DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1239 and mepcea

DIOPT Version :9

Sequence 1:	NP_001287185.1	Gene:	CG1239 / 40706	FlyBaseID:	FBgn0037368	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_001122001.1	Gene:	mepcea / 561384	ZFINID:	ZDB-GENE-030131-3936	Length:	701	Species:	Danio rerio

Alignment Length:	441	Identity:	135/441 - (30%)
Similarity:	193/441 - (43%)	Gaps:	150/441 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LENNNNTPLTGKQAE------KCA----------------KKRKCVITLDEKQVESKRLKK---- 41
            ||::|.:.||....|      .|:                :||:...:..|....|..:|:
Zfish   261 LESSNKSSLTSNDNEVKEKTVDCSTAHLTANPTNPPSSRQRKRRRAGSRTENSSSSSEVKRSGRH 325

  Fly    42 ----------EESNVEATSRP-PAQSPKKRLHLNGKPMQNKDLNFKYGNYKHYYGKRILNKDF-H 94
                      ..|.|....:| |.|...:..:.|..|.|.|. .|:||||..|||.|  |... .
Zfish   326 FQHNESQGGNSRSGVSDRQQPYPNQWRPQYSNNNQNPQQPKK-KFQYGNYNKYYGYR--NPGMSE 387

  Fly    95 DIRLDVLGTQPDLFRNKQLLDIGCNSGHLSIQIARKFEVKSLVGLDIDRGLINDAQKTVSHL--- 156
            |.|:.|:  .||.||.|.:||:|||:|||::.||:.:...|:||||||..||:.|::.:.|.
Zfish   388 DPRIRVM--NPDWFRGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQNIRHYLSE 450

  Fly   157 -----------------------------------------------------------KRHATP 162
                                                                       ||.|..
Zfish   451 VQVQHSRRSGENTKADRGEVSGEEKDKDKTSLVMDEKKAKHVDEVNKCMDEGMEVNQEEKREADR 515

  Fly   163 GQ----------------------------GIP----------------HIQFVHGNYVLEDDVL 183
            |:                            |.|                ::.|:.||||||.|||
Zfish   516 GEIGDGASVDLPDGKHSFPVSLRISRGPIAGPPLPETNTHSLPPGDFPANVTFIKGNYVLESDVL 580

  Fly   184 LEIERPQFDVILCLSVTKWIHLNFCDSGLKQAFRRMYLQLRPGGKLILEPQSFDGYKRRKKLSEQ 248
            |:.:|.::|||||||||||:|||:.|:|||:.|.|:|..|||||..|||||.:..|.:||||:|.
Zfish   581 LQTQREEYDVILCLSVTKWVHLNWGDAGLKRFFHRVYKHLRPGGLFILEPQPWSSYNKRKKLTEA 645

  Fly   249 IRDNYNAIKFRPDHFTEYLLSPEVGFAEMKLMGIPEHCKVGFKRPIQIFTK 299
            |..||::|:.:||.|:.: |:.||||:..:|:|..::...||:|||.::.|
Zfish   646 ICKNYHSIRLKPDQFSSF-LTTEVGFSSYELIGTSQNYSKGFQRPISLYHK 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1239	NP_001287185.1	Methyltransf_18	109..233	CDD:289607	69/229 (30%)
CG1239	NP_001287185.1	Bin3	191..299	CDD:284317	56/107 (52%)
mepcea	NP_001122001.1	Methyltransf_25	404..>455	CDD:316196	21/50 (42%)
mepcea	NP_001122001.1	Bin3	588..695	CDD:311052	56/107 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589286
Domainoid	1	1.000	124	1.000	Domainoid score	I5449
eggNOG	1	0.900	-	-		E1_KOG2899
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185441at2759
OrthoFinder	1	1.000	-	-		FOG0003359
OrthoInspector	1	1.000	-	-		otm24354
orthoMCL	1	0.900	-	-		OOG6_103556
Panther	1	1.100	-	-	O	PTHR12315
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2246
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.710