Protein Alignment plx and RABGAP1L

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001353375.1
• Gene: RABGAP1L / 9910
• HGNCID: 24663
• Length: 1051
• Species: Homo sapiens
• Alignment Length: 1160
• Identity: 244/1160 - (21%)
• Similarity: 448/1160 - (38%)
• Gaps: 269/1160 - (23%)

  Fly   391 DDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKEN--KSPEKRP---LLRGQSQIELGHKEHSDGS 450
            |:|...:.||.:::...|.|:      ||...|.  :..||||   |:..||..|:  .:||.|.
Human    34 DNSTKHEEKPQLKIVSNGDEQ------LEKAMEEILRDSEKRPSSLLVDCQSSSEI--SDHSFGD 90

  Fly   451 QPLAANSQLEAPNVIV-----NKQPTPPRDQGVG---------------TGTASASAGPSQLHPN 495
            .|.   ||...|::.:     |.:.:.||....|               .|....|:..:::...
Human    91 IPA---SQTNKPSLQLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEAL 152

  Fly   496 YAMDNIPKQRDRSASQGCIPP--YVEQNRTMVFLVGRCDLRLISPDRK-QVLLYKDFKDVASCVH 557
            .||..:     :|:||...|.  ||..       |....:|:|..... ::..:..:| |..|..
Human   153 RAMATM-----KSSSQYPFPVTLYVPN-------VPEGSVRIIDQSSNVEIASFPIYK-VLFCAR 204

  Fly   558 GQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCE--H 620
            |               :||        .:|..|        .||...:...::....:||||  .
Human   205 G---------------HDG--------TTESNC--------FAFTESSHGSEEFQIHVFSCEIKE 238

  Fly   621 CPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLL 685
            ......:..||..:            |....:||.:..::            |..:.:.|...:.
Human   239 AVSRILYSFCTAFK------------RSSRQVSDVKDSVI------------PTPDSDVFTFSVS 279

  Fly   686 RAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAV------ 744
            ....|...:.:.....::|.:|          :.|.|:.:.......:::..:| ::|:
Human   280 LEVKEDDGKGNFSPVPKDRDKF----------YFKLKQGIEKKVVITVQQLSNK-ELAIERCFGM 333

  Fly   745 ---PSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVG-NSPK 805
               |.   |:::......|..:|..:.:..|:..:..          :.:|...:|:.:. .:||
Human   334 LLSPG---RNVKNSDMHLLDMESMGKSYDGRAYVITG----------MWNPNAPVFLALNEETPK 385

  Fly   806 EAETHQGSWRQAILNSVVTPSKGLDSEVP-----------------TE-FLSPMRKPAKRGKRDA 852
            :.:.:.......::..||.|.:.|...|.                 || |...:::...:|..:|
Human   386 DKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHTNA 450

  Fly   853 AELRELWRTAIRQTIMLNRMETENAML---------------QARQNENELKRIKLDYEEIVPCD 902
            .:       ||.:.:.|.|...:...:               ...:::|||.....|..:  .|.
Human   451 GD-------AIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSK--DCP 506

  Fly   903 KQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPN 967
            ::::..|.:::.:..:.:|.:  ||.|...:::|||.:.|.:||..||..|. |.|.:|.
Human   507 EKILYSWGELLGKWHSNLGAR--PKGLSTLVKSGVPEALRAEVWQLLAGCHD-NQAMLDR----- 563

  Fly   968 FNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLG 1032
                |.:|:...:..:..|..|:.||||.|.::||..|.||.||:.:.||||:.|.::|||||..
Human   564 ----YRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQS 624

  Fly  1033 FICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQND 1097
            |:..|||||..|..:|.:|..:|:...:|..|..:.:....:.|||.||:::.||||:......:
Human   625 FLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLN 689

  Fly  1098 VSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMD 1162
            :...:||:.|.||:|:::|||..|..:.|||..|..::||..|:|||...|:.||..| ||..:.
Human   690 LEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQAD-FEGALK 753

  Fly  1163 YLKTVVPK-----------MEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEML 1216
            :.:..:||           ||..|..::..        |:|.:|:.||..::|........::..
Human   754 FFRVQLPKRYRAEENARRLMEQACNIKVPT--------KKLKKYEKEYQTMRESQLQQEDPMDRY 810

  Fly  1217 NREKTQNQHLEQQLQFAQSSIA-QLETTRSSQQAQITTLQSQV----QSLELTIQTLGRYVGQLV 1276
            .||..:.|....:|:.....:| :|.|::.:.:..:...:.:.    :.|.||.|.|
Human   811 KRENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLLTKQRL-------- 867

  Fly  1277 EHNPDLELPNEVRRMLQQLDDLDRQRRKPI-FTERKIGKSVSVNSHLGFPLKVLEELTERDELGS 1340
                 :|...|.|:..::...|....||.: ..|.:|.|:.::.:........|....|:.:..|
Human   868 -----VETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLSTRLEKQQAAS 927

  Fly  1341 PQ-----KQKKEKTPFFEQLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPN-----RLLDNASAR 1395
            .:     |.|.........:..::...:|...|:.    :.|..|...:.:     |.::...|:
Human   928 KEELEVVKGKMMACKHCSDIFSKEGALKLAATGRE----DQGIETDDEKDSLKKQLREMELELAQ 988

  Fly  1396 TVMQV-----KLDELKLPEHVDKFVAN----------IKSPLEVDSGVGT-PLSP 1434
            |.:|:     |:.||   ||....:.|          .|:...:.:..|| ||.|
Human   989 TKLQLVEAKCKIQEL---EHQRGALMNEIQAAKNSWFSKTLNSIKTATGTQPLQP 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	49/237 (21%)
		DUF3350	831..880	CDD:463365	10/81 (12%)
		TBC	933..1152	CDD:214540	80/218 (37%)
		COG4372	<1190..>1353	CDD:443500	32/173 (18%)
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		4/17 (24%)
		PTB_Rab6GAP	129..257	CDD:269922	30/183 (16%)
		DUF3694	290..421	CDD:463599	20/154 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..503		5/41 (12%)
		TBC	535..744	CDD:214540	80/218 (37%)
		Smc	<794..>1020	CDD:440809	41/245 (17%)