DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sym and sympk

DIOPT Version :9

Sequence 1:	NP_649580.1	Gene:	Sym / 40709	FlyBaseID:	FBgn0037371	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_989259.2	Gene:	sympk / 394872	XenbaseID:	XB-GENE-941660	Length:	1203	Species:	Xenopus tropicalis

Alignment Length:	1150	Identity:	417/1150 - (36%)
Similarity:	651/1150 - (56%)	Gaps:	69/1150 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SQFVSETANLFTDEKTATARAKVVDWCNELVIASPSTKCELLAKVQETVLGSCAELAEEFLESVL 72
            |||.|:...  |.|..:|:. :||:..|...:|:..:|..:|.:|||.::.....|.:.||:.::
Frog     7 SQFFSQEEG--TSEVVSTSE-RVVELLNMAALATNDSKITMLKQVQELIINKDPTLLDNFLDEII 68

  Fly    73 SLAHDSNMEVRKQVVAFVEQVCKVKVELLPHVINVVSMLLRDNSAQVIKRVIQACGSIYKNGLQY 137
            :...|.::||||.||.|:|:.||:..|||..:|..:.|||:|.:..|:|:.|.....:||..||:
Frog    69 AFQADKSVEVRKFVVNFIEEACKLDNELLIKLIANLHMLLKDENVNVVKKSILTMTQLYKVALQW 133

  Fly   138 LCSLMEPGDSAEQAWNILSLIKAQILDMIDNENDGIRTNAIKFLEGVVVLQSFADEDS---LKRD 199
            :.....|.:..|..|::::.:.|.||.:::::||||||:|:||:|.::|..|....||   .:::
Frog   134 VARSRPPSEQQESCWDLVTEMAADILLLLESDNDGIRTHAVKFVESLIVTLSPRTPDSEVPKRQE 198

  Fly   200 GDFSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISSVNLIACTSSLCTIAKMRPIFMGA 264
            ||.||..:|......:...|::.|...:..||:|.....|||:||.|...||.:||:.||:||..
Frog   199 GDISLEQIPSDHAFLKYNTLRDVGKQAVKELLKFMAHPAISSINLTAALGSLASIARQRPMFMAE 263

  Fly   265 VVEAFKQLNANLPPTLTDSQVSSVRKSLKMQLQTLLKNRGAFEFASTIRGMLVDLGSSTNEIQK- 328
            |::|::.|:|||||||..||||||||:||:||.::|::..::|:...|..:|:|||:|..||.:
Frog   264 VIQAYETLHANLPPTLAKSQVSSVRKNLKLQLLSVLRHPSSYEYQGPISTLLLDLGTSQGEITRH 328

  Fly   329 LIPKMDKQEMARRQKRILENAAQSLAK-RARLACEQQDQQQREMELDTEELER-QKQKSTRVNEK 391
            |.|..|.     .:||..|:......| |..:.....|..:..::|.|..... ..|.:|.:..:
Frog   329 LPPPRDS-----NRKRAREDGEGGQKKSRTDIPLPDDDDDKDTIQLPTIPAPAPSTQSATDITAE 388

  Fly   392 FLAEHFRNPETVVTLVLEFLPSLPTEVPQKFLQEYTPIREMSIQQQVTNISRFFGEQLSEKRLGP 456
            || ....:||.|..|||..:..||..:|..|...|||:.......|:.:::|....|::...:||
Frog   389 FL-RPLLSPENVANLVLISMVYLPDSMPASFQATYTPVESAGTDAQIRHLARLMATQMTSVGIGP 452

  Fly   457 GAATFSREPPMRVKKVQAIE----------STLT---AMEVDEDAVQKLSEEEFQRKEEA--TKK 506
            |... :::.|:.|.:.:..:          |.||   |:.|.....:|..||| :.:|:|  .||
Frog   453 GVEQ-TKDVPVDVVEEENTKPEGLVIKRRISALTKGQAISVLGCQSEKAKEEE-EEEEDAPLAKK 515

  Fly   507 -----LRETMERAKGEQTVIEKMKERAKTLKLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKG 566
                 |..|..|..|       :..|.|..:|:|:|:||.....:.....||:|||.:||.....
Frog   516 RPEPILPATQIRPSG-------VGGRKKVFRLKEVTEPLTEVQMKSLKLGAVQRILQAERTVGSS 573

