Protein Alignment plx and GYP5

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_015075.1
• Gene: GYP5 / 855827
• SGDID: S000006170
• Length: 894
• Species: Saccharomyces cerevisiae
• Alignment Length: 1067
• Identity: 257/1067 - (24%)
• Similarity: 393/1067 - (36%)
• Gaps: 273/1067 - (25%)

  Fly   369 SSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLL 433
            ||.||.: |..|....|.|:|.:.|.:          |...||.....|.:..:|.......||
Yeast     2 SSDKSIE-KNTDTIASEVHEGDNHSNN----------LGSMEEEIKSTPSDQYEEIAIIPTEPL- 54

  Fly   434 RGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGPSQLHPNYAM 498
              .|..||..|:.|.|.: ...|...|.|..|...:.|...:|.|...........|::..|..:
Yeast    55 --HSDKELNDKQQSLGHE-APTNVSREEPIGISGDEDTQITEQNVNEQRQETREPSSEIDLNEPL 116

  Fly   499 D---------------NIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKD 548
            |               ||.|:.|.          |::|..                     :|.|
Yeast   117 DVEKDVTTDVQAPNGLNIEKEYDA----------VKENEK---------------------VYAD 150

  Fly   549 FKDVASCVHGQKSLDHFGIICREL---NNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKK 610
            .|:|.|....           ||:   |:.|.     |..|....||.......|        ..
Yeast   151 TKEVVSSPEN-----------REVTGKNSGGE-----KSSSSKFLDDESGTTTAA--------NA 191

  Fly   611 QDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVA 675
            .|..|.|                |...|:.::           :|..:|        ..||...|
Yeast   192 NDISISS----------------EVTPERSSE-----------NDNNQI--------HITNEVAA 221

  Fly   676 EQNQFLMMLLRAHCESRQQRHVHD---TAEN-RSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRK 736
            ..|      |..:.|  |:..:.|   |||| .||...:.....|..:..|..  ||.:|.:...
Yeast   222 GIN------LNENKE--QKAAIEDGPVTAENLSSETARKVPPIPTQIINEKGD--NSSENEVSAI 276

  Fly   737 PSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRS--NTVGASPSSKPTAEQLKSPMMDIFIK 799
            |:.....:|.      |:..|.....:.||.|.:...  .|..|.|  .|..|::||   :.|.|
Yeast   277 PTTSSPPLPP------RQNVATSTSPKLPPRGKQREQPPKTKNAVP--PPLEEEMKS---EKFRK 330

  Fly   800 VGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTE---FLSPMRKPAKRGKRDAAELRELWRT 861
                 ...||.:.|:....|    |.||....|...|   ..|..||.:....::..|.||..:.
Yeast   331 -----NFEETKRNSYHHVPL----TGSKTAQLESTAEINLIASRYRKTSHHLNKEGEETRESLQE 386

  Fly   862 AIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDP 926
            .  |:.:   ..|..:.|:.....||::.:..:..|:...|...   |.|::...:|...|  :|
Yeast   387 G--QSFL---KSTFTSFLENLSEYNEVENVNEEDREMFKIDWSF---WTQVVNDYATVASN--EP 441

  Fly   927 KVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLG 991
            :.|...:..|:|...||.:|..:|...|.....:           |..||.....|:..|..||.
Yeast   442 ENLEAHVTNGIPPQIRGIIWQLMANSKSREMEDI-----------YETLLDTECLHEATIRRDLR 495

  Fly   992 RTFPNHQFY-KDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCD-EANSFQLLKHL 1054
            ||    :|. :|.:.    ||:.::|.||:.||::||.||:|||...||::|: ||.||.||..|
Yeast   496 RT----KFVAEDKME----SLYKVIKVYSVYDPDVGYTQGMGFIAAPLLINCENEAESFGLLVGL 552

  Fly  1055 MFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLG 1119
            |....:|..:||.|....|.|||..||:::|.|.||..|.:..:|.|:||..|.||.|:.:|||.
Yeast   553 MKNYGLRELFLPGMPGLMLMLYQFDRLLEEHSPSLYNRLIREGISSTMYATQWFLTFFAYKFPLE 617

  Fly  1120 FVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKT------VVPKMEHTCMEQ 1178
            ||.|:||::|:|..:|:.|||:.|: :..::.|.|..|:|::|:||.      ::...:...:.|
Yeast   618 FVLRIFDIVFVEGIEVLLKFAVNLM-LKNEETLVKLRFDELLDFLKDELFNYYLMGNQDDASVVQ 681

  Fly  1179 IMKL------------VFSMDIG--------------KQLAEYKVEYNVLQEEITTTNHHLEMLN 1217
             |.|            .||.::.              ..|..|:.||..:.|:......|.|.|.
Yeast   682 -MGLSNGNSFKGNDDGTFSYNVDLFVHDAMTGVYITPLTLRRYRGEYVEIHEKEQKKEDHYESLR 745

  Fly  1218 REKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQ------------------ITTLQSQVQSLELT 1264
            .:..|.|...|:|:...|.:.:...:.:::..|                  ||.::||::. |:.
Yeast   746 IQNHQLQREAQKLEHDYSILNKENISAANELIQNRLNMEMLLDEKNDLINTITDIKSQIEE-EIR 809

  Fly  1265 IQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDR--QRRKPIFTERKIGKSVSVNSHLGFPLK 1327
            .|.|         .|||..||....|     :||:|  .|...:..|         |..|  ..:
Yeast   810 KQNL---------PNPDASLPKADLR-----EDLERTISRNNEVMRE---------NGQL--EER 849

  Fly  1328 VLEELTERDELGSPQKQKKEKTPFFEQ 1354
            :.|...|.|||.:..|::.......|:
Yeast   850 ITELQAEIDELININKEQVSTASLLER 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	52/249 (21%)
		DUF3350	831..880	CDD:463365	10/51 (20%)
		TBC	933..1152	CDD:214540	81/220 (37%)
		COG4372	<1190..>1353	CDD:443500	40/182 (22%)
GYP5	NP_015075.1	COG5210	154..737	CDD:227535	179/702 (25%)
		YhaN	720..>860	CDD:443752	37/165 (22%)