DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sym and ESP4

DIOPT Version :9

Sequence 1:	NP_649580.1	Gene:	Sym / 40709	FlyBaseID:	FBgn0037371	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_195760.1	Gene:	ESP4 / 831597	AraportID:	AT5G01400	Length:	1467	Species:	Arabidopsis thaliana

Alignment Length:	1355	Identity:	301/1355 - (22%)
Similarity:	530/1355 - (39%)	Gaps:	266/1355 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ARAKVVDWCNELVIASP-STKCELLAKVQETVLGSCAELAEEFLESVLSLAHDSNMEVRKQVVAF 89
            :||::.|..|....|:. ..|.:.|..::..:....:....|.|..:..|..|....|||.|...
plant     5 SRARLKDLANSAKSATELPPKLQRLRYMRRDLQKDDSVFPTELLPHLFDLLSDQFGAVRKFVAEI 69

  Fly    90 VEQVCKVKVELLPHVINVVSMLLRDNSAQVIKRVIQACGS-IYKNGLQYLC----SLMEPGDSAE 149
            :.::....|||:|.::.::...|.|.:..|.::|| |||: ::::.|:.:.    ...|..|..|
plant    70 LGEIGLKYVELIPEIVPLLIKSLEDETPAVARQVI-ACGADLFRSTLERVAVQGLHSSELNDLLE 133

  Fly   150 QAWNILSLIKAQILDMIDNE-NDGIRTNAIKFLEGVVVLQSFADEDSLKRDGDFSLADVPDHCTL 213
            .:|..|...|.:|..:...: |.|::..|:||:|.:::|  :...:.:  :.||:::.:.....:
plant   134 SSWTWLIKFKDEICSVAFKQGNSGVKLCAMKFVEALILL--YTPHEGI--EADFNISILRGGHPV 194

  Fly   214 FRREKLQEEGNNILDIL---LQFHGTTHISSVNLIACTSSLCTIAKMRPIFMGAVVEAFKQLN-- 273
            .:...|..|.:..|.:|   |:......::|..:|...:||.::||.||.:.|.::.....|:
plant   195 LKIGDLSIEASQKLGLLLDQLRHPAAKSLNSSTIIVLINSLSSVAKKRPAYCGRILPVLLSLDPL 259

  Fly   274 ----------ANLP-------------PTLTDSQVSSVRKSLKMQLQT------LLKNRGAFEFA 309
                      .||.             |.....:::|..|.::...|.      ..|..|:.:..
plant   260 SFLKGVYAAATNLALKTVFLSCLKCTHPAAAPDRLTSALKEIEGGGQAAKAKDLFYKTNGSIQDK 324

  Fly   310 STIRGMLVDLGSSTNEIQKLIPKMDKQEMARRQKR------ILENAAQSLAKRARLACEQQDQQQ 368
            .::....|.:     |...|....|..|....:||      |..|...|..||||:.....::..
plant   325 DSVEDTKVSV-----EENPLCASSDVAESNLSRKRSGSEYNIDLNGDASDGKRARITPSVSEEST 384

  Fly   369 REME-LDTEELERQKQKSTRVNEKFLAEHFRNPETVV----TLV---------LEFLPS-----L 414
            ..:. .|...|.|....||..::..........:.:|    |||         ||.|.|     |
plant   385 DGLNGNDGVSLPRVASTSTGPSDSRGVSDSGPAQQLVGLFGTLVSQGEKAIGSLEILISSISADL 449

  Fly   415 PTEVPQKFLQEYTP------------IREMSI---QQQVTNISRFFGEQLSEKRLGPGAATF--- 461
            .|:|....:....|            :..|.|   ..|:.....|....||.....|..|..
plant   450 LTDVVMANMHNIPPNCSSYADGTDELVMNMCIVGSDAQIKYPPSFVAGVLSLSTAFPPIAALINP 514

  Fly   462 ---------------------SREPP----------------------------MRVKKVQAIES 477
                                 :|.||                            .|...:..:||
plant   515 HNEDEEVYSVHVDQQMFPAEDARTPPGLLATCDTSFPENEESNTVSPQNVHYIGNRESGIPGLES 579

  Fly   478 -----------TLTAMEVDEDAVQKLSEEEFQRK-------EEATKKLRETMERAKG-----EQT 519
                       |......:.:|..|.....|..|       ..:..||.|...:|.|     .|.
plant   580 SAQHDGSGALVTNVLSSTNVEAASKNQNASFSGKLLVDVIPSMSVDKLEEFSPKAVGTVASASQF 644

  Fly   520 VIEKMKERAKTLKLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKGGVSSKRRKLVTVIAATFP 584
            |:.|:......|..:|         |:........||:.:.:|....|.|..|..|:..:...||
plant   645 VLPKISAPVVDLSDEE---------KDSLQKLVFLRIVEAYKQISMSGGSQLRFSLLAHLGVEFP 700