  Fly   567 GVSSKRRKLVTVIAATFPDNVRYGIMEFILEDIKQRIDLAFSWLFEEYSLLQGFTRHTYVKTENR 631
            |.|..|.|::..:......:|:..::...|.|.:.|:|||.:||::||...|          ...
Frog   574 GASQMRVKVLARLVTQLDISVKAEVLSHFLSDPRMRLDLALAWLYQEYCEYQ----------SGA 628

  Fly   632 PDHAYNELLNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLSLDDEFSQHGLELIK 696
            .:.||.|.|..::.|:.||.|.:|.:  ..:|.||||:|.:.::..|.:...|:..|..|:..::
Frog   629 GEEAYQECLIGILTGLQERPDQRDGV--FTKVVLEAPLLTDSALDVLRKYCEDEGRSYLGMSTLR 691

  Fly   697 DLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVSLYHVHKILPARIDEFALEWLKFIEQES 761
            ||.:.||.|:.:::.:||:.|.||:..:|..:...:..:|....:.| .|::|||.:|:.:...:
Frog   692 DLILTRPARQFQYLHLLLDLSSHEKDKIRQQSLHFIKRMYEKESLRP-YIEKFALNYLQLLVHPN 755

  Fly   762 PPAAVFSQDFGRPTEEPDWREDTTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRSL 826
            ||:.:|..|.......| |.|||.|.|..|...|||...:: :.::..|:...:|::|||:||.:
Frog   756 PPSVLFGADKDTEVAAP-WTEDTVKQCLYLYLALLPQNHKL-IHELASVYTEATADIKRTVLRVI 818

  Fly   827 DIPIKKMGVESPTLLQLIEDCPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRVM 891
            :.||:.||:.||.||.|:|:||||.||||.|.::|||::|| |..|||:|||:||..::.|||.:
Frog   819 ETPIRGMGMNSPELLLLVENCPKGAETLVTRCLHILTDKVP-PSPELVKRVRELYHKRLPDVRFL 882

  Fly   892 IPVLSGLTRSELISVLPKLIKLNPAVVKEVFNRLLGI-GAEFAHQTMAMTPTDILVALHTIDTSV 955
            ||||:||.:.|:|..|||||||||.|||||||||||. ..|.:.....:||.|:|||||.||:|.
Frog   883 IPVLNGLDKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEVSSSMSPLTPGDLLVALHNIDSSK 947

  Fly   956 CDIKAIVKATSLCLAERDLYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLLQ 1020
            ||:|:::|||:||.:.|.:||.|||..|||||::.||||.|:|||.||:|.:||||..|:||:|.
Frog   948 CDMKSVIKATNLCFSARSVYTSEVLAVVLQQLMDTTPLPMLLMRTVIQALGMYPRLGGFIMNILT 1012

  Fly  1021 RLIIKQVWRQKVIWEGFLKTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDEP 1085
            |||.||||:...:||||:|..||.||||..:||.|||.||:..||..||||..|..:..:.  .|
Frog  1013 RLIYKQVWKYPKVWEGFIKCCQRTKPQSFSVLLQLPPPQLLSVLQTSPDLRDPLLVHVRAF--TP 1075

  Fly  1086 MNGSGITQQVLDIISGKSVDVFVTDESGGYISAEHIKKEAPDPSE 1130
            ...:.:...::.|:..:|     ..::|...||: :::|...|::
Frog  1076 HQLAHVPHSIMAILEAES-----RTDTGAEESAQ-VEEEQDTPAQ 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sym	NP_649580.1	DUF3453	115..345	CDD:288763	87/233 (37%)
Sym	NP_649580.1	Symplekin_C	887..1067	CDD:289095	108/180 (60%)
sympk	NP_989259.2	DUF3453	111..340	CDD:288763	87/233 (37%)
		PKc_like	<835..872	CDD:304357	23/37 (62%)
		Symplekin_C	878..1043	CDD:289095	99/164 (60%)
		Nnf1	<1088..1147	CDD:281911	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I2183
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37969
Inparanoid	1	1.050	676	1.000	Inparanoid score	I721
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132087at33208
OrthoFinder	1	1.000	-	-		FOG0003988
OrthoInspector	1	1.000	-	-		oto103926
Panther	1	1.100	-	-	LDO	PTHR15245
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1026
SonicParanoid	1	1.000	-	-		X3851
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190