Protein Alignment Sym and Sympk

DIOPT Version :10

• Sequence 1: NP_649580.1
• Gene: Sym / 40709
• FlyBaseID: FBgn0037371
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_001402715.1
• Gene: Sympk / 292683
• RGDID: 1306735
• Length: 1280
• Species: Rattus norvegicus
• Alignment Length: 1191
• Identity: 429/1191 - (36%)
• Similarity: 652/1191 - (54%)
• Gaps: 80/1191 - (6%)

  Fly     2 DSIIGR---SQFVSETANLFTDEKTATARAKVVDWCNELVIASPSTKCELLAKVQETVLGSCAEL 63
            ||:..|   |||.::......|..|.:.|  |||..|:..:.:..:|..:|.:|||.::.....|
  Rat     7 DSVTRRSVASQFFTQEEGPGIDGMTTSER--VVDLLNQAALITNDSKITVLKQVQELIINKDPTL 69

  Fly    64 AEEFLESVLSLAHDSNMEVRKQVVAFVEQVCKVKVELLPHVINVVSMLLRDNSAQVIKRVIQACG 128
            .:.||:.:::...|.:.||||.|:.|:|:.||..:|||..:|..::|||||.:..|:|:.|....
  Rat    70 LDNFLDEIIAFQADKSTEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMT 134

  Fly   129 SIYKNGLQYLCSLMEPGDSAEQAWNILSLIKAQILDMIDNENDGIRTNAIKFLEGVVVLQS--FA 191
            .:||..||::.......|..|..|:::|.:.|:|:.::|::||||||:||||:||::|..|  .|
  Rat   135 QLYKVALQWMVKSRVISDLQEACWDMVSSMAAEIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMA 199

  Fly   192 DEDSLKR-DGDFSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISSVNLIACTSSLCTIA 255
            |.:..:| :.|.||..:|......:...|.|||...|:.||:|.....|||:||.....||..||
  Rat   200 DSEVPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIA 264

  Fly   256 KMRPIFMGAVVEAFKQLNANLPPTLTDSQVSSVRKSLKMQLQTLLKNRGAFEFASTIRGMLVDLG 320
            :.||:||..|::|::.|:|||||||..||||||||:||:.|.::||:..:.||.:.|..:|||||
  Rat   265 RQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLG 329

  Fly   321 SSTNEIQKLIPKMDKQEMARRQKRILENAAQSLAKRARLACEQQDQQQREMELDTEELERQ--KQ 383
            :...||.:.:|  ..::..:|.:...|:..:.:.....|..:.:|:........|.:...|  .|
  Rat   330 TPQAEIARNMP--SSKDSRKRPRDDTESTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQ 392

  Fly   384 KSTRVNEKFLAEHFRNPETVVTLVLEFLPSLPTEVPQKFLQEYTPIREMSIQQQVTNISRFFGEQ 448
            ..|.:..:|| :....|:.|..|||..:..||..:|..|...|||:.....:.|:.:::|....|
  Rat   393 SDTDITAEFL-QPLLTPDNVANLVLISMVYLPETMPASFQAIYTPVESAGTEAQIKHLARLMATQ 456

  Fly   449 LSEKRLGPGAATFS--REPPMRVKKVQ----------AIESTLTAMEVDEDAVQKLSEEEFQRKE 501
            ::...||||.....  :|.|...|.|:          :::....::...:..:..|.||..|.|.
  Rat   457 MTAAGLGPGVEQTKQCKEEPKEEKVVKPESVLIKRRLSVQGQAISVVGSQSTMSPLEEEVPQAKR 521

  Fly   502 EATKKLRETMERAKGEQTVIEKMKERAKTLKLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKG 566
            .....:..|..|..|       ...|.|..:|.::.|||.....|.....||:|||.:|:.....
  Rat   522 RPEPIIPVTQPRLAG-------AGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACS 579

