Protein Alignment Sym and Sympk

DIOPT Version :10

• Sequence 1: NP_649580.1
• Gene: Sym / 40709
• FlyBaseID: FBgn0037371
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_080881.2
• Gene: Sympk / 68188
• MGIID: 1915438
• Length: 1288
• Species: Mus musculus
• Alignment Length: 1190
• Identity: 426/1190 - (35%)
• Similarity: 655/1190 - (55%)
• Gaps: 71/1190 - (5%)

  Fly     2 DSIIGR---SQFVSETANLFTDEKTATARAKVVDWCNELVIASPSTKCELLAKVQETVLGSCAEL 63
            ||:..|   |||.::......|..|.:.|  |||..|:..:.:..:|..:|.:|||.::.....|
Mouse     7 DSVTRRSVASQFFTQEEGPSIDGMTTSER--VVDLLNQAALITNDSKITVLKQVQELIINKDPTL 69

  Fly    64 AEEFLESVLSLAHDSNMEVRKQVVAFVEQVCKVKVELLPHVINVVSMLLRDNSAQVIKRVIQACG 128
            .:.||:.:::...|.::||||.|:.|:|:.||..:|||..:|..::|||||.:..|:|:.|....
Mouse    70 LDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMT 134

  Fly   129 SIYKNGLQYLCSLMEPGDSAEQAWNILSLIKAQILDMIDNENDGIRTNAIKFLEGVVVLQS--FA 191
            .:||..||::.......|..|..|:::|.:..:|:.::|::||||||:||||:||::|..|  .|
Mouse   135 QLYKVALQWMVKSRVISDLQEACWDMVSSMAGEIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMA 199

  Fly   192 DEDSLKR-DGDFSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISSVNLIACTSSLCTIA 255
            |.:..:| :.|.||..:|......:...|.|||...::.||:|.....|||:||.....||..||
Mouse   200 DSEVPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAAVEQLLKFMVHPAISSINLTTALGSLANIA 264

  Fly   256 KMRPIFMGAVVEAFKQLNANLPPTLTDSQVSSVRKSLKMQLQTLLKNRGAFEFASTIRGMLVDLG 320
            :.||:||..|::|::.|:|||||||..||||||||:||:.|.::||:..:.||.:.|..:|||||
Mouse   265 RQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLG 329

  Fly   321 SSTNEIQKLIPKMDKQEMARRQKRILENAAQSLAKRARLACEQQDQQQREMELDTEELERQ--KQ 383
            :...||.:.:|  ..::..:|.:...::..:.:.....|..:.:|:........|.:...|  .|
Mouse   330 TPQAEIARNMP--SSKDSRKRPRDDTDSTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQ 392

  Fly   384 KSTRVNEKFLAEHFRNPETVVTLVLEFLPSLPTEVPQKFLQEYTPIREMSIQQQVTNISRFFGEQ 448
            ..|.:..:|| :....|:.|..|||..:..||..:|..|...|||:.....:.|:.:::|....|
Mouse   393 SDTDITAEFL-QPLLTPDNVANLVLISMVYLPETMPASFQAIYTPVESAGTEAQIKHLARLMATQ 456

  Fly   449 LSEKRLGPGAATFS--REPPMRVKKVQ----------AIESTLTAMEVDEDAVQKLSEEEFQRKE 501
            ::...||||.....  :|.|...|.|:          :::....::...:..:..|.||..|.|.
Mouse   457 MTAAGLGPGVEQTKQCKEEPKEEKVVKPESVLIKRRLSVQGQAISVVGSQSTMSPLEEEVPQAKR 521

  Fly   502 EATKKLRETMERAKGEQTVIEKMKERAKTLKLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKG 566
            .....:..|..|..|       ...|.|..:|.::.|||.....|.....||:|||.:|:.....
Mouse   522 RPEPIIPVTQPRLAG-------AGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACS 579

  Fly   567 GVSSKRRKLVTVIAATFPDNVRYGIMEFILEDIKQRIDLAFSWLFEEY-SLLQGFTRHTYVKTEN 630
            |.:..|.|::..:...|....:..::.|||||::.|:||||:||::|| :.|...|..|..|
Mouse   580 GAAQVRIKILASLVTQFDSGFKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGTSGTLDK--- 641

