DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Madm and DSTYK

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_056190.1	Gene:	DSTYK / 25778	HGNCID:	29043	Length:	929	Species:	Homo sapiens

Alignment Length:	193	Identity:	36/193 - (18%)
Similarity:	67/193 - (34%)	Gaps:	66/193 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKI-------------GSVVP 265
            |.||:..:....::..:.:||  |..::|.::...::.:......||             ||:|.
Human   749 LTLETRLQIALDVVEGIRFLH--SQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVG 811

  Fly   266 DAVHYSVRRGRERERERERGAHYFQAPEY--GAADQLTAALDIYAFGMCALEMAALEIQ-PSNSE 327
            ..:|                    .|||.  |..|.   ::|:||||:....:.:..:: |...|
Human   812 TPIH--------------------MAPELFTGKYDN---SVDVYAFGILFWYICSGSVKLPEAFE 853

  Fly   328 STAINEETIQRTIFSLENDLQR---------------DLIRKCLNPQPQDRPSANDLLFHPLL 375
            ..|..:.        |.|:::|               .|:..|.:..|..||...  :..|:|
Human   854 RCASKDH--------LWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG--IVQPML 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	36/193 (19%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	35/191 (18%)
DSTYK	NP_056190.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PKc_Dusty	651..912	CDD:270877	36/193 (19%)
		S_TKc	653..897	CDD:214567	32/180 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930