DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and Wnk1

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_036021959.1	Gene:	Wnk1 / 232341	MGIID:	2442092	Length:	2929	Species:	Mus musculus

Alignment Length:	695	Identity:	167/695 - (24%)
Similarity:	265/695 - (38%)	Gaps:	223/695 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 STVADEPIQHHPSLAAGP--------VSASCPAAT----PPSQ-----STQQPPPHIVSASTADA 60
            :|||.: :...||.||.|        .:.:.|::|    |.||     |.::|||     |.:.:
Mouse   125 ATVASQ-VSQQPSAAASPGEQAVVGSATTTVPSSTSKDRPVSQPSLVGSKEEPPP-----SRSGS 183

  Fly    61 GSSAAVGVGVVAGSEGVNLDSSPRESGDDSEDESEILEE--------SPCGRWLKRREEVDQRDV 117
            ||..|                |.:|:.:|...:.:.:||        |..||:||...|:.:
Mouse   184 GSGGA----------------SAKEAQEDRSQQQDDIEELETKAVGMSNDGRFLKFDIEIGR--- 229

  Fly   118 PGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQ 182
            .....|:..:|||..|||.|.|:|...|  .||:.::.::..:.|..|.|.|||:|:..|..|.:
Mouse   230 GSFKTVYKGLDTETTVEVAWCELQDRKL--TKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVK 292

  Fly   183 AERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTC 247
            .:: .:|.:||.|:||:||.:|||    .|.:.::..|.||.|||..|.:||:.:|||||.:|.|
Mouse   293 GKK-CIVLVTELMTSGTLKTYLKR----FKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKC 352

  Fly   248 DSIFIQ-HNGLVKIG--------------SVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAA 297
            |:|||. ..|.||||              ||:                    |...|.|||. ..
Mouse   353 DNIFITGPTGSVKIGDLGLATLKRASFAKSVI--------------------GTPEFMAPEM-YE 396

  Fly   298 DQLTAALDIYAFGMCALEMAALE-------------------IQPSNSESTAINEETIQRTIFSL 343
            ::...::|:||||||.||||..|                   ::|::.:..||.|
Mouse   397 EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPE---------- 451

  Fly   344 ENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLM 408
                .:::|..|:.....:|.|..|||.|....|                       ||.
Mouse   452 ----VKEIIEGCIRQNKDERYSIKDLLNHAFFQE-----------------------ETG----- 484

  Fly   409 QRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNFRSRAAS 473
                      .::.||...:.:      ..|.||...:||:|       ...||...|.....:.
Mouse   485 ----------VRVELAEEDDGE------KIAIKLWLRIEDIK-------KLKGKYKDNEAIEFSF 526

  Fly   474 PERADSVKSATPEPVD----------TESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQLT 528
            ....|..:....|.|:          |.::.|.:.:..:|.|.:...     |:|.:.:..:|..
Mouse   527 DLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQ-----LVREEQEKRKQEE 586

  Fly   529 C---QVNEND-----------------------TAADLTSELVRLGFVHLDDQDKIQVLLEETLK 567
            .   |.||..                       |:|.:::::.    ....:.|:.|.|..:...
Mouse   587 SSFKQQNEQQASVSQAGIQQLSAASTGIPTAPATSASVSTQVE----PEEPEADQHQQLQYQQPS 647

  Fly   568 AGVMSDGAGAESSGAGVTTTATMAALEQLERNWSISSDADKQGTA 612
            ..|:|||......|:.|.|.:.::: :|.....|....|...|||
Mouse   648 ISVLSDGTIDSGQGSSVFTESRVSS-QQTVSYGSQHEQAHSTGTA 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	90/295 (31%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	90/285 (32%)
Wnk1	XP_036021959.1	STKc_WNK1	195..483	CDD:270932	100/355 (28%)
		OSR1_C	500..563	CDD:403428	13/69 (19%)
		Atrophin-1	1152..>1564	CDD:397323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840