DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Madm and wnk1a

DIOPT Version :9

Sequence 1:	NP_001303420.1	Gene:	Madm / 40710	FlyBaseID:	FBgn0027497	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_021326361.1	Gene:	wnk1a / 100318736	ZFINID:	ZDB-GENE-080917-49	Length:	1634	Species:	Danio rerio

Alignment Length:	448	Identity:	127/448 - (28%)
Similarity:	190/448 - (42%)	Gaps:	121/448 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNSQA------NAGISGSTVADEPIQHHPSL---AAGPVSASCP---AATPPSQSTQQPPPHIVS 54
            ||:.|      ||.::.||.:..|:...|:|   ||..::.|.|   .|.......:..|..|.:
Zfish    64 SNATALELPSKNAILTHSTDSHAPVCEPPALETKAASVITQSAPEKKVADVVEMVIESTPVLITN 128

  Fly    55 AS---TADAGSSAAVGVGVVAGSEGVN-----------------------LDSSPRESGDDSEDE 93
            |:   :|:|.|.    |..|...:|::                       |..:.:|..|:.|.|
Zfish   129 AALHLSAEAPSL----VSEVKSGDGIDGKREAEKEEDEDSKEKAARAEAELRDAKKEEEDNEEIE 189

  Fly    94 SEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQV 158
            :..:..||.||:||...|:.:   .....|:..:|||..|||.|.|:|...|.  ||:.::.::.
Zfish   190 TNAVGTSPDGRFLKFDIEIGR---GSFKTVYKGLDTETTVEVAWCELQDRKLS--KSERQRFKEE 249

  Fly   159 FDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWC 223
            ...|..|.|.|||:|:..|..:.:. |..:|.:||.|:||:||.:|||    .|.:.::..|.||
Zfish   250 AGMLKGLQHPNIVRFYDSWESSLKG-RKCIVLVTELMTSGTLKTYLKR----FKEMKIKVLRSWC 309

  Fly   224 TQILSALSYLHSCSPPIIHGNLTCDSIFIQ-HNGLVKIG--------------SVVPDAVHYSVR 273
            .|||..|.:||:.||||||.:|.||:|||. ..|.||||              ||:
Zfish   310 RQILKGLHFLHTRSPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVI--------- 365

  Fly   274 RGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALE------------------ 320
                       |...|.|||. ..::...::|:||||||.||||..|
Zfish   366 -----------GTPEFMAPEM-YEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTS 418

  Fly   321 -IQPSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFE 377
             ::|.:.:..||.|              .:::|..|:.....:|....|||.|....|
Zfish   419 GVKPGSFDKVAIPE--------------VKEIIEGCIRQNKDERYCIKDLLSHAFFQE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_001303420.1	PK_NRBP1_like	114..376	CDD:270886	90/295 (31%)
Madm	NP_001303420.1	S_TKc	123..375	CDD:214567	90/285 (32%)
wnk1a	XP_021326361.1	STKc_WNK1	179..464	CDD:270932	102/329 (31%)
wnk1a	XP_021326361.1	OSR1_C	481..518	CDD:314980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X143
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840