DRSC/TRiP Functional Genomics Resources

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Protein Alignment plx and TBC1D10A

DIOPT Version :10

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:NP_001191169.1 Gene:TBC1D10A / 83874 HGNCID:23609 Length:515 Species:Homo sapiens


Alignment Length:604 Identity:137/604 - (22%)
Similarity:221/604 - (36%) Gaps:191/604 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   868 MLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHA 932
            :|:|:| |..:...||.|::.    ||          ::..|::.:.:...:|..:         
Human    74 LLHRLE-EVPLEVLRQRESKW----LD----------MLNNWDKWMAKKHKKIRLR--------- 114

  Fly   933 IRTGVPRSKRGDVWTFLA------EQH-----SMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAI 986
            .:.|:|.|.||..|.:|:      :|:     .::.:|.|.|..                  ..|
Human   115 CQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWL------------------DVI 161

  Fly   987 FIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLL 1051
            ..||.|.||.|:.:....|.||..||.:||||::..||.||||....|..|||:|.....:|..|
Human   162 ERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCL 226

  Fly  1052 KHLMFRRNMRTKYLPDMKKFQLQLYQLS-----RLVKDHLPDLYVWLDQNDVSPTLYAAPWILTV 1111
            ..:.      .||||.....:|:..||.     .|::...|..:..|.:..:.|.||...|.:..
Human   227 VQIC------EKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCA 285

  Fly  1112 FSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVH----KQQLLAKDNFEEIMDYLKTVVPKME 1172
            ||...|...|.||:|:.|.|...:||:..:.||. |    .:::.|.....|.::.|:::.||  
Human   286 FSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLK-HALGSPEKVKACQGQYETIERLRSLSPK-- 347

  Fly  1173 HTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSI 1237
                  ||:..|       |.:..||..|.:.:|               :.:||.|        :
Human   348 ------IMQEAF-------LVQEVVELPVTERQI---------------EREHLIQ--------L 376

  Fly  1238 AQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVG--QLVEHNPDLELPNEVRRMLQQLDDLDR 1300
            .:.:.||.                ||..::..|..|  .:::..|.      .|..||       
Human   377 RRWQETRG----------------ELQCRSPPRLHGAKAILDAEPG------PRPALQ------- 412

  Fly  1301 QRRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLN 1365
                         .|.|:...|..||              |..:.|.|.|   :..|::|:.::.
Human   413 -------------PSPSIRLPLDAPL--------------PGSKAKPKPP---KQAQKEQRKQMK 447

  Fly  1366 GGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGT 1430
            |.||...        ||: ||:.:..|:|.....        |:||..     |.....|| ...
Human   448 GRGQLEK--------PPA-PNQAMVVAAAGDACP--------PQHVPP-----KDSAPKDS-APQ 489

  Fly  1431 PLSPPSTASNSSGGSIFSR 1449
            .|:|..:|.:.|..|:.|:
Human   490 DLAPQVSAHHRSQESLTSQ 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967
DUF3350 831..880 CDD:463365 4/11 (36%)
TBC 933..1152 CDD:214540 68/238 (29%)
COG4372 <1190..>1353 CDD:443500 27/164 (16%)
TBC1D10ANP_001191169.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
TBC 117..320 CDD:214540 67/227 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..515 36/172 (21%)
PRK10819 <403..>493 CDD:236768 31/155 (20%)
Binding to the PDZ domain of EBP50 512..515
Blue background indicates that the domain is not in the aligned region.

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