Protein Alignment plx and SGSM2

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_011522403.1
• Gene: SGSM2 / 9905
• HGNCID: 29026
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 878
• Identity: 149/878 - (16%)
• Similarity: 274/878 - (31%)
• Gaps: 315/878 - (35%)

  Fly   358 EGGVGIEAKPSSSLKSHDLKE------EDEEEQEQHKGH--------------------DDSQDS 396
            :|.|..:.:..||::|.|::|      .|...:..:.||                    ||.::.
Human   433 KGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDEEE 497

  Fly   397 QAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEA 461
            :.|....|.:..:....||.|::|              ....||:      .|..|......||
Human   498 EDKLHAMLSMICSRNLTAPNPMKD--------------AGDMIEM------QGFGPSLPAWHLE- 541

  Fly   462 PNVIVNKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVF 526
                      |...||....:.|:|:.| ...|::.              .|||
Human   542 ----------PLCSQGSSCLSCSSSSSP-HATPSHC--------------SCIP----------- 570

  Fly   527 LVGRCDLRLISPDRKQVLLYKDFKD-VASCVH------GQKSLDHFGIICRE--------LNNDG 576
              .|..|||:....|:.::.:.|.. :|.|.|      ...:|.|..:|..:        |..|.
Human   571 --DRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDV 633

  Fly   577 YIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKT 641
            :..|    |.:......:..:.|.:....|.:.::|...|      :|.::|.     |:|:|:
Human   634 WSKY----QKDKKNYKELELLRQVYYGGIEHEIRKDVWPF------LLGHYKF-----GMSKKE- 682

  Fly   642 QALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCE---SRQQRHVHDTAEN 703
                                     .|:.::.||.:.|.::...:| ||   .:::|..|.....
Human   683 -------------------------MEQVDAVVAARYQQVLAEWKA-CEVVVRQREREAHPATRT 721

  Fly   704 RSEFLNQYLGGSTIFMKAKRSL----TNSFDNLLKRKPSKDDIAVPS-HNLRDIREGSAEPLGTQ 763
            :      :..||:|....:|.:    |.|.|..:    |.||:..|. .:..|.|....:..|..
Human   722 K------FSSGSSIDSHVQRLIHRDSTISNDVFI----SVDDLEPPEPQDPEDSRPKPEQEAGPG 776

  Fly   764 SPPEGFRSRSNTV------GASPSSK--PTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILN 820
            :|......:.::|      ...|||:  ..|..::| .:|....||...::....:||
Human   777 TPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQS-SLDEGQSVGFEEEDGGGEEGS------- 833

  Fly   821 SVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELREL-------WRTAIRQTIMLNRMETENAM 878
                ...|..:....|...|.::..:.|:.:|.|  ||       :...:..|:.||
Human   834 ----SGPGPAAHTLREPQDPSQEKPQAGELEAGE--ELAAVCAAAYTIELLDTVALN-------- 884

  Fly   879 LQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRG 943
                     |.||..|.:.   ||:
Human   885 ---------LHRIDKDVQR---CDR---------------------------------------- 897

  Fly   944 DVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQ 1008
            :.|.|..               ||......::..::.||
Human   898 NYWYFTP---------------PNLERLRDVMCSYVWEH-------------------------- 921

  Fly  1009 LSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCD-EANSFQLLKHLMFRRNMRTKYLPDMKKFQ 1072
                        ||  :||.||:..:...||:..| :..::....|||.|.:..   .|:.....
Human   922 ------------LD--VGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN---FPNGGAMD 969

  Fly  1073 LQLYQLSRLVKDHLPDLYVWLDQN-DVSPTLYAAPWILTVFSSQFPLGFVARVFDLLF----LES 1132
            .....:..|::....:|:..:.|| |.:...:...|.|..|..:.....|..|:::::    :.|
Human   970 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISS 1034

  Fly  1133 SDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLK 1165
            ...:...|:||:..:::  :.:||..:..|.:|
Human  1035 EHFVLFIALALVEAYRE--IIRDNNMDFTDIIK 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	51/283 (18%)
		DUF3350	831..880	CDD:463365	10/55 (18%)
		TBC	933..1152	CDD:214540	34/224 (15%)
		COG4372	<1190..>1353	CDD:443500
SGSM2	XP_011522403.1	RUN	18..243	CDD:459241
		PH_RUTBC	302..470	CDD:275431	8/36 (22%)
		TBC	<885..1053	CDD:214540	40/270 (15%)