Protein Alignment Madm and wnk1a

DIOPT Version :10

• Sequence 1: NP_649581.1
• Gene: Madm / 40710
• FlyBaseID: FBgn0027497
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: XP_009296302.2
• Gene: wnk1a / 100318736
• ZFINID: ZDB-GENE-080917-49
• Length: 1633
• Species: Danio rerio
• Alignment Length: 722
• Identity: 172/722 - (23%)
• Similarity: 269/722 - (37%)
• Gaps: 205/722 - (28%)

  Fly     2 SNSQA------NAGISGSTVADEPIQHHPSL---AAGPVSASCP---AATPPSQSTQQPPPHIVS 54
            ||:.|      ||.::.||.:..|:...|:|   ||..::.|.|   .|.......:..|..|.:
Zfish    64 SNATALELPSKNAILTHSTDSHAPVCEPPALETKAASVITQSAPEKKVADVVEMVIESTPVLITN 128

  Fly    55 AS---TADAGSSAAVGVGVVAGSEGVN-----------------------LDSSPRESGDDSEDE 93
            |:   :|:|.|.    |..|...:.::                       |..:.:|..|:.|.|
Zfish   129 AALHLSAEAPSL----VSEVKSGDSIDGKREVEKEEDEDSKEKAARAEAELRDAKKEEEDNEEIE 189

  Fly    94 SEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQV 158
            :..:..||.||:||...|:.:   .....|:..:|||..|||.|.|:|...|.  ||:.::.::.
Zfish   190 TNAVGTSPDGRFLKFDIEIGR---GSFKTVYKGLDTETTVEVAWCELQDRKLS--KSERQRFKEE 249

  Fly   159 FDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWC 223
            ...|..|.|.|||:|:..|..:.:. |..:|.:||.|:||:||.:|||    .|.:.::..|.||
Zfish   250 AGMLKGLQHPNIVRFYDSWESSLKG-RKCIVLVTELMTSGTLKTYLKR----FKEMKIKVLRSWC 309

  Fly   224 TQILSALSYLHSCSPPIIHGNLTCDSIFIQ-HNGLVKIG--------------SVVPDAVHYSVR 273
            .|||..|.:||:.||||||.:|.||:|||. ..|.||||              ||:
Zfish   310 RQILKGLHFLHTRSPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVI--------- 365

  Fly   274 RGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALE------------------ 320
                       |...|.|||. ..::...::|:||||||.||||..|
Zfish   366 -----------GTPEFMAPEM-YEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTS 418

  Fly   321 -IQPSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLL 384
             ::|.:.:..||.|              .:::|..|:.....:|....|||.|....|
Zfish   419 GVKPGSFDKVAIPE--------------VKEIIEGCIRQNKDERYCIKDLLSHAFFQE------- 462

  Fly   385 TAHCLVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDV 449
                            ||.                 :|:...:|....|.    |.||...:|||
Zfish   463 ----------------ETG-----------------VRVELAEEDDGELV----AIKLLLRIEDV 490

  Fly   450 KYGVYPLITYSGKKPPNFRSRAASPERADSVKSATPEPVD----------TESRRIVNMMCSVKI 504
            |       ...||...|.....:.....|:......|.|:          |.::.|.:.:..:..
Zfish   491 K-------KLKGKYKENEAIEFSFDLDKDNPDDVAQEMVESGYICEGDHKTIAKAIKDRVSLISR 548

  Fly   505 KEDSNDITMTILLRMDDKMNRQLTCQVNENDTAADLTSELVRLGFVHLDDQDKIQVLLEETLKAG 569
            |.:...:.      .:::..|::.   .||| ||..|:..|:.....|     ..|::|......
Zfish   549 KREQRKLV------REEQEKRKME---QEND-AAQQTNPTVKSPGSAL-----ASVIMESEEAET 598

  Fly   570 VMSDGAGAESSGAGVT---TTATMAALEQLERNWSISS---DADKQGTAVMYVPQEQQNADGDVD 628
            ......||.:|..|..   ::.|:.....::.|.|.|:   |...|.|.:.  ||..........
Zfish   599 DQHQQPGASASAVGFVDPQSSVTILEAHPVQPNTSFSTTQPDPQPQHTIIR--PQSMSQHPVQAP 661

  Fly   629 VEHSGTT 635
            ::...:|
Zfish   662 LQQPSST 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Madm	NP_649581.1	PK_NRBP1_like	114..376	CDD:270886	90/295 (31%)
wnk1a	XP_009296302.2	STKc_WNK1	179..464	CDD:270932	102/352 (29%)
		OSR1_C	481..544	CDD:463491	14/69 (20%)
		PAT1	<571..>738	CDD:401645	21/105 (20%)
		PHA03307	920..>1347	CDD:223039