DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2100 and hpo-31

DIOPT Version :9

Sequence 1:	NP_001163512.1	Gene:	CG2100 / 40707	FlyBaseID:	FBgn0037369	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001023976.1	Gene:	hpo-31 / 3565786	WormBaseID:	WBGene00010089	Length:	436	Species:	Caenorhabditis elegans

Alignment Length:	431	Identity:	192/431 - (44%)
Similarity:	265/431 - (61%)	Gaps:	32/431 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PAFRKVATPEFKSIFTPELNDLVALFKKYDYELRIAGGAVRDILMGIPPKDIDLATTATPDQMKQ 122
            |...|:...:|:::|||:|..|..||.|.:||||||||||||:||.|.|.|:|.|:||||.|||:
Worm     6 PTTMKIDNEDFRTLFTPQLLKLRDLFAKRNYELRIAGGAVRDLLMNIRPADVDFASTATPTQMKE 70

  Fly   123 MFEKEEVRMINANGEKHGTITPRINDKENFEVTTLRIDIRTDGRHAEVMYTTDWQLDANRRDLTI 187
            |||::::||::..||:|||||.||:|.||||:||||:||..|||.|:|.||||||||||||||||
Worm    71 MFEEDKIRMLHKRGEEHGTITCRIDDCENFEITTLRVDIVCDGRRAQVEYTTDWQLDANRRDLTI 135

  Fly   188 NSMFLGFDGTVYDYFYGYDDLQERRVVFVGEADIRIKEDFLRILRYFRFYGRIAS-EENNHDKAT 251
            ||:||...|.|.|||.|..|::.||:.|||:|..||:||:|||||||||:|||:. .|:.||  |
Worm   136 NSLFLDLHGNVVDYFGGIRDIETRRIAFVGDARQRIQEDYLRILRYFRFFGRISDCTEHEHD--T 198

  Fly   252 LAAIKENAKGLARISGERIWSELQKIVPGNFGAALFLEM-HRCNLFEYIGLPKEPYLDEFDRLCK 315
            :.||.||..|:|.||.||||:||:|||.|.....:...| .:|.|.:|:|||||..|:.|..:
Worm   199 IQAIVENKDGMAGISAERIWTELKKIVVGRMADEVLKAMIEQCELQKYLGLPKECNLERFHTV-- 261

  Fly   316 ALDQFEKPHQPILYLAGMLHSVEDAMEMHKRLKLSAYERDLARFITQEREKVGSQYTTLRDYQKL 380
             .::|.|..:|:..:|.:........|.|:..|||..||.|..||..||:   |....|:: ...
Worm   262 -FNRFSKTVEPMTMIACLCEDEHQIAEFHRITKLSNDERLLGEFILSERQ---SAVENLKN-DDW 321

  Fly   381 CLQKYI----------QRDFVEQLLKYSGKLELYNQ-----LKSWVKPDFPIRGNALAQRGL-NG 429
            .:.:.:          |:|.:.|.|....|..|.::     ::::..|.|||.|..|.:.|: .|
Worm   322 WIDRIVDLEVRPGHENQQDRLRQRLVQLAKSVLADEERIQMIENFEAPKFPITGRDLMEAGVRKG 386

  Fly   430 MRLGLVMDELKLLWADSDFQLTHDDLLKW-----IPNVLKK 465
            ..:..|:..|..||.:|.|..:...||:.     ||::.|:
Worm   387 PHVRNVLYYLYNLWKESRFTESKYSLLERAKDSDIPDLSKE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2100	NP_001163512.1	PcnB	71..465	CDD:223690	188/416 (45%)
		NT_ClassII-CCAase	73..210	CDD:143388	90/136 (66%)
		PolyA_pol_RNAbd	248..302	CDD:289399	25/54 (46%)
hpo-31	NP_001023976.1	PcnB	19..417	CDD:223690	186/406 (46%)
		PolyA_pol	38..161	CDD:280000	82/122 (67%)
		PolyA_pol_RNAbd	195..250	CDD:289399	26/56 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159402
Domainoid	1	1.000	176	1.000	Domainoid score	I2161
eggNOG	1	0.900	-	-		E1_COG0617
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9333
Inparanoid	1	1.050	320	1.000	Inparanoid score	I1497
Isobase	1	0.950	-	0	Normalized mean entropy	S2643
OMA	1	1.010	-	-		QHG48492
OrthoDB	1	1.010	-	-		D512946at33208
OrthoFinder	1	1.000	-	-		FOG0001890
OrthoInspector	1	1.000	-	-		oto20459
orthoMCL	1	0.900	-	-		OOG6_103014
Panther	1	1.100	-	-	LDO	PTHR46173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R174
SonicParanoid	1	1.000	-	-		X1426
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790