGLVKIG--------------SVVPDAVHYSVRRGRERERERERGAHYFQAPEYGA 296
            ||:|||. ..|.||||              ||:                    |...|.|||. .
  Rat   277 CDNIFITGPTGSVKIGDLGLATLMRTSFAKSVI--------------------GTPEFMAPEM-Y 320

  Fly   297 ADQLTAALDIYAFGMCALEMAALEIQPSNSESTAINEETIQRTI--------FSLENDLQ-RDLI 352
            .:....::|:||||||.||||..|...|..::.|    .|.|.:        |:...|.: :::|
  Rat   321 EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAA----QIYRKVTSGIKPASFNKVTDPEVKEII 381

  Fly   353 RKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLMQRYYQPDVV 417
            ..|:.....:|.|..|||                        |...|:|..  ||.....:.|
  Rat   382 EGCIRQNKSERLSIKDLL------------------------NHAFFAEDT--GLRVELAEED-- 418

  Fly   418 MAQLRLAGGQERQYRLADVSGAD-KLEKFVEDVKYGVYPLITYSGKKPPNFRSRAASPERADSVK 481
                             |.|.:. .|..:|||.|
  Rat   419 -----------------DCSNSSLALRLWVEDPK------------------------------- 435

  Fly   482 SATPEPVDTESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQLTCQVN-ENDTAADLTSELV 545
                                 |:|....|             |..:....| |.||..::..|:|
  Rat   436 ---------------------KLKGKHKD-------------NEAIEFSFNLEADTPEEVAYEMV 466

  Fly   546 RLGFVHLDD--------QDKIQVL--LEETLKAGVMSDGAGAESSGAGVTT----TATM------ 590
            :.||.|..|        :|::.::  :.|...||.:.:...::...|....    |||:
  Rat   467 KSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDSQCKHARNVNPQQQTATLRPAPGP 531

  Fly   591 ---AALEQLERNWSISSDADKQGTAVMYVPQEQQNADGDVDVE-------HSGTTSN 637
               |..|:.|.:..:.... .||.|    .|:..:..||...|       ||.|:|:
  Rat   532 HNAAECEETEVDQHVRQQL-VQGKA----QQQPSSVRGDTSSEPAAGPVLHSDTSSH 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	89/285 (31%)
		S_TKc	123..375	CDD:214567	89/275 (32%)
Wnk3	XP_006256844.1	STKc_WNK3	135..409	CDD:270933	99/334 (30%)
		OSR1_C	425..488	CDD:403428	20/127 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840