Protein Alignment plx and TBC1D3F

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_115634.3
• Gene: TBC1D3F / 84218
• HGNCID: 18257
• Length: 549
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 71/322 - (22%)
• Similarity: 132/322 - (40%)
• Gaps: 32/322 - (9%)

  Fly   851 DAAELRELWRTAIRQTIMLNRMETENAMLQA-------RQNENELKRIKLDYE-EIVPCDKQLIE 907
            |..|:...|....|:.|::...:...|.|..       |...|.:..:.:.:| |:.|...:..:
Human     2 DVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAK 66

  Fly   908 RWEQIIERNS---TQIGN----KKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRF 965
            :..:.|.|.|   ..:|:    |...|::..|.: |:|.:.||.:|:.|     :|...:..|
Human    67 QIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYK-GMPMNIRGPMWSVL-----LNIEEMKLK-- 123

  Fly   966 PNFNTPYHMLL----KHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELG 1026
               |...:.::    |..:||...|..|:..|...|.|::|..|..|..|.::|.||...:||:|
Human   124 ---NPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVG 185

  Fly  1027 YCQGLGFICGVLLLHCDEANSFQLLKHLMF--RRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDL 1089
            ||:.|..|..:.||:..|.::|..|..|:.  |.:::..:.|:....|....|...:|....|..
Human   186 YCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKT 250

  Fly  1090 YVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQL 1151
            ....|:.|:.........::.:......||...|::|:..:|....:.........|.:::|
Human   251 MGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	6/28 (21%)
		TBC	933..1152	CDD:214540	52/225 (23%)
		COG4372	<1190..>1353	CDD:443500
TBC1D3F	NP_115634.3	TBC	99..312	CDD:214540	51/223 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..425
		PHA03381	<356..>468	CDD:177618