  Fly   567 GVSSKRRKLVTVIAATFPDNVRYGIMEFILEDIKQRIDLAFSWLFEEY-SLLQGFTRHTYVKTEN 630
            |.:..|.|::..:...|....:..::.|||||::.|:||||:||::|| :.|......|..|
  Rat   580 GAAQVRIKILASLVTQFDSGFKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGPSGTLDK--- 641

  Fly   631 RPDHAYNELLNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLSLDDEFSQHGLELI 695
                 |.:.|..|:.|:.|:.|.||.|  ..:|.||||::.|.::..:.:...|:..:..|:..:
  Rat   642 -----YEDCLICLLSGLQEKPDQKDGI--FTKVVLEAPLITESALEVIRKYCEDESRAYLGMSTL 699

  Fly   696 KDLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVSLYHVHKILPARIDEFALEWLKFIEQE 760
            .||...||.|:.:::.|||:.|.||:..:|..|...:..:|...: |...:::|||.:|:.:...
  Rat   700 GDLIFKRPSRQFQYLHVLLDLSSHEKDRVRSQALLFIKRMYEKEQ-LREYVEKFALNYLQLLVHP 763

  Fly   761 SPPAAVFSQDFGRPTEEPDWREDTTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRS 825
            :||:.:|..|.......| |.|:|.|.|..|...|||...:: :.::..|:....|::|||:||.
  Rat   764 NPPSVLFGADKDTEVAAP-WTEETVKQCLYLYLALLPQNHKL-IHELAAVYTEAIADIKRTVLRV 826

  Fly   826 LDIPIKKMGVESPTLLQLIEDCPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRV 890
            ::.||:.||:.||.||.|:|:||||.||||.|.::.||::|| |..|||:||||||..::.|||.
  Rat   827 IEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVP-PSPELVKRVRDLYHKRLPDVRF 890

  Fly   891 MIPVLSGLTRSELISVLPKLIKLNPAVVKEVFNRLLGIGAEFAHQTMA-MTPTDILVALHTIDTS 954
            :||||:||.:.|:|..|||||||||.|||||||||||......:..:: :.|.::|:|||.||:.
  Rat   891 LIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSV 955

  Fly   955 VCDIKAIVKATSLCLAERDLYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLL 1019
            .||:|:|:|||:||.|||::||.|||..|:|||:|.:|||.|:|||.|||||:||||..||||:|
  Rat   956 KCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL 1020

  Fly  1020 QRLIIKQVWRQKVIWEGFLKTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDE 1084
            .|||:||||:...:||||:|..||.||||..::|.|||.||.....:||:||..|..:..|.  .
  Rat  1021 ARLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSF--T 1083

  Fly  1085 PMNGSGITQQVLDII--SGKSVDVFVTDESGGYISAEHIKKEAP------DPSEISVISTVPVLT 1141
            |...:.|...::.|:  |||.               |...||||      |..|...::..|
  Rat  1084 PHQQAHIPNSIMTILEASGKQ---------------EPEVKEAPSGSLEEDDLEPLALALAP--- 1130

  Fly  1142 SLVPLPVPPP----IGSDLNQ 1158
            :|.|.|.|.|    ||..|.|
  Rat  1131 ALAPAPAPRPPQDLIGLRLAQ 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sym	NP_649580.1	PDS5	<1..>198	CDD:410996	70/200 (35%)
		HEAT repeat	43..96	CDD:410996	17/52 (33%)
		HEAT repeat	104..139	CDD:410996	13/34 (38%)
		SYMPK_PTA1_N	116..326	CDD:463403	87/212 (41%)
		HEAT repeat	154..187	CDD:410996	16/32 (50%)
		DUF5401	<332..>574	CDD:375164	56/255 (22%)
		Symplekin_C	887..1067	CDD:463523	105/180 (58%)
Sympk	NP_001402715.1	SYMPK_PTA1_N	122..336	CDD:463403	88/213 (41%)
		Symplekin_C	887..1068	CDD:463523	105/180 (58%)