Protein Alignment plx and sgsm2

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_068069810.1
• Gene: sgsm2 / 799094
• ZFINID: ZDB-GENE-131119-52
• Length: 1057
• Species: Danio rerio
• Alignment Length: 1160
• Identity: 211/1160 - (18%)
• Similarity: 360/1160 - (31%)
• Gaps: 418/1160 - (36%)

  Fly   244 NLKMSEAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTH 308
            |..:||..|..|.........::...|..........|.|...|...|||:...:..     .|.
Zfish    80 NTTVSEICRKVQEQLQQQAEITRRTQSTGQESLRRQGSSTGRAPQPLSAQAIKHIWV-----RTA 139

  Fly   309 FFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGG------VGIEAKP 367
            .||       :|..| :....:|:|   .|.|:.:.|       |..|..|.      ||..|..
Zfish   140 LFE-------KVLDK-IVQYIVDNA---SKYYEREAL-------MHDSVFGPILAALLVGPCALE 186

  Fly   368 SSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQL-QLTGAEEGAAPRPLEDNKENKSPEKRP 431
            .:.||:.|           |...|.|    |..|||. ::.||..|          :..||.:||
Zfish   187 YTKLKTSD-----------HFWTDPS----ANELVQRHRIHGAHRG----------QEVSPGRRP 226

  Fly   432 LLRGQSQIELG-HKEHSDGS---QPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGPSQL 492
                    .|| .|..|.||   ...||:::....::..|                      |::
Zfish   227 --------ALGIRKRQSSGSMSEDKFAASAREYVESLHQN----------------------SRV 261

  Fly   493 HPNYAMDNI---PKQRDRSASQGCIPPYVEQNRTMVFL-------------VGRCDLR------- 534
            |..|..:|:   || :|....:|    |:..::|...|             :|.|||.
Zfish   262 HLLYGKNNVLVQPK-KDMEVLRG----YLSLHQTAETLTLKWTPNQLINGTLGDCDLEKSIYWDY 321

  Fly   535 -LISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIA 598
             |..|.|:.|           |:|                          |.....|...:..::
Zfish   322 ALTVPLRQIV-----------CIH--------------------------CHQRPDCGGTLVLVS 349

  Fly   599 Q-----------------AFDTCAEQKKKQDTQIFSCEHCPMLW--------YHKL--------C 630
            |                 ||.:|.|.......|:.     |.||        :.||        .
Zfish   350 QDGIQRPPLHFPPGGHLLAFLSCLETGLLPRGQLE-----PPLWSQRGKGKVFPKLRKRNSTARL 409

  Fly   631 TDVEGLSEKKTQALILRRI-----------------------ETLSDDEQE-----IVWAKFCGS 667
            .|.:|..|.:..|..:.||                       .:|.|||:|     .:.:..|..
Zfish   410 VDQDGDGEDQIAADYVFRIVYPGHRHDSTVTINYHHSTGSRAPSLDDDEEEEDRLHAMISMICSR 474

  Fly   668 EKTNSPVAEQNQFLMML----------LRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAK 722
            ..|:..|.:.:..||.:          .:..|.|           :.|..|:...|||...::..
Zfish   475 NLTDPNVMKDHGDLMEMQGFGGSPLSWQQGECTS-----------HMSSCLSCSTGGSNASVELP 528

  Fly   723 RSLTNSFDNL--------LKRKPSKDDI------------------AVPSHNLRDIREGSAEPLG 761
            .|.|...|.:        :||:......                  |:.:||:
Zfish   529 ASCTCMHDRIPLKMLCQNMKRQIVSRAFYGWLAYCRHLSTVRTHLSALVNHNI------------ 581

  Fly   762 TQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPS 826
              .||:               || .|.......|::.|.....|       ::::..|..:|...
Zfish   582 --VPPD---------------KP-CEASGGLSKDVWSKYQKDCK-------NYKELELLRLVYYG 621

  Fly   827 KGLDSEVPTEFLSPMRKPAKRG--KRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELK 889
             |::.|:..|....:....|.|  |::.|::.|. .||..|.:|   .|.:...:..:|.|.|::
Zfish   622 -GVEHEIRKEVWPFLLGHYKFGMDKKNMAQIDEK-ITARYQQVM---REWKACEVIVKQREKEMQ 681

  Fly   890 R---IKLDYEEIVPCDKQLIERWEQIIERNSTQIGNK---------------------------- 923
            .   .||.....:  |..::    ::|.|:|| |.|:
Zfish   682 SAIFAKLSSGSSI--DSHVL----RLIHRDST-ISNEVFMSVDEPDAGGQDTSCEDSTPTLTTVV 739

  Fly   924 --------KDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKR---------------- 964
                    :.|.|...:..:|:|.|:...|    |..||...:.:|..:
Zfish   740 TPAMLAPDERPLVEFDSPDSGLPSSRNYSV----ASGHSQIMSSIDDGQSMEEDTTPTGGLEEQG 800

  Fly   965 --------------------------FPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDP 1003
                                      .|:|::....||..:..:.|.|..|:.|...|: :|...
Zfish   801 GRGSLSEDKLCSQLDKLTTTSSSEGTAPSFSSYTIELLDTVALNLHRIDKDVQRCDRNY-YYFTS 864

  Fly  1004 LGLGQLSLFNLLKAYSILDPELGYCQGL-GFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPD 1067
            ..|.:|.  |::.:|.....|:||.||: ..:..::::..||..::.....||.|.:..   .|.
Zfish   865 SNLEKLR--NIMCSYVWEHLEIGYVQGMCDLLAPLMVILDDECLAYSCFTQLMRRMSQN---FPT 924

  Fly  1068 MKKFQLQLYQLSRLVKDHLPDLYVWLDQN-DVSPTLYAAPWILTVFSSQFPLGFVARVFDLLF-- 1129
            ..........:..|::....:|:..:.|| |.:...:...|.|..|..:.....|..|:::::
Zfish   925 GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWVA 989

  Fly  1130 --LESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKL 1182
              :.|...:...|:||:.|::..:|  ||..:..|.:|......|...::.|:::
Zfish   990 PRISSKHFVLFIALALVEVYRDIIL--DNNMDFTDIIKFFNEMAERHDVQHILRM 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	66/351 (19%)
		DUF3350	831..880	CDD:463365	12/50 (24%)
		TBC	933..1152	CDD:214540	48/266 (18%)
		COG4372	<1190..>1353	CDD:443500
sgsm2	XP_068069810.1	RUN	19..201	CDD:459241	33/154 (21%)
		PH_RUTBC	262..432	CDD:275431	39/216 (18%)
		TBC	<845..1014	CDD:214540	36/174 (21%)