DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and EVI5

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	XP_016857758.1	Gene:	EVI5 / 7813	HGNCID:	3501	Length:	930	Species:	Homo sapiens

Alignment Length:	731	Identity:	170/731 - (23%)
Similarity:	305/731 - (41%)	Gaps:	161/731 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 TQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPS 826
            |......||   |..|...::...||:|.|.:..:        |...:|..|   .:.:.|.:||
Human     3 TNKMTAAFR---NPSGKQVATDKVAEKLSSTLSWV--------KNTVSHTVS---QMASQVASPS 53

  Fly   827 KGLDSEVPTEFLS-PMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQ---------- 880
            ..|.:...:..|| |...|:...:....:|.           :|.::|.:|.:|:
Human    54 TSLHTTSSSTTLSTPALSPSSPSQLSPDDLE-----------LLAKLEEQNRLLETDSKSLRSVN 107

  Fly   881 -ARQN-----------ENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGH-- 931
             :|:|           .:.|..::   |:......:::..||.:.::...|: ...:..||.|
Human   108 GSRRNSGSSLVSSSSASSNLSHLE---EDSWILWGRIVNEWEDVRKKKEKQV-KPFECWVLYHHS 168

  Fly   932 -----------------AIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHL 979
                             .:..|:|...|..||..|....||   |:..:        |..|||..
Human   169 QLCRFQVHYLKRSHTEELVHKGIPHHFRAIVWQLLCSAQSM---PIKDQ--------YSELLKMT 222

  Fly   980 TEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDE 1044
            :..:..|..|:.||:|.|.|:|:...|||..|||::||||::|.|:|||||..||.|:||:...|
Human   223 SPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 287

  Fly  1045 ANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWIL 1109
            ..:|.:...||....:|..:.|.|.:..|.:||...::::|||:|:|.........::||:.|.|
Human   288 EEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFL 352

  Fly  1110 TVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHT 1174
            |:|.:.|||....|:||:...|..:::|:..:|||.:::.:|:..| .|.::.:.:.|:|.....
Human   353 TIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLD-MEGMLQHFQKVIPHQFDG 416

  Fly  1175 CMEQIMKLVFSMDIGKQLAEYKVEYN-----VLQEEITT--TNHHLEM--LNREKTQNQHLEQQL 1230
            ..:::::           |.|:|:||     .|::|.||  |....|.  :.|.:|:|:.|:|::
Human   417 VPDKLIQ-----------AAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRI 470

  Fly  1231 QFAQSSIAQL-------ETTRSSQ-------QAQITTLQSQVQ----SLELTIQTLGRYVGQLVE 1277
            :..:...|.|       :.||:.:       :.::.|::.|..    .||....|:.:...|...
Human   471 ETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASAKLEQAENTIRKLQHQQQW 535

  Fly  1278 H------NPDLELPNEVRRMLQQLDDLDRQ------RRKPIFTERKIGKSVSVNSHLGFPLKVLE 1330
            |      |.|..|..|...:..:|.:.:.|      :.|.:..|::.......|:        :.
Human   536 HKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDENN--------IA 592

  Fly  1331 ELTERDELGSPQKQKKEKTPFFEQLRQQ-------QQQHRLNGGGQSSNVGESGSPTPPSRPNRL 1388
            .|.|  ||.:.:.::.|.....::||||       .|:|      .:...|....|...:..|.|
Human   593 RLQE--ELIAVKLREAEAIMGLKELRQQVKDLEEHWQRH------LARTTGRWKDPPKKNAMNEL 649

  Fly  1389 LDNASARTVMQVKLDE 1404
            .|.     :|.::|.|
Human   650 QDE-----LMTIRLRE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	8/45 (18%)
		TBC	933..1152	CDD:214540	75/218 (34%)
		RILP-like	<1176..1267	CDD:304877	24/117 (21%)
EVI5	XP_016857758.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4436
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840