Protein Alignment plx and EVI5

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_016857758.1
• Gene: EVI5 / 7813
• HGNCID: 3501
• Length: 930
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 170/731 - (23%)
• Similarity: 305/731 - (41%)
• Gaps: 161/731 - (22%)

  Fly   762 TQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPS 826
            |......||   |..|...::...||:|.|.:..:        |...:|..|   .:.:.|.:||
Human     3 TNKMTAAFR---NPSGKQVATDKVAEKLSSTLSWV--------KNTVSHTVS---QMASQVASPS 53

  Fly   827 KGLDSEVPTEFLS-PMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQ---------- 880
            ..|.:...:..|| |...|:...:....:|.           :|.::|.:|.:|:
Human    54 TSLHTTSSSTTLSTPALSPSSPSQLSPDDLE-----------LLAKLEEQNRLLETDSKSLRSVN 107

  Fly   881 -ARQN-----------ENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGH-- 931
             :|:|           .:.|..::   |:......:::..||.:.::...|: ...:..||.|
Human   108 GSRRNSGSSLVSSSSASSNLSHLE---EDSWILWGRIVNEWEDVRKKKEKQV-KPFECWVLYHHS 168

  Fly   932 -----------------AIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHL 979
                             .:..|:|...|..||..|....||   |:..:        |..|||..
Human   169 QLCRFQVHYLKRSHTEELVHKGIPHHFRAIVWQLLCSAQSM---PIKDQ--------YSELLKMT 222

  Fly   980 TEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDE 1044
            :..:..|..|:.||:|.|.|:|:...|||..|||::||||::|.|:|||||..||.|:||:...|
Human   223 SPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 287

  Fly  1045 ANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWIL 1109
            ..:|.:...||....:|..:.|.|.:..|.:||...::::|||:|:|.........::||:.|.|
Human   288 EEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFL 352

  Fly  1110 TVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHT 1174
            |:|.:.|||....|:||:...|..:::|:..:|||.:::.:|:..| .|.::.:.:.|:|.....
Human   353 TIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLD-MEGMLQHFQKVIPHQFDG 416

  Fly  1175 CMEQIMKLVFSMDIGKQLAEYKVEYN-----VLQEEITT--TNHHLEM--LNREKTQNQHLEQQL 1230
            ..:::::           |.|:|:||     .|::|.||  |....|.  :.|.:|:|:.|:|::
Human   417 VPDKLIQ-----------AAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRI 470

  Fly  1231 QFAQSSIAQL-------ETTRSSQ-------QAQITTLQSQVQ----SLELTIQTLGRYVGQLVE 1277
            :..:...|.|       :.||:.:       :.::.|::.|..    .||....|:.:...|...
Human   471 ETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASAKLEQAENTIRKLQHQQQW 535

  Fly  1278 H------NPDLELPNEVRRMLQQLDDLDRQ------RRKPIFTERKIGKSVSVNSHLGFPLKVLE 1330
            |      |.|..|..|...:..:|.:.:.|      :.|.:..|::.......|:        :.
Human   536 HKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDENN--------IA 592

  Fly  1331 ELTERDELGSPQKQKKEKTPFFEQLRQQ-------QQQHRLNGGGQSSNVGESGSPTPPSRPNRL 1388
            .|.|  ||.:.:.::.|.....::||||       .|:|      .:...|....|...:..|.|
Human   593 RLQE--ELIAVKLREAEAIMGLKELRQQVKDLEEHWQRH------LARTTGRWKDPPKKNAMNEL 649

  Fly  1389 LDNASARTVMQVKLDE 1404
            .|.     :|.::|.|
Human   650 QDE-----LMTIRLRE 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	8/49 (16%)
		TBC	933..1152	CDD:214540	75/218 (34%)
		COG4372	<1190..>1353	CDD:443500	41/201 (20%)
EVI5	XP_016857758.1	TBC	187..395	CDD:214540	75/218 (34%)
		Smc	<433..>752	CDD:440809	50/249 (20%)