DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sym and AT1G27595

DIOPT Version :9

Sequence 1:	NP_649580.1	Gene:	Sym / 40709	FlyBaseID:	FBgn0037371	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_001319093.1	Gene:	AT1G27595 / 839651	AraportID:	AT1G27595	Length:	1325	Species:	Arabidopsis thaliana

Alignment Length:	1361	Identity:	309/1361 - (22%)
Similarity:	526/1361 - (38%)	Gaps:	354/1361 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ATARAKVVDWCNELVIASP-----STKCELLAKVQETVLGSCAELAEEFLESVLSLAHDSNMEVR 83
            |||||:.:    .|:.|:.     :.|...|.:|:|.:|.....|:.|....:..|.....:.||
plant     7 ATARAQAL----SLLAAANNHGDLAVKLSSLRQVKEILLSLEPSLSAEIFPYLAELHLSREILVR 67

  Fly    84 KQVVAFVEQVCKVKVELLPHVINVVSMLL---RDNSAQVIKRVIQACGSIYKNGLQYLCSLMEPG 145
            |.::..:|:   |.:.:|.|...:||:||   ||....|.|:.|..       |..:.|:::|
plant    68 KSLIEIIEE---VGLRMLDHSYVLVSVLLVLSRDEDPTVAKKSISV-------GTTFFCTILE-- 120

  Fly   146 DSAEQ-------------AWNILSLIKAQIL-DMIDNENDGIRTNAIKFLEGVVVL--QSFADED 194
            :.|.|             .|..:...|..:. ..::....|::..|:||:|..::|  ...:|.:
plant   121 EMAMQFHHRGKVDRWCGELWTWMVKFKDTVFATALEPGCVGVKVLALKFMETFILLFTPDASDPE 185

  Fly   195 SLKRDGD---FSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISSVN------LIACTSS 250
            ....:|.   |:::.:.....:.....|..|.|....||:.|     |.|.|      .|:..|.
plant   186 KASSEGSRHMFNISWLAGGHPILNPATLMSEANRTFGILVDF-----IQSANRLPGALTISVISC 245

  Fly   251 LCTIAKMRPIFMGAVVEAFKQLNANLPPTLTDSQVSSVRKS--------LKMQLQTLLKNRGAFE 307
            |..:|:.||:....|:....:.:.|| .|:.....:||:.|        |:.....::::|.  :
plant   246 LAVVARKRPVHYNTVLSVLLEFHPNL-ETVKGCHAASVQYSIRTAFLGFLRCTFSPIIESRD--K 307

  Fly   308 FASTIRGMLVDLGSSTNEIQKLIPKMDK----QEMARRQ--------------------KRIL-- 346
            .....|.|     ::.:...:::.::||    .|.|.|:                    |||:
plant   308 LLRAFRAM-----NAADVADQVLRQVDKLVRNNERAARENWSGKNNQVISHQNSWDLSKKRIMPQ 367

  Fly   347 --------ENAAQSLAKRARLACEQQDQQQREME-------------LDTEELERQKQKSTRVNE 390
                    |.|.:.:.....:...||.|....::             |...||...:|..:.:.
plant   368 GEDDTINGEVAPKRVRHNTNMHLTQQVQTNESLQGPVSINGISSGNHLSDSELTPVEQMVSMIG- 431

  Fly   391 KFLAEHFR------------NPETVVTLVLEFLPSLPTEVPQKFLQEYTPIREMSIQQQVTNISR 443
            ..|||..|            :|:.:..:|:..:..||:..|.......||...:......|..|.
plant   432 ALLAEGDRGAASLEILISKLHPDMLADIVITSMKHLPSTPPTLASSVATPADIVVSSSTNTVHSP 496

  Fly   444 FFGEQLSEKRLGPGAATFSREP---------------------PMRVKK---------------- 471
            ....||....:.|..::||..|                     |.|:..
plant   497 TPPAQLPFDPILPAGSSFSEVPSLSSSVADPRRDPRRDPRRMDPRRLNSSVGPTSLPVGEGKESV 561

  Fly   472 -VQAIESTL--------------------TAMEVD-------------------EDAVQKLSEEE 496
             ||...|||                    ||:|:.                   ||.:...:|..
plant   562 PVQKDISTLLSKPVSVSAVTPGATGSVHSTAVELSQNKMMGSSGIRIIDPPECREDLLTVPNECS 626

  Fly   497 FQRKEEAT-----------KKLRETM--------------------------------------- 511
            :..||.::           :.:|||.
plant   627 YPSKEISSLDVPLSPCRDDEGIRETKYSVPDLDMLSVPDFDQHSPSASVPDFDQDPPAASDITAP 691