  Fly   631 RPDHAYNELLNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLSLDDEFSQHGLELI 695
                 |.:.|..|:.|:.|:.|.||.|  ..:|.||||::.|.::..:.:...|:..:..|:..:
Mouse   642 -----YEDCLICLLSGLQEKPDQKDGI--FTKVVLEAPLITESALEVIRKYCEDESRAYLGMSTL 699

  Fly   696 KDLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVSLYHVHKILPARIDEFALEWLKFIEQE 760
            .||...||.|:.:::.|||:.|.||:..:|..|...:..:|...: |...:::|||.:|:.:...
Mouse   700 GDLIFKRPSRQFQYLHVLLDLSSHEKDRVRSQALLFIKRMYEKEQ-LREYVEKFALNYLQLLVHP 763

  Fly   761 SPPAAVFSQDFGRPTEEPDWREDTTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRS 825
            :||:.:|..|.......| |.|:|.|.|..|...|||...:: :.::..|:....|::|||:||.
Mouse   764 NPPSVLFGADKDTEVAAP-WTEETVKQCLYLYLALLPQNHKL-IHELAAVYTEAIADIKRTVLRV 826

  Fly   826 LDIPIKKMGVESPTLLQLIEDCPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRV 890
            ::.||:.||:.||.||.|:|:||||.||||.|.::.||::|| |..|||:||||||..::.|||.
Mouse   827 IEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVP-PSPELVKRVRDLYHKRLPDVRF 890

  Fly   891 MIPVLSGLTRSELISVLPKLIKLNPAVVKEVFNRLLGIGAEFAHQTMA-MTPTDILVALHTIDTS 954
            :||||:||.:.|:|..|||||||||.|||||||||||......:..:: :.|.::|:|||.||:.
Mouse   891 LIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSV 955

  Fly   955 VCDIKAIVKATSLCLAERDLYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLL 1019
            .||:|:|:|||:||.|||::||.|||..|:|||:|.:|||.|:|||.|||||:||||..||||:|
Mouse   956 KCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL 1020

  Fly  1020 QRLIIKQVWRQKVIWEGFLKTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDE 1084
            .|||:||||:...:||||:|..||.||||..::|.|||.||.....:||:||..|..:..|.  .
Mouse  1021 ARLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSF--T 1083

  Fly  1085 PMNGSGITQQVLDII--SGKSVDVFVTDESGGYISAEHIKKEAPD-PSEISVISTVPVLTSLVPL 1146
            |...:.|...::.|:  :||.               |...||||. |.|...:.  |:..:|.|.
Mouse  1084 PHQQAHIPNSIMTILEATGKQ---------------EPEVKEAPSGPLEEDDLE--PLALALAPA 1131

  Fly  1147 PVPPPIGSDLNQPLP-PGED 1165
            |.|.|..:....|.| |.:|
Mouse  1132 PAPAPAPAPAPAPAPRPPQD 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sym	NP_649580.1	PDS5	<1..>198	CDD:410996	69/200 (35%)
		HEAT repeat	43..96	CDD:410996	17/52 (33%)
		HEAT repeat	104..139	CDD:410996	13/34 (38%)
		SYMPK_PTA1_N	116..326	CDD:463403	85/212 (40%)
		HEAT repeat	154..187	CDD:410996	15/32 (47%)
		DUF5401	<332..>574	CDD:375164	55/255 (22%)
		Symplekin_C	887..1067	CDD:463523	105/180 (58%)
Sympk	NP_080881.2	Interaction with HSF1. /evidence=ECO:0000250	1..124		40/118 (34%)
		HEAT 3	104..146		16/41 (39%)
		SYMPK_PTA1_N	122..336	CDD:463403	86/213 (40%)
		HEAT 4	153..192		17/38 (45%)
		HEAT 5	227..266		16/38 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..392		7/58 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	345..360		1/14 (7%)
		Symplekin_C	887..1068	CDD:463523	105/180 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1130..1151		7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1163..1288