Protein Alignment Madm and hpo-11

DIOPT Version :10

• Sequence 1: NP_649581.1
• Gene: Madm / 40710
• FlyBaseID: FBgn0027497
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_492022.3
• Gene: hpo-11 / 186807
• WormBaseID: WBGene00010427
• Length: 649
• Species: Caenorhabditis elegans
• Alignment Length: 642
• Identity: 239/642 - (37%)
• Similarity: 342/642 - (53%)
• Gaps: 142/642 - (22%)

  Fly    70 VVAGSEGVNLDSSPRESGDDSEDES------EILEESPCGRWLKRREEVDQRDVPGIDCVHLAMD 128
            |.:|.|......:|  .|||:..:|      |||||||..||.||||:|.||||||||..:||||
 Worm     2 VSSGEERTAAGKTP--IGDDAASDSDADGAEEILEESPDKRWSKRREQVKQRDVPGIDVAYLAMD 64

  Fly   129 TEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITE 193
            .|.|.||||||||::..:..::||||:..|||||.||.|.|:||||:||||: ::|:||::||||
 Worm    65 NETGNEVVWNEVQFSERKNFRAQEEKINAVFDNLTQLVHTNLVKFHKYWTDS-KSEKPRIIFITE 128

  Fly   194 YMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLV 258
            ||||||:..||:||::....|.:::|::|.|||||||:||||..||||||||||:::|||.|||:
 Worm   129 YMSSGSMSAFLQRTRKAGSSLSIKAWKKWTTQILSALNYLHSSDPPIIHGNLTCNTVFIQQNGLI 193

  Fly   259 KIGSVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAAD--QLTAALDIYAFGMCALEMAAL-- 319
            |||.|.|||:::.|:..||..|.    .||. ||||...|  :||:|.|||:||:|:||:|.:
 Worm   194 KIGCVAPDAINHHVKTCRENMRY----MHYI-APEYEILDNTELTSAADIYSFGICSLEIAVIGG 253

  Fly   320 --EIQPSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLK 382
              ..|..:||. .:.|:.|::.|.|||:.:|:|.||:||...|.:||||.:||||.:||||||||
 Worm   254 LSGCQNGSSEG-PVTEDVIEKAIRSLEDPMQQDFIRQCLRKDPAERPSARELLFHQILFEVHSLK 317

  Fly   383 LLTAHCLVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVE 447
            ||:||.:|.|.....: ||:||     |....:.:.|..:|   :|..|........| ||||::
 Worm   318 LLSAHAIVDSKKYEDV-SESAF-----RIKDNETIAATSKL---REMAYCQVAAFQVD-LEKFLD 372

  Fly   448 DVKYGVYPLI--------------TYSGKKP---------------------------------- 464
            ||:.|:|||.              .||...|
 Worm   373 DVRNGIYPLTAFAPLAHQPSTTLRAYSNTNPSTLITTDISAPSSTHPSANSTITAETSVNTSLPG 437

  Fly   465 --------------PNFRSRAASPERAD--------------------------------SVKSA 483
                          |:...::||||..|                                ...|.
 Worm   438 QSSQPSGTTTNTNGPSSIGKSASPEAVDKKIGEVTSTESTSKVEVEVNGANVTIGSSNGRDAGSP 502

  Fly   484 TPE---------PVDTESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQLTCQVNENDTAAD 539
            |||         .:..|:|.|:.:...::.:|      |:|:|.::|:|:||||..:|:.|....
 Worm   503 TPEEEGEPNGERDMRLENRHILEINVHIENEE------MSIVLLLEDQMHRQLTTSINKGDNPET 561

  Fly   540 LTSELVRLGFVHLDDQDKIQ--VLLEETLKAGVMSDGAGAESSGAGVTTTATMAALE 594
            ||..|:..||:...|.:.::  :.:...::|..:::|...|.:......:.:.|.:|
 Worm   562 LTENLITHGFMCQLDSEGVEKAIAVAFDIRAARIAEGVQEEENETSTRESNSEAPIE 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_649581.1	PK_NRBP1_like	114..376	CDD:270886	144/267 (54%)
hpo-11	NP_492022.3	Protein Kinases, catalytic domain	50..311	CDD:473864	144/267 (54%)
		PHA03255	376..>490	CDD:165513	13/113 (12%)