  Fly   585 DNVRYG--IMEFILEDIKQRIDLAFSWLFEEYSLLQGFTRHTYVKTENRPD--------HAYNEL 639
            ..:...  :.|.:|.|....         |.:.|........|.:.|...|        .||...
plant   701 SELDPWKILQEHVLSDYLNH---------EGHELTVRVLYRLYGEAEAEQDFFSSTTAASAYESF 756

  Fly   640 LNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQ-------------LSLDDEFSQHG 691
            |..:...:.:.....||  .:.::..::|.||: |:..|::             |...|..:| |
plant   757 LLTVAEALRDSFPPSDK--SLSKLLGDSPHLPK-SVLMLLESFCCPGSGEVEKDLQHGDRVTQ-G 817

  Fly   692 LELIKDLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVS--LYHVHKILPARIDEFALEWL 754
            |..:..|.::||..:|..:.:.|..:||...::| :....||:  ||.: ..:..:|:|||.:.|
plant   818 LSAVWSLILMRPGIRNDCLNIALQSAVHHLEEIR-MKAIRLVANKLYSL-SFITEQIEEFAKDRL 880

  Fly   755 ----------KFIEQESPP----AAVFSQDFGRPTEEPDWREDTTKV--CFGLAFTLLPYKPEVY 803
                      ..::.:|||    .::.......|:|........|:.  |..|.|.|......::
plant   881 FSVVSDDCDKMDLDLKSPPNKPQHSISGMSMETPSEATSSSTSVTEAQRCLSLYFALCTKVLRIF 945

  Fly   804 ------LQQICQVFVSTSAELKRTILRSLDIPIKKMGVESPTLLQLIEDCPKGMETLVIRIIYIL 862
                  ...:..::.:.|..:|:.|...:.|.::.|| .|..||::|.|.|.|.:.|:|:::..|
plant   946 TILRLMTNLVFNIYKNASDPVKQAIHLQIPILVRTMG-SSSELLKIIADPPSGSDNLLIQVLQTL 1009

  Fly   863 TERVPSPHEELVRRVRDLYQNKVKDVRVMIPVLSGLTRSELISVLPKLIKLNPAVVKEVFNRLLG 927
            ||. |:|..||:..:|.|:..::|||.::.|:|..|.|.:::.:.|.::.|.....:...:|:|.
plant  1010 TEG-PTPSSELILTIRKLFDTRIKDVEILFPILPFLPRDDVLRIFPHMVNLPMEKFQVALSRVLQ 1073

  Fly   928 IGAEFAHQTMAMTPTDILVALHTIDTS--VCDIKAIVKATSLCLAERDLYTQEVLMAVLQQLVEV 990
            ..::   ....::|::.|:|:|:||.:  ...:|.:..|.:.|.|:|..:||:||..||.|||:.
plant  1074 GSSQ---SGPVLSPSEALIAIHSIDPARDGIPLKQVTDACNTCFAQRQTFTQQVLAGVLNQLVQQ 1135

  Fly   991 TPLPTLMMRTTIQSLTLYPRLANFVMNLLQRLIIKQVWRQKVIWEGFLKTVQRLKPQSMPILLHL 1055
            .|||.|.|||.:|::..:|.|::|::.:|.||:.||:|:...:|.||||..|..:|||..:||.|
plant  1136 IPLPMLFMRTVLQAIGAFPALSDFILEILSRLVSKQIWKYPKLWVGFLKCTQTTQPQSYKVLLQL 1200

  Fly  1056 PPAQLVDALQQCPDLRPALSEYAESMQDEPMNGSGITQQVLDIISGKSVDVFVTDESG------- 1113
            ||.||.:||.:.|.||..|:.:|    .:|...|.:.:..|.::.      .|.|..|
plant  1201 PPLQLGNALTKIPALRAPLTAHA----SQPEIQSSLPRSTLAVLG------LVPDSQGTQTSQVQ 1255

  Fly  1114 ---GYISAEHIKKEAPDPSEISVIS--TVPVLTSLVPLPVPPPIGSDLNQPLPPG 1163
               ...|.|..:::|.:|.:.|...  :||:..|.|....|..:.:..:|..|.|
plant  1256 ANETQTSQEQQQQQASEPQQTSQSQQVSVPLSHSQVDHQEPSQVVASQSQSSPIG 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sym	NP_649580.1	DUF3453	115..345	CDD:288763	53/275 (19%)
Sym	NP_649580.1	Symplekin_C	887..1067	CDD:289095	65/181 (36%)
ESP4	NP_195760.1	HEAT_2	<46..105	CDD:290374	17/59 (29%)
		HEAT repeat	46..74	CDD:293787	8/27 (30%)
		HEAT repeat	83..106	CDD:293787	5/23 (22%)
		DUF3453	95..311	CDD:288763	44/220 (20%)
		Symplekin_C	1033..1196	CDD:289095	56/165 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	142	1.000	Domainoid score	I1513
eggNOG	1	0.900	-	-		E1_KOG1895
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I948
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386749at2759
OrthoFinder	1	1.000	-	-		FOG0003988
OrthoInspector	1	1.000	-	-		otm2895
orthoMCL	1	0.900	-	-		OOG6_103157
Panther	1	1.100	-	-	LDO	PTHR15245
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3851
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830