Protein Alignment plx and GRTP1

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001273661.1
• Gene: GRTP1 / 79774
• HGNCID: 20310
• Length: 344
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 86/278 - (30%)
• Similarity: 132/278 - (47%)
• Gaps: 23/278 - (8%)

  Fly   908 RWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPY 972
            :|.:::     |.|.....:.:...:|.|||...|..||..|      :.|.....:.|.:   |
Human    45 KWSRLL-----QGGGVPRSRTVKRYVRKGVPLEHRARVWMVL------SGAQAQMDQNPGY---Y 95

  Fly   973 HMLL--KHLTEHQHAIFIDLGRTFP-NHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFI 1034
            |.||  :.....:.||..||.|||| |.:|.|......|.:|:|:|.||...:..:|||||:.||
Human    96 HQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFI 160

  Fly  1035 CGVLLLHC-DEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDV 1098
            .|.|:|.. :|..||.||..|: .|.:...|.|.|...:.....|..||:..||.:...:::..|
Human   161 AGYLILITNNEEESFWLLDALV-GRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGV 224

  Fly  1099 SPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDY 1163
            ..||..:.|.:.:|....|:..|.|::|.||.|.|.:||:.|:.|:..|::.:|...:..:|.|.
Human   225 LWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDK 289

  Fly  1164 LKTVVP---KME-HTCME 1177
            .|.:..   .|| ||.|:
Human   290 FKQITKGSFVMECHTFMQ 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365
		TBC	933..1152	CDD:214540	74/222 (33%)
		COG4372	<1190..>1353	CDD:443500
GRTP1	NP_001273661.1	TBC	65..278	CDD:214540	74/222 (33%)