DRSC/TRiP Functional Genomics Resources

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Protein Alignment plx and TBC1D4

DIOPT Version :10

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:NP_055647.2 Gene:TBC1D4 / 9882 HGNCID:19165 Length:1298 Species:Homo sapiens


Alignment Length:1503 Identity:429/1503 - (28%)
Similarity:646/1503 - (42%) Gaps:475/1503 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LTFRGSASVDPRYSASMLPWTINDIRSTESYTKLSVGIENGILESYNSDFELQFSHPLKHIVGMC 72
            |.:.|.:.:|.|.:..||||.:.:||                                       
Human    38 LWYVGGSCLDHRTTLPMLPWLMAEIR--------------------------------------- 63

  Fly    73 RIIHKPQAKSIG------------NGFLQLKSSAGQTSSSSAVASSMGGAASSSLTGNGLRHTLT 125
            |...||:|...|            ..||:...:.|        |.:.||.:.|:...|       
Human    64 RRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPG--------AGASGGTSPSATQPN------- 113

  Fly   126 ASTSYGSLSSSAACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVYLLK-DPKDPLLHIYLFECE 189
                      .|...:        |..|:....|:.....:|...||:| .|.||          
Human   114 ----------PAVFIF--------EHKAQHISRFIHNSHDLTYFAYLIKAQPDDP---------- 150

  Fly   190 AVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMRNA 254
             ..:||..:.:..||:..                                               
Human   151 -ESQMACHVFRATDPSQV----------------------------------------------- 167

  Fly   255 QHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPN--------HTHFFE 311
                 |:.:||..:.||:                        ::..|..|:        ::..||
Human   168 -----PDVISSIRQLSKA------------------------AMKEDAKPSKDNEDAFYNSQKFE 203

  Fly   312 VMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDL 376
            |:|.||:.|:.|:.|::.|||.:.||..::.|||::                             
Human   204 VLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKI----------------------------- 239

  Fly   377 KEEDEEEQEQHKGHDDSQDSQAKPLVQLQLT--GAEEGAAPRPLEDNKENKSPEKRPLLRGQSQI 439
                   |.:.:|.|..:|     |..|::.  |:.....|                        
Human   240 -------QGEQRGPDPGED-----LADLEVVVPGSPGDCLP------------------------ 268

  Fly   440 ELGHKEHSDG-----------SQPLAANSQLEAPNVIVNKQPTPPRDQGVG------TGTASASA 487
                 |.:||           |||...:|::..|..|:       .|.|..      :..:|.:.
Human   269 -----EEADGTDTHLGLPAGASQPALTSSRVCFPERIL-------EDSGFDEQQEFRSRCSSVTG 321

  Fly   488 GPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDV 552
            ...::|.. :..:.|::|..||.....|...|:||||:|.|||.::.|||||.|.|:|.|:|||:
Human   322 VQRRVHEG-SQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDI 385

  Fly   553 ASCVHGQKSLDHFGIICRELNNDG---YIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQ 614
            :||..|.|.:||||.||||....|   ||.|||:|.||.:.|:::..:.|||.|.|..:..: ||
Human   386 SSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAK-TQ 449

  Fly   615 IFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVA--EQ 677
            |..||.|||...||||..:|||...:.:.:|.|.:.:|:|:||..::.:.    :...||:  |:
Human   450 IKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERV----QKMKPVSDQEE 510

  Fly   678 NQFLMMLLRAHCESRQQRHVH-----DTAENRSEFLNQYLGG----STIFMKAKRSLTNSFDNLL 733
            |:.:::.||..||::|:.|||     .|..|.:...|....|    ..:..|||||||:|.:|:.
Human   511 NELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIF 575

  Fly   734 KRKPSK-------DDIAVPSHNL---RDIREGSAEPLGT--QSPPEG--------------FRSR 772
            .|..::       .|....|::|   :|...|.:.| ||  .|||..              ||.|
Human   576 SRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPP-GTPPASPPSSAWQTFPEEDSDSPQFRRR 639

  Fly   773 SNTVGASPSSKP--------TAEQLKSPMM----------------------------------- 794
            ::|....|||..        .|:.::||::                                   
Human   640 AHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFS 704

  Fly   795 ------DIFIK--VGNSPK---------------EAETHQG------------------------ 812
                  ..|:|  ..||.:               |:...:|                        
Human   705 APSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRR 769

  Fly   813 -SWRQAILNSVVTP----------SKGLDSE--VPTEFLSPMRK-------------PAK-RGKR 850
             ||||.|...|.:|          ..|||..  :|...|||..:             |.| ..::
Human   770 ISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERK 834

  Fly   851 DAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIER 915
            .:.|||.|||.||.|.|:|.|||.||..|:|.::|.:.:::||||||:..|.|:::..|::.:..
Human   835 KSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN 899

  Fly   916 NSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTP----YHMLL 976
            ...:|  :.|.:.:...::.|||:|:||::|.|||.|:.:.      .|.||...|    |..||
Human   900 CRAKI--RCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLR------HRLPNKQQPPDISYKELL 956

  Fly   977 KHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLH 1041
            |.||..||||.:|||||||.|.::...||.|||||||||||||:||.|:|||||:.|:.||||||
Human   957 KQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLH 1021

  Fly  1042 CDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAP 1106
            ..|..:|::||.||:....|.:|.|||...|:|:||||||:.|:..|||..|::|::||:|||||
Human  1022 MSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAP 1086

  Fly  1107 WILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKM 1171
            |.||:|:|||.|||||||||::||:.::||||.|::|||..:..::..::||.|:::||..:|.|
Human  1087 WFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDM 1151

  Fly  1172 EHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHH------LEMLNRE----KTQNQHL 1226
            ..:.||:|:..||.|||.|||..|:|||:|||:|:..:::.      ||.|.|.    |.||..|
Human  1152 NTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDL 1216

  Fly  1227 EQQLQFAQSSIAQLE-------TTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLEL 1284
            .::||.|.:.|..||       |..:..::.|.||:.:..:.:.|::.|.:.:......|.||.|
Human  1217 LEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLL 1281

  Fly  1285 ------PN 1286
                  ||
Human  1282 RDLNCNPN 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967 89/329 (27%)
DUF3350 831..880 CDD:463365 22/64 (34%)
TBC 933..1152 CDD:214540 121/222 (55%)
COG4372 <1190..>1353 CDD:443500 37/120 (31%)
TBC1D4NP_055647.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
PTB 31..190 CDD:214675 45/310 (15%)
PTB_TBC1D1_like 193..437 CDD:269967 87/321 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..287 11/79 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..353 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 586..685 21/99 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..765 2/39 (5%)
DUF3350 801..864 CDD:463365 22/62 (35%)
TBC 918..1132 CDD:214540 121/219 (55%)
COG4372 1161..>1267 CDD:443500 36/105 (34%)
Blue background indicates that the domain is not in the aligned region.

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