Protein Alignment plx and MSB3

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_014106.1
• Gene: MSB3 / 855423
• SGDID: S000005237
• Length: 633
• Species: Saccharomyces cerevisiae
• Alignment Length: 655
• Identity: 130/655 - (19%)
• Similarity: 234/655 - (35%)
• Gaps: 191/655 - (29%)

  Fly   690 ESRQQRHVHDTAENRSEFLNQY--LGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDI 752
            ::.|||.   :.:||:...:.|  |||:  |.....|:.| |.:.:....|..|.|:.:.:.|..
Yeast     2 QNDQQRF---SLQNRTVLAHPYKRLGGA--FTVKSPSVPN-FHDKMHSDHSSSDSALVNGSFRAN 60

  Fly   753 REGSAEP--LGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWR 815
            ...|.||  ||..||.|...:.|                   ::|::   |:   |.|:.:
Yeast    61 DHRSVEPSCLGQASPSEHDGNLS-------------------VIDLY---GD---EVESQR---- 96

  Fly   816 QAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQ 880
                      ::|.|.:         ......|..|..|:.......:.......|:|.|.|...
Yeast    97 ----------AEGEDDD---------DNNGDNGNEDLEEVHSDDLDLVPDDDNRQRVELEGAASA 142

  Fly   881 ARQNENELKRIKLD---------YEEIVPCDKQLIE----------RWEQIIERNSTQIGNKKDP 926
            ...|.|.:.....|         |......||..:|          :|:.::|::...:.:....
Yeast   143 TSANSNGINNTHFDRYGFKKQNNYISEAEYDKWWVEYSQYCVRRKHKWQLLLEKSGLPVTDDSPS 207

  Fly   927 KV------LGHAIRTGVPRSKRGDVWTFLAE-QHSMNTAPVDTKRFPNFNTPYHMLLKHL----- 979
            :.      |...:|.|:|...||:.|...|. |..:|          .....|..||:.:
Yeast   208 RFPSKSERLKRYVRKGIPAEWRGNAWWHFARGQEKLN----------KNKGVYSQLLRKMKQIKK 262

  Fly   980 ---TEHQ----HAIFIDLGRTFPNHQFYKDPLGLGQ-----LSLFNLLKAYSILDPELGYCQGLG 1032
               .|.|    ..|..||.||||::..::..|...:     .||..:|.|:|:.:|::||||.:.
Yeast   263 QNPNEKQVQDLDIIERDLNRTFPDNIHFQSSLHNKEGPPIIKSLRRVLVAFSLYNPKIGYCQSMN 327

  Fly  1033 FICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSR-----LVKDHLPDLYVW 1092
            |:.|:|||..||..:|.:|..:      .::|||.:....|:...:.:     .||:::|:::.:
Yeast   328 FLAGLLLLFLDEERAFWMLVII------TSRYLPGVHNINLEGVNIDQGVLMLCVKEYIPEVWSY 386

  Fly  1093 L---------DQNDVSP---------------------TLYAAPWILTVFSSQFPLGFVARVFDL 1127
            :         :....||                     ||..|.|.::.|....|:....|::|.
Yeast   387 IKPSIDHHQKNNKTFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETTLRIWDC 451

  Fly  1128 LFLESSDVIFKFAIALLSVHKQQLL-------------------------AKDNFEEIMDYLKTV 1167
            ||.|.|..:||.::|:|.:.:..|.                         .:|:..||...::|
Yeast   452 LFYEESHFLFKVSLAVLKLSEHDLSKIKPRNNSLNYSWGSNLNQRGGSMGQEDSDMEIFQVIQT- 515

  Fly  1168 VPKMEHTCMEQIMKLVFSMDIG-------------KQLAEYKVEYNVLQEEITTTNHHLEMLNRE 1219
            .||......|...|::|.....             |.:|..::::....|.:..:....::...:
Yeast   516 FPKTLLNPNEIFEKIIFKRRFNLNRLDQDEIDRCRKFVAAQRLKFKTYGELLGNSTSEADLPIND 580

  Fly  1220 KTQNQ 1224
            .|.|:
Yeast   581 NTDNK 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	7/48 (15%)
		TBC	933..1152	CDD:214540	66/271 (24%)
		COG4372	<1190..>1353	CDD:443500	5/35 (14%)
MSB3	NP_014106.1	COG5210	15..540	CDD:227535	120/592 (20%)