  Fly   512 ERAKGE----QTVIEKMKERAKTL-KLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKGGVSSK 571
            |.:..|    .:.:|...|::||: ||                  |:.||:.|.|.......:..
plant   692 EESYRELDPVPSYVELTTEQSKTVGKL------------------AIERIIESNRHVFGFDCNKI 738

  Fly   572 RRKLVTVIAATFP--DNVRYGIMEFILEDIKQ--RIDLAFSWLFEEYSLLQGFTRHTYVKTENRP 632
            |..|:..:.|...  .:|...:.|.|..|.::  ..||....|:..:|:       ..:.|:...
plant   739 RMALIARLIARIDAGSDVATILRELISVDHREFKGHDLVLHVLYHLHSM-------AILDTDESS 796

  Fly   633 DHA--YNELLNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLS-----------LD 684
            .:|  |...|..:.....:.....||  ...|::.|||.||:.:|..|.:|.           .|
plant   797 FYATVYENFLISVARSFLDALPASDK--SFSRLFGEAPHLPDSAINLLDELCSTRHDPVGKEVCD 859

  Fly   685 DEFSQHGLELIKDLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVS--LYHVHKILPARID 747
            .|....||..:..|.::||..:...:.:.|..|||...::|..| ..||:  |||: ..:...::
plant   860 SERVTQGLGAVWSLILVRPNERKACLAIALKCSVHSEEEVRAKA-IRLVTNKLYHL-TYIAEHVE 922

  Fly   748 EFALEWL-----------------KFIEQES-PPAAVFSQDFGRPTEEPDWRED----------- 783
            :||.:.|                 :.|:.|: ....:.::..|....:...::|
plant   923 QFATDMLLTAVNSETNLSQTASTAEGIKMEAKSQITLTTESLGSGNSDIPSQQDLQTSREVSVIS 987

  Fly   784 --TTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRSLDIPIKKMGVESPTLLQLIED 846
              ..:....|.|.|...||.: |:.:.:|:......:.:...|.:.|.|:::|.....|||:|.|
plant   988 ISEAQRLISLFFALCKKKPSL-LRLVFEVYGRAPKMVNQAFHRHIPILIRELGSSYTELLQIISD 1051

  Fly   847 CPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRVMIPVLSGLTRSELISVLPKLI 911
            .|||.|.|:..::.|||:.: :|..:|:..|:.||:.|:|||.::||:||.||:.|::.:.|.|:
plant  1052 PPKGSENLLTYVLQILTQEL-APSLDLIATVKHLYETKLKDVSILIPLLSSLTKDEVLPIFPPLL 1115

  Fly   912 KLNPAVVKEVFNRLLG-IGAEFAHQTMAMTPTDILVALHTI--DTSVCDIKAIVKATSLCLAERD 973
            .|.|    |.|...|. |....||...|:||.::|:|:|.|  :.....:|.|..|.|.|..:|.
plant  1116 NLPP----EKFQLALAHILQGSAHTGPALTPAEVLIAIHDIVPEKDGPPLKKITDACSACFEQRT 1176

  Fly   974 LYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLLQRLIIKQVWRQKVIWEGFL 1038
            ::||:||...|.|:|:.||||.|.|||.||::..:|.|.:|||.:|.:|:.||:||...:|.|||
plant  1177 VFTQQVLAKALGQMVDRTPLPLLFMRTVIQAIDAFPTLVDFVMEILSKLVRKQIWRLPKLWPGFL 1241

  Fly  1039 KTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDEPMNGSGITQQVLDII 1099
            |.|.:.||.|.|:||.||..||...:::.|||||:|:.||    ::|...|.:....|.::
plant  1242 KCVSQTKPHSFPVLLELPVPQLESIMKKFPDLRPSLTAYA----NQPTIRSSLPNSALSVL 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sym	NP_649580.1	DUF3453	115..345	CDD:288763	51/286 (18%)
Sym	NP_649580.1	Symplekin_C	887..1067	CDD:289095	76/182 (42%)
AT1G27595	NP_001319093.1	DUF3453	100..314	CDD:403220	43/230 (19%)
AT1G27595	NP_001319093.1	Symplekin_C	1091..1270	CDD:403495	76/182 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	142	1.000	Domainoid score	I1513
eggNOG	1	0.900	-	-		E1_KOG1895
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I948
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386749at2759
OrthoFinder	1	1.000	-	-		FOG0003988
OrthoInspector	1	1.000	-	-		otm2895
orthoMCL	1	0.900	-	-		OOG6_103157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3851
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730